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Your search keyword '"Geisbert, Thomas W."' showing total 18 results
Start Over Author "Geisbert, Thomas W." Journal journal of virology
18 results on '"Geisbert, Thomas W."'

2. Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization

Author

Wang, Yimeng, primary, Howell, Katie A., additional, Brannan, Jennifer, additional, Agans, Krystle N., additional, Turner, Hannah L., additional, Wirchnianski, Ariel S., additional, Kailasan, Shweta, additional, Fusco, Marnie, additional, Galkin, Andrey, additional, Chiang, Chi-I, additional, Zhao, Xuelian, additional, Saphire, Erica Ollmann, additional, Chandran, Kartik, additional, Ward, Andrew B., additional, Dye, John M., additional, Aman, M. Javad, additional, Geisbert, Thomas W., additional, and Li, Yuxing, additional

Published
2021
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5. Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38

Author

Mishra, Akaash K., primary, Moyer, Crystal L., additional, Abelson, Dafna M., additional, Deer, Daniel J., additional, El Omari, Kamel, additional, Duman, Ramona, additional, Lobel, Leslie, additional, Lutwama, Julius J., additional, Dye, John M., additional, Wagner, Armin, additional, Chandran, Kartik, additional, Cross, Robert W., additional, Geisbert, Thomas W., additional, Zeitlin, Larry, additional, Bornholdt, Zachary A., additional, and McLellan, Jason S., additional

Published
2020
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6. Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge

Author

Matassov, Demetrius, primary, Mire, Chad E., additional, Latham, Theresa, additional, Geisbert, Joan B., additional, Xu, Rong, additional, Ota-Setlik, Ayuko, additional, Agans, Krystle N., additional, Kobs, Dean J., additional, Wendling, Morgan Q. S., additional, Burnaugh, Amanda, additional, Rudge, Thomas L., additional, Sabourin, Carol L., additional, Egan, Michael A., additional, Clarke, David K., additional, Geisbert, Thomas W., additional, and Eldridge, John H., additional

Published
2018
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9. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

Author

Pattabhi, Sowmya, primary, Wilkins, Courtney R., additional, Dong, Ran, additional, Knoll, Megan L., additional, Posakony, Jeffrey, additional, Kaiser, Shari, additional, Mire, Chad E., additional, Wang, Myra L., additional, Ireton, Renee C., additional, Geisbert, Thomas W., additional, Bedard, Kristin M., additional, Iadonato, Shawn P., additional, Loo, Yueh-Ming, additional, and Gale, Michael, additional

Published
2016
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11. Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

Author

Geisbert, Thomas W., primary, Bailey, Michael, additional, Hensley, Lisa, additional, Asiedu, Clement, additional, Geisbert, Joan, additional, Stanley, Daphne, additional, Honko, Anna, additional, Johnson, Joshua, additional, Mulangu, Sabue, additional, Pau, Maria Grazia, additional, Custers, Jerome, additional, Vellinga, Jort, additional, Hendriks, Jenny, additional, Jahrling, Peter, additional, Roederer, Mario, additional, Goudsmit, Jaap, additional, Koup, Richard, additional, and Sullivan, Nancy J., additional

Published
2011
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12. Vector Choice Determines Immunogenicity and Potency of Genetic Vaccines against Angola Marburg Virus in Nonhuman Primates

Author

Geisbert, Thomas W., primary, Bailey, Michael, additional, Geisbert, Joan B., additional, Asiedu, Clement, additional, Roederer, Mario, additional, Grazia-Pau, Maria, additional, Custers, Jerome, additional, Jahrling, Peter, additional, Goudsmit, Jaap, additional, Koup, Richard, additional, and Sullivan, Nancy J., additional

Published
2010
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13. A Novel Model of Lethal Hendra Virus Infection in African Green Monkeys and the Effectiveness of Ribavirin Treatment

Author

Rockx, Barry, primary, Bossart, Katharine N., additional, Feldmann, Friederike, additional, Geisbert, Joan B., additional, Hickey, Andrew C., additional, Brining, Douglas, additional, Callison, Julie, additional, Safronetz, David, additional, Marzi, Andrea, additional, Kercher, Lisa, additional, Long, Dan, additional, Broder, Christopher C., additional, Feldmann, Heinz, additional, and Geisbert, Thomas W., additional

Published
2010
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18. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway.

Author

Pattabhi S, Wilkins CR, Dong R, Knoll ML, Posakony J, Kaiser S, Mire CE, Wang ML, Ireton RC, Geisbert TW, Bedard KM, Iadonato SP, Loo YM, and Gale M Jr

Subjects
Animals, Antiviral Agents isolation & purification, Cell Line, Gene Expression Profiling, Humans, Immunologic Factors isolation & purification, Viral Load, Virus Cultivation, Antiviral Agents pharmacology, Immunity, Innate drug effects, Immunologic Factors pharmacology, RNA Viruses immunology, RNA Viruses physiology, Virus Replication drug effects
Abstract

Unlabelled: The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 plays a critical role in antiviral immunity to drive the expression of innate immune response genes, including those encoding antiviral factors, type 1 interferon, and immune modulatory cytokines, that act in concert to restrict virus replication. Thus, small molecule agonists that can promote IRF3 activation and induce innate immune gene expression could serve as antivirals to induce tissue-wide innate immunity for effective control of virus infection. We identified small molecule compounds that activate IRF3 to differentially induce discrete subsets of antiviral genes. We tested a lead compound and derivatives for the ability to suppress infections caused by a broad range of RNA viruses. Compound administration significantly decreased the viral RNA load in cultured cells that were infected with viruses of the family Flaviviridae, including West Nile virus, dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus), and Paramyxoviridae (respiratory syncytial virus, Nipah virus) to suppress infectious virus production. Knockdown studies mapped this response to the RIG-I-like receptor pathway. This work identifies a novel class of host-directed immune modulatory molecules that activate IRF3 to promote host antiviral responses to broadly suppress infections caused by RNA viruses of distinct genera., Importance: Incidences of emerging and reemerging RNA viruses highlight a desperate need for broad-spectrum antiviral agents that can effectively control infections caused by viruses of distinct genera. We identified small molecule compounds that can selectively activate IRF3 for the purpose of identifying drug-like molecules that can be developed for the treatment of viral infections. Here, we report the discovery of a hydroxyquinoline family of small molecules that can activate IRF3 to promote cellular antiviral responses. These molecules can prophylactically or therapeutically control infection in cell culture by pathogenic RNA viruses, including West Nile virus, dengue virus, hepatitis C virus, influenza A virus, respiratory syncytial virus, Nipah virus, Lassa virus, and Ebola virus. Our study thus identifies a class of small molecules with a novel mechanism to enhance host immune responses for antiviral activity against a variety of RNA viruses that pose a significant health care burden and/or that are known to cause infections with high case fatality rates., (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Published
2015
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