Search

Your search keyword '"Tsuda, F."' showing total 4 results
Start Over Author "Tsuda, F." Journal journal of viral hepatitis
4 results on '"Tsuda, F."'

4. Interferon-alpha 2a for chronic hepatitis B with e antigen or antibody:comparable antiviral effects on wild-type virus and precore mutant.

Author

Aikawa T, Kanai K, Kako M, Kawasaki T, Hino K, Iwabuchi S, Tsubouchi H, Takehira Y, Tsuda F, and Okamoto H

Subjects
Adult, Base Sequence, DNA, Viral biosynthesis, DNA, Viral chemistry, Female, Hepatitis B Surface Antigens biosynthesis, Hepatitis B e Antigens biosynthesis, Hepatitis B virus genetics, Humans, Interferon alpha-2, Male, Middle Aged, Molecular Sequence Data, Mutation, Polymerase Chain Reaction, Recombinant Proteins, Hepatitis B drug therapy, Interferon-alpha therapeutic use
Abstract

Recombinant interferon-alpha 2a (IFN-alpha 2a) in a total dose of 702 MU was given to 31 patients: nine with wild-type hepatitis B virus (HBV) and hepatitis B e antigen (HBeAg) (A); four with HBeAg and a mixed infection with wild-type HB and precore mutants (B); 11 with antibody to HBeAg (HBeAb) and a mixed infection (C); and seven with HBeAb and precore mutants alone (D). HBV DNA was not cleared in any patient in groups A and B. By contrast, in patients with HBeAb, HBV DNA was ultimately lost in four patients in group C, as well as in 10 patients in group D. Thus, patients with HBeAb and infected with precore mutants alone (D) lost serum HBV DNA more often than those with HBeAg and wild-type HBV (A). Patients with low pretreatment levels of HBV DNA cleared virus more frequently, and the response of precore mutant to IFN was comparable with that of wild-type HBV in patients who had a mixed infection. Based on these results, precore mutants do respond to IFN, and therefore, IFN is indicated in patients with HBeAb, especially those with low serum HBV DNA levels.

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results