1. Epigenetic regulation of adipocyte differentiation and adipogenesis
- Author
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Yonggong Zhai, Lei Xiao, Jia-li Gao, Hong-xing Li, and Cheng Wang
- Subjects
Epigenetic regulation of neurogenesis ,Transcription, Genetic ,Epigenetic code ,Cellular differentiation ,Retinoblastoma Protein ,General Biochemistry, Genetics and Molecular Biology ,Epigenesis, Genetic ,Adipocytes ,CCAAT-Enhancer-Binding Protein-alpha ,Animals ,Humans ,Nucleosome ,Epigenetics ,General Pharmacology, Toxicology and Pharmaceutics ,Genetics ,Adipogenesis ,General Veterinary ,biology ,Cell Differentiation ,General Medicine ,Cell biology ,PPAR gamma ,Histone ,DNA methylation ,biology.protein ,Sterol Regulatory Element Binding Protein 1 ,Biotechnology - Abstract
It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.
- Published
- 2010
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