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Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the risk factors for in-stent restenosis (ISR) within one year after drug eluting stent (DES) intervention and the predictive value of secretory phospholipase A2 (sPLA2) and high sensitivity c-reactive protein (hs-CRP) in patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods From January 2014 to January 2016, the 120 patients who received DES in the Affiliated Hospital of Yan'an University were divided into ISR group and non-ISR group according to the results of coronary angiography. We evaluated the general clinical data and serum sPLA2 and hs-CRP levels before and after PCI. Then we used multivariate logistic regression analysis to find the independence risk factors for ISR within one year. Results The occlusion lesions (31.43% vs. 17.65%) and stent reconstruction (31.43% vs. 16.47%) in ISR group were significantly higher than those in non-ISR group (P<0.05). The rate of post-ballooning of stents was higher (11.43% vs. 35.29%, P<0.05) in non-ISR group than that in ISR group. The hs-CRP and sPLA2 concentrations in ISR group were significantly higher than those in non-ISR group (P<0.05) before and after PCI and they were obviously increased after PCI in both groups (P<0.05). We also found that ISR was correlated with hs-CRP, sPLA2, occlusion lesions, and post-ballooning of stents (P<0.05). Conclusion The occlusion lesions, post-ballooning of stent, hs-CRP and sPLA2 may be the independence risk factors for ISR within one year. Serum sPLA2 and hs-CRP have the predictive value for ISR after DES implantation in patients with coronary heart disease. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To detect the content changes of endogenous hydrogen sulfide (H2S) in the cerebral tissues after diffuse axonal injury (DAI) and observe the role of exogenous H2S in DAI so as to clarify the role of H2S as a new gas signaling molecule involved in the process of DAI and provide rationale supports for the prevention and treatment of neurological dysfunction after DAI. Methods The DAI model was established by a coronal rotation device and exogenous H2S was administered for intervention. Time points of 6h, 24h and 7d after DAI were chosen for observation. Methylene blue spectrophotometric method was used for detecting H2S content change in the brain tissues after DAI, flow cytometry for measuring the apoptosis of hippocampal CA3 neurons, and Western blot for determining the change of β-amyloid precursor protein (β-APP) expression in the cortex, hippocampus and brain stem. Results Compared with that in the control group, endogenous H2S content in the cortex, hippocampus and brainstem significantly increased in DAI groups, with DAI+H2S intervention groups having significantly higher H2S content than DAI model groups. The apoptosis of hippocampal CA3 neurons showed an increased early apoptosis percentage in the DAI model groups and more apoptotic neuron cells were observed in the longer time post-injury in DAI model groups. Furthermore, DAI (7d) + H2S group had a significantly higher early apoptosis percentage than DAI (7d) group. More importantly, Western blot showed that β-APP in the cortex, hippocampus and brain stem in DAI model groups was expressed higher than in the control group, with DAI+H2S intervention groups having a significantly higher β-APP expression than DAI model groups. Conclusion The increase of neuronal apoptosis and β-APP expression may be related to the increase of endogenous H2S after DAI. It suggests that H2S may be involved in the secondary neuronal injury of DAI as a new neurotransmitter. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of low molecular weight heparin (LMWH) and N-acetylcysteine (NAC) intervention on airway remodeling of chronic obstructive pulmonary disease (COPD) rats. Methods A total of 40 SPF-SD rats aged 6-8 weeks were equally divided into healthy control group (group C), COPD model (induced through cigarette smoke inhalation and intratracheal lipopolysaccharide infusion) group (group M), LMWH (subcutaneous injection of LMWH) intervention group (group L), NAC intervention (intragastric infusion of NAC) group (group N), and LMWH+NAC intervention group (group LN). We observed the pathological changes under light microscope, measured the bronchial wall depth by image analysis system, and checked airway submucosal collagen deposition using sirius red stain under the polarized microscope. Results ① COPD rat models had similar pathological changes to human COPD. ② The depth of bronchial wall increased in groups M, L, N and LN compared with group C (P<0.01). It decreased in groups L and LN as compared with group M, and the decrease was most significant in group LN (P<0.01). But there was no significant decrease of airway wall depth in group N (P>0.05). ③ There was deposition of type I collagen in all the groups, the decrease of collagen was more significant in group LN than in groups L and N. Conclusion ① COPD rat model can be easily constructed by smoke inhalation and intratracheal lipopolysaccharide (LPS) infusion in shorter duration; ② LMWH and NAC intervention independently or in-combination (in particular) can reduce the depth of bronchial wall and collagen deposition of COPD, thus decreasing airway remodeling in COPD. [ABSTRACT FROM AUTHOR]