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Your search keyword '"Wiertz, Emmanuel"' showing total 10 results
Start Over Author "Wiertz, Emmanuel" Journal journal of virology
10 results on '"Wiertz, Emmanuel"'

1. A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Author

Luteijn, Rutger D., primary, van Diemen, Ferdy, additional, Blomen, Vincent A., additional, Boer, Ingrid G. J., additional, Manikam Sadasivam, Saravanan, additional, van Kuppevelt, Toin H., additional, Drexler, Ingo, additional, Brummelkamp, Thijn R., additional, Lebbink, Robert Jan, additional, and Wiertz, Emmanuel J., additional

Published
2019
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5. The Capacity of UL49.5 Proteins To Inhibit TAP Is Widely Distributed among Members of the Genus Varicellovirus

Author

Verweij, Marieke C., primary, Lipińska, Andrea D., additional, Koppers-Lalic, Danijela, additional, van Leeuwen, Wouter F., additional, Cohen, Jeffrey I., additional, Kinchington, Paul R., additional, Messaoudi, Ilhem, additional, Bieńkowska-Szewczyk, Krystyna, additional, Ressing, Maaike E., additional, Rijsewijk, Frans A. M., additional, and Wiertz, Emmanuel J. H. J., additional

Published
2011
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9. Epstein-Barr Virus gp42 Is Posttranslationally Modified To Produce Soluble gp42 That Mediates HLA Class II Immune Evasion

Author

Ressing, Maaike E., primary, van Leeuwen, Daphne, additional, Verreck, Frank A. W., additional, Keating, Sinéad, additional, Gomez, Raquel, additional, Franken, Kees L. M. C., additional, Ottenhoff, Tom H. M., additional, Spriggs, Melanie, additional, Schumacher, Ton N., additional, Hutt-Fletcher, Lindsey M., additional, Rowe, Martin, additional, and Wiertz, Emmanuel J. H. J., additional

Published
2005
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10. The DNase of Gammaherpesviruses Impairs Recognition by Virus-Specific CD8+ T Cells through an Additional Host Shutoff Function.

Author

Jianmin Zuo, Thomas, Wendy, Van Leeuwen, Daphne, Middeldorp, Jaap M., Wiertz, Emmanuel J. H. J., Ressing, Maaike E., and Rowe, Martin

Subjects
*DEOXYRIBONUCLEASES, *HERPESVIRUSES, *T cells, *EPSTEIN-Barr virus, *KAPOSI'S sarcoma
Abstract

The DNase/alkaline exonuclease (AE) genes are well conserved in all herpesvirus families, but recent studies have shown that the AE proteins of gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) exhibit an additional function which shuts down host protein synthesis. One correlate of this additional shutoff function is that levels of cell surface HLA molecules are downregulated, raising the possibility that shutoff/AE genes of gammaherpesviruses might contribute to viral immune evasion. In this study, we show that both BGLF5 (EBV) and SOX (KSHV) shutoff/AE proteins do indeed impair the ability of virus-specific CD8+ T-cell clones to recognize endogenous antigen via HLA class I. Random mutagenesis of the BGLF5 gene enabled us to genetically separate the shutoff and AE functions and to demonstrate that the shutoff function was the critical factor determining whether BGLF5 mutants can impair T-cell recognition. These data provide further evidence that EBV has multiple mechanisms to modulate HLA class I-restricted T-cell responses, thus enabling the virus to replicate and persist in the immune-competent host. [ABSTRACT FROM AUTHOR]

Published
2008
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