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Abstract Inflammation status are especially for tumor growth, and microRNAs (miRNAs) confirmed to participate in cancer occurrence and progression. However, the role of miR‐483‐5p and the relation with inflammation have not been elucidated in renal cell cancer (RCC). In this study, we intended to explore miR‐483‐5p expression and the relationship of inflammation status in clear cell renal cell cancer (ccRCC). Using microarray and qRT‐PCR (Quantitative Real‐time Polymerase Chain Reaction), we investigated the miR‐483‐5p expression in plasma and ccRCC cancer tissues. Then, we analyzed the correlation of miR‐483‐5p with clinicopathological parameters and inflammation status in ccRCC. Receiver operator characteristic (ROC) curves analysis was used to analyze the discrimination efficiency of miR‐483‐5p. in vitro experiments explored the biological role of miR‐483‐5p in renal cancer cells. miR‐483‐5p expression was upregulated in plasma of 5 patients with microarray and 12 patients with qRT‐PCR in ccRCC at day 7 postoperatively. In addition, low expression of miR‐483‐5p was found in 58 ccRCC cancer tissues when compared with non‐cancerous tissues. miR‐483‐5p could sufficiently discriminate ccRCC with the area under the curve (AUC) of 0.739 (P