1. Pharmacokinetics of single dose oral Terbinafine in common shelducks (Tadorna tadorna)
- Author
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Carlos Barros-García, Mónica Valls, Carlos Rojo-Solís, Teresa Álvaro, Andrés Montesinos, Daniel García-Párraga, María Ardiaca-García, and Teresa Encinas
- Subjects
0301 basic medicine ,Antifungal Agents ,040301 veterinary sciences ,Cmax ,Administration, Oral ,Pharmacology ,High-performance liquid chromatography ,0403 veterinary science ,03 medical and health sciences ,Pharmacokinetics ,Oral administration ,Medicine ,Animals ,Adverse effect ,Terbinafine ,Chromatography, High Pressure Liquid ,General Veterinary ,business.industry ,04 agricultural and veterinary sciences ,Clinical Practice ,Fungal disease ,030104 developmental biology ,Area Under Curve ,business ,medicine.drug ,Half-Life - Abstract
Fungal disease is a major cause of morbidity and mortality in avian species; thus, antifungals are the treatment of choice. Despite widely used in clinical practice, terbinafine pharmacokinetic studies are scarce in literature and only cover some avian families, with marked differences between them. This study evaluates the pharmacokinetic behaviour of terbinafine after a single oral administration of 60 mg/kg in 7 healthy adult common shelducks (Tadorna tadorna) by measuring plasma concentrations through high-performance liquid chromatography (HPLC) at times 0, 30 min, 1, 2, 4, 6, 8, 10, 12, 24, 36 and 48 hr postadministration. Noncompartmental analyses of the data showed a Cmax (geometric mean) of 5.43 µg/ml, tmax (median) 1.0 hr and AUC0-∞ 29.70 mg h/L. Elimination half-life was 6.33 hr and MRT 6.61 hr. Plasma concentrations remained above previously described MIC for terbinafine in some fungal species for at least 6 to 8 hr. A single oral administration of 60 mg/kg terbinafine did not produce adverse effects and could be a good treatment choice for fungal diseases in anatids.
- Published
- 2020