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2. Three cases of hepatitis E infected with subgenotype 3e hepatitis E virus indigenous to Mie Prefecture, which reemerged for the first time in six years

Author

Naohiko Yoshizawa, Atsuya Shimizu, Tatsunori Nakano, Shima Hamaoka, Soichiro Kobayashi, Kazumoto Murata, Hiroaki Okamoto, Akira Hashimoto, Masaharu Takahashi, Naohito Urawa, Takamitsu Tanaka, Yuji Kojima, Hiroshi Okano, and Shigeo Nagashima

Subjects
Hepatology, Hepatitis E virus, medicine, Biology, Hepatitis E, medicine.disease, medicine.disease_cause, Virology, Indigenous
Published
2021

3. Characteristics of cases of hepatitis E in 2019 in Gunma prefecture: a small epidemic caused by the same subgenotype 3a strain

Author

Hiroki Tojima, Masaharu Takahashi, Hiroaki Okamoto, Hiroaki Nakajima, Toshio Uraoka, Ken Sato, Satoshi Takakusagi, Hitoshi Takagi, Shigeo Nagashima, Takashi Ueno, Daichi Takizawa, Satoru Kakizaki, Takayoshi Suga, Yuki Kanayama, Daisuke Uehara, Atsushi Naganuma, Takashi Kosone, Yuichi Yamazaki, and Takeshi Hatanaka

Subjects
Hepatology, Strain (chemistry), medicine, Biology, Hepatitis E, medicine.disease, Virology
Published
2020

4. A fatal case of exacerbated liver cirrhosis caused by acute hepatitis E virus infection: atypical dynamics of anti-hepatitis E virus antibody titers

Author

Hiroki Asakawa, Akira Nishimura, Hiroaki Okamoto, Hiroki Tanaka, Tomonori Saito, Katsumi Mukai, Tomomasa Tochio, Kenji Nose, Shimpei Matsusaki, Tomohiro Sase, Yoshiaki Isono, Masaharu Takahashi, Hiroaki Kumazawa, Hiroshi Okano, and Satomi Tsuruga

Subjects
Hepatitis E Virus Antibody, Titer, Cirrhosis, Hepatology, business.industry, Acute hepatitis E, Medicine, business, medicine.disease, Virology, Virus
Published
2020

5. A case of autochthonous hepatitis E infected with subgenotype 4a hepatitis E virus endemic in China without overseas travel

Author

Ryohei Sak-Aguchi, Miho Miyoshi, Kunihiro Higuchi, Shigehito Nakashima, Naoki Nakagawa, Yoshiyuki Takei, Satoshi Takaji, Masaharu Takahashi, Toshitaka Fukui, Hiroaki Okamoto, Shozo Watanabe, Tatsunori Nakano, and Shigeo Nagashima

Subjects
Hepatology, Hepatitis E virus, medicine, Biology, Hepatitis E, medicine.disease, medicine.disease_cause, China, Virology
Published
2020

6. Three pairs of six sporadic acute hepatitis E cases infected with three different genotype 3b hepatitis E virus strains occurred within the same economic bloc in the central region of Japan

Author

Hiroshi Okano, Shigeo Nagashima, Kazuaki Takahashi, Masahiro Arai, Jun Ichi Sugihara, Makoto Yamawaki, Yusuke Suzuki, Hiroaki Okamoto, Masaharu Takahashi, Eiichi Tomita, Yoichi Nishigaki, Makoto Kobayashi, Tatsunori Nakano, Koji Yamashita, and Shogo Shimizu

Subjects
Hepatology, Hepatitis E virus, Acute hepatitis E, Genotype, medicine, Biology, medicine.disease_cause, Central region, Virology
Published
2018

7. A case of advanced gastric cancer with severe thrombocytopenia after administration of Nivolumab, following acute hepatitis E with decreased platelet count

Author

Koji Yamashita, Masaharu Takahashi, Jun Ichi Sugihara, Shogo Shimizu, Shigeo Nagashima, Tatsunori Nakano, and Hiroaki Okamoto

Subjects
medicine.medical_specialty, Hepatology, Acute hepatitis E, business.industry, Internal medicine, Decreased platelet count, medicine, Nivolumab, Advanced gastric cancer, business, Gastroenterology, Severe thrombocytopenia
Published
2018

8. An autochthonous case of acute hepatitis E in Mie, Japan who was infected with a rare hepatitis E virus strain of subgenotype 3f

Author

Hiroaki Okamoto, Masaharu Takahashi, Koujiro Takase, Hiroshi Okano, Katsuya Shiraki, Yumi Oya, and Tatsunori Nakano

Subjects
0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Hepatology, Hepatitis E virus, Strain (chemistry), Acute hepatitis E, medicine, 030211 gastroenterology & hepatology, Biology, medicine.disease_cause, Virology
Published
2017

9. Two cases of sporadic acute hepatitis E in Mie, Japan who were infected with subgenotype 1a hepatitis E virus

Author

Tadashi Maekawa, Satoko Uraki, Hideaki Tanaka, Makoto Yamawaki, Makoto Kobayashi, Tatsunori Nakano, Yoshiyuki Takei, Katsuya Shiraki, Masaharu Takahashi, Hiroshi Okano, Jun Ninomiya, and Hiroaki Okamoto

Subjects
0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, Hepatology, 030106 microbiology, 030212 general & internal medicine, Biology
Published
2016

10. Metachronous occurrence of two cases of acute hepatitis E after eating raw pig liver and heart at the same restaurant at Gifu city in Japan

Author

Yusuke Suzuki, Kazuaki Takahashi, Masahiro Arai, Yoichi Nishigaki, Hiroaki Okamoto, Eiichi Tomita, Masaharu Takahashi, Tatsunori Nakano, Hideki Hayashi, Junichi Sugihara, Tomohiro Kato, and Shogo Shimizu

Subjects
medicine.medical_specialty, Hepatology, Acute hepatitis E, business.industry, Internal medicine, medicine, business, Pig liver, Gastroenterology
Published
2015

11. A case of acute hepatitis E in Mie prefecture infected with genotype 4 hepatitis E virus strain endemic in Aichi and Shizuoka prefectures (Aichi/Shizuoka strain), without a history of eating wild animal meat

Author

Satoshi Ishida, Tatsunori Nakano, Michihiro Izumi, Kunihiro Higuchi, Ryuichi Aikawa, Shino Fujimoto, Nagako Kitagawa, Yoshiyuki Takei, Naoki Nakagawa, Yukihiko Adachi, Hiroaki Okamoto, and Masaharu Takahashi

Subjects
Hepatology, Hepatitis E virus, Acute hepatitis E, Strain (biology), Genotype, medicine, Biology, medicine.disease_cause, Virology
Published
2014

12. Transmission of genotype A (A2) hepatitis B virus from patients who developed acute hepatitis B to their sexual partners, via interspousal or homosexual infection

Author

Hiroaki Okamoto, Tatsuya Aikawa, Hiroaki Sugiyama, Kazuto Ikezawa, Takashi Mamiya, Atsuko Soeda, Fumio Tsuda, Masaharu Takahashi, Shigeo Nagashima, and Chisato Ueno

Subjects
Hepatitis B virus, Hepatology, Transmission (medicine), Genotype, medicine, Biology, Acute hepatitis B, medicine.disease_cause, Virology
Published
2013

13. Two cases with imported hepatitis A who were presumed to have contracted the disease while visiting Indonesia based on molecular analysis of hepatitis A virus strains

Author

Yoichirou Natori, Masahiro Ishikane, Kuniaki Hirata, Keiichi Furukawa, Ryoji Tatsumi, Soro Takeda, Manri Kawakami, Kazuhisa Yokota, Toshio Sekioka, Takahiro Takemoto, Hiroaki Okamoto, Takashi Ikeya, Masaharu Takahashi, Toshiki Tanaka, and Tatsuro Kobata

Subjects
Hepatology, business.industry, Immunology, medicine, Hepatitis A, Disease, medicine.disease, business, Virology, Hepatitis a virus, Molecular analysis
Published
2012

14. Epidemiological survey of hepatitis E virus infection in Kushiro and Nemuro cities in eastern Hokkaido: relationship between regional difference of HEV prevalence and distinct food cultures

Author

Hitoshi Mizuo, Toshio Tanabe, Yasuyuki Yazaki, Masaharu Takahashi, and Hiroaki Okamoto

Subjects
medicine.medical_specialty, Hepatology, Immunology, Epidemiology, medicine, Biology, Virology, Hepatitis E virus infection
Abstract

我が国においてE型肝炎患者数が最も多い北海道におけるE型肝炎ウイルス（HEV）感染の地域差の有無を検討するため，釧路市721例および根室市687例の血清検体についてIgG型HEV抗体を測定し，既報の札幌市および北見市の住民での測定結果と比較した．抗体陽性率は釧路市で5.4％，根室市で2.0％であり，両市とも男性で有意に高率であった（釧路市，男性8.5％ vs. 女性3.0％，P=0.0010；根室市，4.0％ vs. 0.5％，P=0.0012）．40歳以上の年代で各市の抗体陽性率を比較すると，釧路市と北見市，札幌市との間で有意差は認められなかったが（それぞれ7.9％，12.1％，6.4％），根室市では2.1％に過ぎず，北見市，札幌市および釧路市よりも有意に低率であった．道内4都市での感染率の地域差は地域産業および食文化の相違を背景にしたブタ肉・内臓消費量の違いに由来すると推測された．

Published
2011

15. A case of acute hepatitis C, most likely by interspousal sexual transmission after 40 years of marriage

Author

Masaharu Takahashi, Hiroaki Okamoto, Maki Kojima, Tatsuya Aikawa, Kuniko Miyamoto, and Chisato Ueno

Subjects
Gynecology, medicine.medical_specialty, Sexual transmission, Hepatology, business.industry, medicine, Acute hepatitis C, business, Virology
Abstract

67歳の男性が結婚40年後にC型急性肝炎を発症した．その妻（68歳）がC型慢性肝炎患者であり，C型肝炎ウイルス（HCV）RNAが高力価陽性（>5,000 KIU/ml）であった．両者のHCV遺伝子型はともに1b型で，NS5B領域の1,087塩基長の配列において99.7%の一致率を示した．それに対し，これまでに報告されているHCV/1b株との一致率は最高でも96.7%に過ぎなかった．分子系統樹解析によっても，夫婦の持つHCV株は一つのクラスター（bootstrap値：100%）を形成し，同一株である可能性が強く示唆された．詳細な病歴聴取を行ったが，性交渉（月1, 2回）以外の感染経路はいずれも否定された．高齢夫婦間の感染には加齢に伴う生体側因子が関与していると考えられるが，高齢化社会を迎え，HCV感染者頻度の高い高齢者層でかかるHCV感染が起こる可能性を念頭に置く必要があると考え報告する．

Published
2008

16. A case of imported hepatitis E: Identification of location of HEV infection by the molecular epidemiological approach

Author

Maki Kojima, Kuniko Miyamoto, Hiroaki Okamoto, Fumio Tsuda, Tatsuya Aikawa, Chisato Ueno, and Masaharu Takahashi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Epidemiology, Medicine, business, Hepatitis E, medicine.disease, Virology
Abstract

患者は30歳男性．2006年1月から4カ月間中国の雲南省とチベット自治区，ネパール，およびタイの順に旅行し，タイに移動後間もなく褐色尿と黄疸に気づき帰国した．患者血清からはE型肝炎ウイルス（HEV）RNAが検出され，遺伝子型は1型と判定された．取材旅行であったことより日々の飲食を全て記録しており，生ものや生水の摂取は旅行中一切無かったが，ネパールでの水かけ祭「ホーリー」に参加し，泥水を誤飲したことが感染契機になったとみられた．さらに，1型の既知全クローンとの比較から，感染したHEV株は2005年12月にネパールで分離されたHEV株と100%の一致率を示し，ネパールで感染したことがHEVクローンの遺伝子解析から裏付けられた．ネパールでは2006年春においても同種株の流行が続いていたことが推測された．

Published
2007

17. Four cases of hepatitis E after eating wild boar meats in Aichi, Japan

Author

K. Morita, Masaharu Takahashi, Yoshihiro Ishiguro, Masahiko Yamada, Hidemi Goto, Hiroaki Okamoto, Hidezumi Tatematsu, Yuko Shimizu, Makoto Ishihara, and Yoshiaki Katano

Subjects
Veterinary medicine, Hepatology, Wild boar, biology, biology.animal, medicine, Hepatitis E, medicine.disease
Abstract

愛知県内で捕獲された野生イノシシの肉・内臓を摂食し，約1∼2カ月後にE型肝炎を発症した症例を2005年と2006年に2例ずつ合計4例経験した．いずれも中高年男性であり，3例に飲酒歴を認め1例に薬剤服用歴を認めた．4例いずれも著明な肝逸脱酵素の上昇を示し，2例で劇症化が懸念されステロイドパルス治療を施行，うち1例は血漿交換療法を施行した．分離されたHEV株の遺伝子型はいずれも4型であり，互いに98.8∼99.8%の塩基配列一致率を示すと同時に，最近愛知県内の野生イノシシから分離されたHEV株とも99.1∼100%の一致率を示した．一方，これまでに北海道を中心に他県で分離されている4型HEV株との一致率は85.4%∼89.3%に過ぎなかった．以上の結果より，野生イノシシを感染源とする土着HEVの感染が愛知県内で広がりつつあることが危惧され，感染予防の観点から，早急の感染実態の調査・把握が重要である．

Published
2006

20. A first case of pregnant woman who contracted infection of indigenous genotype 3 hepatitis E virus in Japan

Author

Kuniko Miyamoto, Tatsuya Aikawa, Fumio Tsuda, Kunihiko Yamagata, Hiroaki Okamoto, and Masaharu Takahashi

Subjects
Hepatitis, Hepatology, business.industry, viruses, virus diseases, Hepatitis A, medicine.disease, Hepatitis E, medicine.disease_cause, Virology, digestive system diseases, Hepatitis E virus, Genotype, medicine, Liver function, Viral hepatitis, business, Acute hepatitis
Abstract

A 35-year-old woman who was 14 weeks pregnant visited a gynecology hospital to undergo a surgical abortion. Although she was not jaundiced, and had no signs of hepatitis, liver function was abnormal (ALT, 100 IU/L; AST, 96 IU/L). The serum obtained was negative for markers of hepatitis A, B, and C viruses. However, based on the positive results of non-routine IgM/IgA anti-HEV and HEV RNA assays, the patient was occasionally diagnosed with sporadic acute hepatitis E. The HEV isolate recovered from the patient was phylogenetically close to known genotype 3 HEV strains circulating in Japan, with the highest identity of 93.2%. We believe that testing for hepatitis E should be routine in Japan, in cases of suspected viral hepatitis.

Published
2009

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