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Your search keyword '"Egan, Karine"' showing total 3 results
Start Over Author "Egan, Karine" Journal journal of virology
3 results on '"Egan, Karine"'

1. Signaling through the Prostaglandin I 2 Receptor IP Protects against Respiratory Syncytial Virus-Induced Illness

Author

Hashimoto, Koichi, primary, Graham, Barney S., additional, Geraci, Mark W., additional, FitzGerald, Garret A., additional, Egan, Karine, additional, Zhou, Weisong, additional, Goleniewska, Kasia, additional, O'Neal, Jamye F., additional, Morrow, Jason D., additional, Durbin, Russell K., additional, Wright, Peter F., additional, Collins, Robert D., additional, Suzutani, Tatsuo, additional, and Peebles, R. Stokes, additional

Published
2004
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2. Signaling through the Prostaglandin I2 Receptor IP Protects against Respiratory Syncytial Virus-Induced Illness.

Author

Hashimoto, Koichi, Graham, Barney S., Geraci, Mark W., FitzGerald, Garret A., Egan, Karine, Zhou, Weisong, Goleniewska, Kasia, O'Neal, Jamye F., Morrow, Jason D., Durbin, Russell K., Wright, Peter F., Collins, Robert D., Suzutani, Tatsuo, and Peebles Jr., R. Stokes

Subjects
*PROSTAGLANDINS, *RESPIRATORY syncytial virus, *PROSTANOIDS, *PARAMYXOVIRUSES, *INFLAMMATORY mediators, *VIROLOGY, *MICROBIOLOGY
Abstract

The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I2 (PGI2). Mice that overpress PGI2 synthase selectively in bronchial epithelium are protected against RSV-induced weight loss and have decreased peak viral replication and gamma interferon levels in the lung compared to nontransgenic littermates. In contrast, mice deficient in the PGI2 receptor IP have exacerbated RSV-induced weight loss with delayed viral clearance and increased levels of gamma interferon in the lung compared to wild-type mice. These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI2 is a potential therapeutic target in the treatment of RSV. [ABSTRACT FROM AUTHOR]

Published
2004
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3. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness.

Author

Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K, Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright PF, Collins RD, Suzutani T, and Peebles RS Jr

Subjects
6-Ketoprostaglandin F1 alpha urine, Animals, Antibodies, Viral blood, Cytochrome P-450 Enzyme System genetics, Cytochrome P-450 Enzyme System metabolism, Disease Models, Animal, Female, Gene Deletion, Interferon-alpha biosynthesis, Interferon-beta biosynthesis, Interferon-gamma analysis, Intramolecular Oxidoreductases genetics, Intramolecular Oxidoreductases metabolism, Lung chemistry, Lung pathology, Lung virology, Male, Mice, Mice, Transgenic, Pulmonary Edema pathology, Pulmonary Edema prevention & control, Pulmonary Surfactant-Associated Protein A biosynthesis, Pulmonary Surfactant-Associated Protein B biosynthesis, Receptors, Epoprostenol genetics, Receptors, Epoprostenol immunology, Respiratory Mucosa, Respiratory Syncytial Virus Infections immunology, Respiratory Syncytial Virus Infections metabolism, Respiratory Syncytial Virus Infections pathology, Respiratory Syncytial Viruses growth & development, Respiratory Syncytial Viruses immunology, Weight Loss, 6-Ketoprostaglandin F1 alpha analogs & derivatives, Epoprostenol metabolism, Receptors, Epoprostenol metabolism, Respiratory Syncytial Virus Infections physiopathology, Respiratory Syncytial Viruses pathogenicity, Signal Transduction
Abstract

The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I(2) (PGI(2)). Mice that overexpress PGI(2) synthase selectively in bronchial epithelium are protected against RSV-induced weight loss and have decreased peak viral replication and gamma interferon levels in the lung compared to nontransgenic littermates. In contrast, mice deficient in the PGI(2) receptor IP have exacerbated RSV-induced weight loss with delayed viral clearance and increased levels of gamma interferon in the lung compared to wild-type mice. These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatment of RSV.

Published
2004
Full Text
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