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Your search keyword '"picotamide"' showing total 4 results
Start Over Descriptor "picotamide" Journal journal of urology
4 results on '"picotamide"'

2. MP68-08 INHIBITION OF NEUROGENIC, CHOLINERGIC, AND ADRENERGIC CONTRACTION OF HUMAN BLADDER SMOOTH MUSCLE BY THE THROMBOXANE RECEPTOR ANTAGONIST, PICOTAMIDE

Author

Frank Strittmatter, Christian G. Stief, Beata Rutz, Christian Gratzke, Martin Hennenberg, Yiming Wang, and Anna Ciotkowska

Subjects
medicine.medical_specialty, Contraction (grammar), business.industry, Urology, Human bladder, Adrenergic, Thromboxane receptor antagonist, Endocrinology, Smooth muscle, Internal medicine, medicine, Picotamide, Cholinergic, business, medicine.drug
Published
2016

3. 1595 INHIBITION OF EFS-, PHENYLEPHRINE-, AND THROMBOXANE-INDUCED CONTRACTION BY THE RECEPTOR ANTAGONIST, PICOTAMIDE, IN HUMAN PROSTATE SMOOTH MUSCLE

Author

Christian G. Stief, Claudius Füllhase, Martin Hennenberg, Beata Rutz, Christian Gratzke, Marijan Miljak, Yasemin Hocaoglu, and Frank Strittmatter

Subjects
Contraction (grammar), medicine.drug_class, Thromboxane, business.industry, Urology, Pharmacology, Receptor antagonist, Human prostate, Smooth muscle, medicine, Picotamide, business, Phenylephrine, medicine.drug
Published
2013

4. 1596 THE CAMP EFFECTOR EPAC ACTIVATES ELK1 TRANSCRIPTION FACTOR IN HUMAN PROSTATE SMOOTH MUSCLE, AND IS A MINOR REGULATOR OF α1-ADRENERGIC CONTRACTION

Author

Beata Rutz, Alexander Roosen, Christian G. Stief, Christian Gratzke, Frank Strittmatter, Henning Schmetkamp, Martin Hennenberg, and Sebastian Walther

Subjects
biology, business.industry, medicine.drug_class, Urology, Calponin, Antagonist, Adrenergic, Receptor antagonist, medicine.anatomical_structure, Stroma, Prostate, In vivo, Cancer research, biology.protein, Medicine, Picotamide, business, medicine.drug
Abstract

lial markers, pan-cytokeratin and prostate-specific antigen (PSA), and with TXS. Immunoreactivity for TXS was observed in the stroma and the epithel. TXS immunoreactivity colocalized with calponin, and pancytokeratin. CONCLUSIONS: The receptor antagonist picotamide inhibits 1-adrenergic, TXA2-mediated, and EFS-induced contractions in the human prostate. To the best of our knowledge, this is the first antagonist showing simultaneous interventions into different contraction systems of the prostate. In vivo studies are mandatory to examine urodynamic effects of picotamide, and to assess its efficacy for the treatment of LUTS.

Published
2013

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