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Start Over Author "Mehnert, Ulrich Journal journal of urology
122 results on '"Mehnert, Ulrich'

1. Neurogenic Lower Urinary Tract Dysfunction in the First Year After Spinal Cord Injury: A Descriptive Study of Urodynamic Findings

Author

Kozomara, Marko, primary, Birkhäuser, Veronika, additional, Anderson, Collene E., additional, Bywater, Mirjam, additional, Gross, Oliver, additional, Kiss, Stephan, additional, Knüpfer, Stephanie C., additional, Koschorke, Miriam, additional, Leitner, Lorenz, additional, Mehnert, Ulrich, additional, Sadri, Helen, additional, Sammer, Ulla, additional, Stächele, Lara, additional, Tornic, Jure, additional, Brinkhof, Martin W. G., additional, Liechti, Martina D., additional, and Kessler, Thomas M., additional

Published
2023
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2. Detrusor Acontractility after Acute Spinal Cord Injury—Myth or Reality?

Author

Jure Tornic, Thomas M. Kessler, Mirjam Bywater, and Ulrich Mehnert

Subjects
Adult, Male, medicine.medical_specialty, Ataxia, Urology, Urinary system, Urinary Bladder, 030232 urology & nephrology, urologic and male genital diseases, Vesicoureteral reflux, Dyssynergia, 03 medical and health sciences, 0302 clinical medicine, Urinary Bladder, Underactive, medicine, Humans, Prospective Studies, Urinary Bladder, Neurogenic, Prospective cohort study, Spinal cord injury, Spinal Cord Injuries, Aged, Urinary bladder, Electromyography, Urinary Bladder, Overactive, business.industry, Middle Aged, medicine.disease, Spinal cord, female genital diseases and pregnancy complications, Urodynamics, medicine.anatomical_structure, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Muscle Contraction
Abstract

We assessed urodynamic parameters within the first 40 days after spinal cord injury to investigate whether the detrusor is acontractile during the acute phase of spinal cord injury.We performed a prospective cohort study in 54 patients with neurogenic lower urinary tract dysfunction due to acute spinal cord injury who underwent urodynamic investigation within the first 40 days after injury at a single university spinal cord injury center.Urodynamic investigation revealed an acontractile detrusor in only 20 of the 54 patients (37%) but unfavorable urodynamic parameters in 34 (63%). We found detrusor overactivity in 32 patients, detrusor-sphincter dyssynergia in 25, maximum storage detrusor pressure greater than 40 cm HIn contrast to the common notion of an acontractile detrusor during acute spinal cord injury, almost two-thirds of our patients showed unfavorable urodynamic parameters within the first 40 days after spinal cord injury. Considering that early treatment of neurogenic lower urinary tract dysfunction in patients with acute spinal cord injury might improve the long-term urological outcome, urodynamic investigation should be performed timely to optimize patient tailored therapy.

Published
2018

3. MP53-16 ADAPTED BACTERIOPHAGES FOR TREATING URINARY TRACT INFECTIONS

Author

Archil Chkhotua, Wilbert Sybesma, Thomas M. Kessler, Aleksandre Ujmajuridze, Lorenz Leitner, Nina Chanishvili, Marina Goderdzishvili, and Ulrich Mehnert

Subjects
medicine.medical_specialty, business.industry, Urology, Urinary system, medicine, Intensive care medicine, business
Abstract

INTRODUCTION AND OBJECTIVES:Urinary tract infections (UTIs) are among the most widespread microbial diseases and their economic impact on the society is substantial. The continuing increase of anti...

Published
2019

5. PD36-07 PREDICTION OF AUTONOMIC DYSREFLEXIA DURING URODYNAMICS

Author

Andrei V. Krassioukov, Matthias Walter, Thomas M. Kessler, Armin Curt, Martin Schubert, Jacquelyn J. Cragg, Marc P. Schneider, Lorenz Leitner, Stephanie C. Knüpfer, and Ulrich Mehnert

Subjects
medicine.medical_specialty, Physical medicine and rehabilitation, business.industry, Urology, Medicine, Autonomic dysreflexia, business, medicine.disease
Published
2018

10. PD36-07 PREDICTION OF AUTONOMIC DYSREFLEXIA DURING URODYNAMICS

Author

Walter, Matthias, primary, Knüpfer, Stephanie C., additional, Cragg, Jacquelyn J., additional, Leitner, Lorenz, additional, Schneider, Marc P., additional, Mehnert, Ulrich, additional, Krassioukov, Andrei V., additional, Schubert, Martin, additional, Curt, Armin, additional, and Kessler, Thomas M., additional

Published
2018
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12. PD06-11 REPRODUCIBILITY OF SUPRASPINAL RESPONSES TO AUTOMATED, REPETITIVE BLADDER FILLING - AN FMRI STUDY

Author

Lars Michels, Matthias Walter, Lorenz Leitner, Ulrich Mehnert, Thomas M. Kessler, Patrick Freund, Martina D. Liechti, and Spyros Kollias

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Urology, Magnetic resonance imaging, Urinary incontinence, Surgery, medicine.anatomical_structure, nervous system, Gyrus, Neuroimaging, Posterior cingulate, medicine, medicine.symptom, Functional magnetic resonance imaging, Nuclear medicine, business, Insula, Anterior cingulate cortex
Abstract

INTRODUCTION AND OBJECTIVES: Recent functional magnetic resonance imaging (fMRI) studies revealed supraspinal networks in response to bladder filling involved in perception and processing of bladder distension. However, reproducibility of blood-oxygenation-level dependent (BOLD) signal changes during bladder filling has not been proven yet. Therefore, our aim was to investigate BOLD signal changes in response to bladder filling to provide evidence for repeatability using a standardized filling paradigm, i.e. a magnetic resonance (MR)compatible and MR-synchronized infusion-drainage system. METHODS: 20 right-handed healthy subjects, 10 women and 10 men, mean age 39 years (range 22-54) with no history of urinary urgency and/or urinary incontinence were included. Visit 1: After catheterization and bladder pre-filling with body warm saline until persistent desire to void, we performed in a 3T MR scanner automated, repetitive bladder filling of 100mL body warm saline over 15s, i.e. block design study. Visit 2: Within 8 weeks from visit 1, a second MR scan was performed in the same manner. Using SPM8, BOLD signal changes during bladder filling were compared to rest, i.e. pre-filled condition. For within-group whole-brain (WB) analysis, a voxel-threshold was set at p

Published
2016

15. MP17-15 BACTERIURIA IN PATIENTS UNDERGOING INTRADETRUSOR ONABOTULINUMTOXINA INJECTIONS FOR REFRACTORY NEUROGENIC DETRUSOR OVERACTIVITY: DO WE NEED ANTIBIOTIC PROPHYLAXIS?

Author

Thomas M. Kessler, Marc P. Schneider, Burkhardt Seifert, Lorenz Leitner, Ulla Sammer, Stephanie C. Knüpfer, Matthias Walter, and Ulrich Mehnert

Subjects
medicine.medical_specialty, Refractory, business.industry, Urology, Internal medicine, Medicine, In patient, Bacteriuria, Antibiotic prophylaxis, business, medicine.disease
Published
2016

22. PD1-10 SUPRASPINAL CONTROL OF LOWER URINARY TRACT FUNCTION IN PATIENTS WITH SPINAL CORD INJURY: AN FMRI STUDY

Author

Lars Michels, Lorenz Leitner, Matthias Walter, Thomas M. Kessler, Ulrich Mehnert, Martina D. Liechti, Patrick Freund, and Spyros Kollias

Subjects
business.industry, Urology, Urinary system, Middle temporal gyrus, Parietal lobe, Urinary incontinence, Medial frontal gyrus, medicine.disease, medicine.anatomical_structure, Anesthesia, Posterior cingulate, medicine, Autonomic dysreflexia, medicine.symptom, business, Spinal cord injury
Abstract

INTRODUCTION AND OBJECTIVES: The control of the lower urinary tract (LUT) is a complex, multilevel process involving both the peripheral and central nervous system. Most patients with spinal cord injury (SCI) suffer from neurogenic LUT dysfunction and LUT symptoms severely impair the patients’ health-related quality of life. Although there are several concepts regarding neuronal control and perception in the normal and pathological LUT condition, the exact mechanisms involved remain to be elucidated. METHODS: In this functional magnetic resonance imaging (fMRI) study, we prospectively assessed 20 patients (mean age 43 years old, range 25e75) with cervical and thoracic SCI (12 with complete and 8 with incomplete lesion) suffering from neurogenic detrusor overactivity. All subjects underwent data acquisition in a 3 Tesla scanner. The scan paradigm (SP) comprised 3 different bladder stimulations: (1) repetitive bladder filling of 100mL body warm saline starting with an empty bladder, (2) repetitive infusion and withdrawal (100mL) of body warm saline starting with a pre-filled bladder and (3) repetitive bladder filling of 100mL cold saline. Date was analysed using SPM8. Second-level random effects group analysis (at a voxel-threshold of P

Published
2015

23. MP12-06 SUPRASPINAL ACTIVITY TO AUTOMATED, REPETITIVE BLADDER FILLING - AN FMRI STUDY

Author

Matthias Walter, Spyros Kollias, Thomas M. Kessler, Lorenz Leitner, Ulrich Mehnert, and Lars Michels

Subjects
medicine.medical_specialty, Urinary urgency, business.industry, Brain activity and meditation, Urology, medicine.medical_treatment, Urinary system, Urinary incontinence, Neuroimaging, Statistical significance, Internal medicine, medicine, Cardiology, medicine.symptom, business, Saline, Insula
Abstract

INTRODUCTION AND OBJECTIVES: Recent fMRI studies revealed supraspinal networks in response to bladder filling involved in perception and processing of bladder distension. However significance of supraspinal network activity and network localizations varied largely due to the different filling protocols. Therefore, our aim was to standardize filling paradigms using a MR-synchronized pump system for accurate timing and filling volume. METHODS: 31 right-handed healthy subjects, 16 women and 15 men, mean age 34 years (range 19e54) with no history of urinary urgency and/or urinary incontinence were included, were prospectively investigated using a 3 Tesla Phillips scanner. After catheterization, bladder was pre-filled until a persistent desire to void was perceived by each subject. The scan paradigm comprised automated, repetitive bladder filling of 100 mL body warm saline over 15sec by using a MRcompatible pump system, i.e. block design study. Neuroimaging data was analyzed with SPM8. Blood-oxygenation-level dependent signal analysis during bladder filling was compared to rest, i.e. pre-filled bladder. Second-level random effects group analysis was corrected for gender, age and total intracranial volume and was performed to account for between-subject variability, i.e. within-group results at P1⁄40.05 familywise error rate (FWE). RESULTS: 3 subjects, 2 women and 1 man, were excluded from further analysis due to excessive head motions. Within-group results from the remaining 28 subjects revealed activation in the following brain regions: bilateral insula, left inferior parietal lobe (BA40) and right frontal inferior operculum (BA44). CONCLUSIONS: Automated, repetitive bladder filling of body warm saline elicited robust brain activity on a high significance level in specific areas known to be involved in supraspinal lower urinary tract control.

Published
2015

33. 123 CURRENT PERCEPTION THRESHOLDS OF THE LOWER URINARY TRACT IN HEALTHY MEN

Author

Stephanie Knuepfer, Ulrich Mehnert, Thomas M. Kessler, Flavia Gregorini, Martina D. Liechti, and Jens Woellner

Subjects
medicine.medical_specialty, business.industry, Urology, Perception, media_common.quotation_subject, Urinary system, Internal medicine, Medicine, Current (fluid), business, media_common
Published
2013

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