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Increased expression of atrial natriuretic peptide in the kidney of rats with bilateral ureteral obstruction. Background. Whether the postobstructive diuresis can be related to an altered regulation of local atrial natriuretic peptide (ANP) in the kidney was investigated. Methods. Three groups of rats had both of their ureters obstructed for 48 hours. The kidneys were taken without releasing the obstruction in one group [bilateral ureteral obstruction (BUO)]. The obstruction was released in the other two groups and the animals were kept for 4 and 24 hours thereafter to collect urinary data (BUR-4 and BUR-24, respectively). Plasma and urine ANP levels were measured by radioimmunoassay. The mRNA expression of ANP, natriuretic peptide receptor-A (NPR-A), and NPR-C was determined by reverse transcription-polymerase chain reaction. ANP receptors were also quantitated by in vitro autoradiography. The activity of guanylyl cyclase was determined by the amount of cGMP generated in response to ANP. Results. Urinary volume and sodium excretion increased in BUR-4, along with the ANP mRNA expression in the kidney and the urinary ANP excretion. The ANP excretion positively correlated with the urinary volume and sodium excretion. The mRNA expression of both NPR-A and NPR-C was decreased by BUO, the latter being far more prominently affected. The maximal binding capacity of radiolabeled ANP was decreased in the glomerulus and papilla in BUO. Not only the urinary parameters but also the mRNA expression of ANP, NPR-A, and NPR-C were comparable between BUR-24 and control rats. ANP-stimulated cGMP generation was reduced in the glomerulus and papilla in BUO animals, which was rapidly resumed following the release of the obstruction. Conclusions. Postobstructive diuresis may be due partially to an increased ANP activity in the kidney. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 69-year-old woman with polyuria and bilateral knee pain. The patient undergo abdominal computed tomography (CT) which reveals bilateral hydronephrosis. Magnetic resonance imaging shows diffuse irregular sclerotic changes involving the diaphysis and metaphysic. Immunohistochemistry discovered that biopsy samples were CD68(+), but S-100(-) and CD1a(-), which is a distinctive finding in Erdheim-Chester disease.

The article discusses a case of a 43-year-old man who was presented to a hospital with generalized skin pruriginous and papulonodular eruptions. It say that a skin biopsy was performed and found symptoms of hyperkeratosis, pseudo-epitheliomatous acanthosis, and vascular hyperplasia of the upper dermis that are characteristics of prurigo nodularis. It states that tapere 16 milligram (mg) dose of oral methylprednisolone, antibiotics, antihistamines, ad cyrotherapy was treated to the patient.