1. Noradrenaline Content and Release in the Mesenteric Artery of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) and a New Strain of SHRSP (M-SHRSP)
- Author
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Satoru Sunano, Keiichi Shimamura, Tomoko Shimada, Kozo Okamoto, and Kazuo Yamamoto
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Adrenergic ,Strain (injury) ,Rats, Inbred WKY ,Rats, Mutant Strains ,Norepinephrine (medication) ,Norepinephrine ,Disease susceptibility ,Rats, Inbred SHR ,Internal medicine ,medicine ,Animals ,Norepinephrine metabolism ,Wistar Kyoto Rats ,Stroke ,business.industry ,Sodium ,Rats, Inbred Strains ,medicine.disease ,Mesenteric Arteries ,Rats ,Cerebrovascular Disorders ,medicine.anatomical_structure ,Endocrinology ,Anesthesia ,Hypertension ,Potassium ,Disease Susceptibility ,Cardiology and Cardiovascular Medicine ,business ,Artery ,medicine.drug - Abstract
Adrenergic innervation in the main trunk of the mesenteric artery was studied in stroke-prone spontaneously hypertensive rats (SHRSP) as well as in a new strain of SHRSP (M-SHRSP) and was compared with that of normotensive Wistar Kyoto rats (WKY). Noradrenaline (NA) content and high K-induced NA release in the artery of 6-week-old SHRSP and M-SHRSP were greater than those in the artery of WKY. These results suggest that a higher adrenergic innervation of the artery might be involved in the development of hypertension in SHRSP and M-SHRSP.
- Published
- 1987
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