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Objective: To determine the effectiveness of lateral insoles in patients of Knee Osteoarthritis for improving activities of daily living among patients with Knee Osteoarthritis. Methodology: This a single blinded, Randomized controlled clinical trial conducted on 40 subjects at Madinah Teaching Hospital, physiotherapy clinics from 25 Feb 2016 to 26 August 2016 after approval from Institutional Review Board. By using simple convenient method subjects were recruited and randomized using coin toss method into group A and B. The study was completed in 07 months. Subjects diagnosed with Osteoarthritis (OA) on the basis of clinical and radiological finding of medial compartment knee OA grade II and III were included. Subjects were included as per inclusion criteria of study and then divided in two groups with 20 subjects in each. Activity of daily living was assessed at baseline, 2nd, 4th and 6th week. Using SPSS V.20 repeated measures ANOVA was used for analysis of outcome of interest. Results: The results showed that there was significant improvement in activities including bathing, standing, and sitting, getting in and out of car and ascending chairs. The experimental group treated with lateral Insoles, showed greater improvement comparing pre and post intervention as compared to control group (P