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Megaprepuce is a congenital penile malformation that includes phimosis and severe ballooning of the internal prepuce. We combined the main technical details of 2 previously reported surgical techniques to simplify the surgical approach. We report the key points of this revisited surgical correction for megaprepuce and the long-term results.Penile reconstruction was performed between March 2004 and March 2009 in 26 children 2 to 19 months old (median age 6) with congenital megaprepuce. Surgical repair consisted of limited preputial resection of the phimotic ring, wide dissection of the outer prepuce to the base of the penis, fixation of the proximal outer prepuce to Buck's fascia to create a new penoscrotal junction, and unfurling and wide tailoring of the inner prepuce in the ventral midline to resurface the whole elongated penile shaft. A bladder catheter was left in place for 5 or 6 days. Only patients with at least 6 months of followup were included in analysis.All patients underwent surgery on an outpatient basis. Operative time was between 50 and 85 minutes. Median followup was 17.6 months (range 6 to 59). Two patients had slight dehiscence of the ventral suture, which healed spontaneously without a scar. In 1 patient transient urethral meatal stenosis developed. The final cosmesis result was adequate in all patients.It is possible to correct megaprepuce and achieve an adequate genital aspect with a simple approach of resurfacing the penis with the unfurled, tailored inner prepuce.

bladder catheter through the dome. In the CMG measurements in a decerebrated condition, mice underwent cystostomy formation and supracollicular decerebration under isoflurane-anesthesia. After recovery from the anesthesia (waiting for at least 2 hours), CMG was carried out with saline-instillation at 10 ml/min. RESULTS: In the FV measurements, in females, mean voided volume and mean flow rate in TRPM2-KO mice were significantly greater than those in WT mice. In males, similar tendencies were observed, but there were no significant differences (n 1⁄4 10, in each group). In the conscious CMG measurements, in females, threshold pressure, micturition pressure, intercontraction interval and mean voided volume in TRPM2-KO mice were significantly greater than those in WT mice. In contrast, in male mice, only threshold pressure in TRPM2-KO mice was significantly higher than that in WT mice (Figure 1A, n 1⁄4 8 in each group). In the CMG measurements in the decerebrated condition, only threshold pressure in TRPM2-KO mice was significantly higher than that in WT mice in both sexes (Figure 1B, male TRPM2-KO n 1⁄4 7, other groups n 1⁄4 8). CONCLUSIONS: The present study suggests that TRPM2 channels may have a role in modulating bladder mechano-sensation in mice, and also that this contribution might be more remarkable in females.

This report contains case studies on three children with early end-stage renal failure due to renal malformation or nephrotic syndrome, but without bladder involvement. All patients became anuric in the second year of life, before having obtained bladder control. They underwent successful cadaveric renal transplantation, having been anuric for almost 2 to 4 years. When the bladder catheter was removed 5 days after transplantation, all three children asked for the urine potty without ever having been prompted. Three weeks after transplantation, all three children achieved complete bladder control during the day, and two of them also at night. These observations add further evidence to the notion that the development of bladder control is a consequence of maturation and not of training.