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Your search keyword '"Abdel-Karim A"' showing total 32 results
Start Over Author "Abdel-Karim A" Journal journal of urology
32 results on '"Abdel-Karim A"'

1. PD11-06 EVALUATION OF LAPAROENDOSCOPIC SINGLE SITE SURGERY VERSUS MINILAPAROSCOPY IN RADICAL NEPHRECTOMY: PROSPECTIVE RANDOMIZED COMPARATIVE STUDY

Author

Ahmed Abouelkhair, Wally Mahfouz, Ahmed Eid, and Aly Abdel Karim

Subjects
medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, medicine, Single site surgery, business, Nephrectomy, Surgery
Abstract

INTRODUCTION AND OBJECTIVE:We aimed to present the first prospective randomized comparison between laparoendoscopic single-site surgery (LESS) and minilaparoscopy (ML) radical nephrectomy for treat...

Published
2020

3. Urological Laparoendoscopic Single Site Surgery: Multi-Institutional Analysis of Risk Factors for Conversion and Postoperative Complications

Author

Bo Yang, Jeffrey A. Cadeddu, Jens-Uwe Stolzenburg, Alessandro Volpe, Lee Richstone, Riccardo Autorino, Georges-Pascal Haber, Abhay Rane, Fernando J. Kim, Sara L. Best, Rene Sotelo, Ithaar Derweesh, Sebastien Crouzet, Seung Wook Lee, Evangelos Liatsikos, Wassim M. Bazzi, Anibal Branco, Rachid Yakoubi, Deok Hyun Han, Wesley M. White, Luca Cindolo, Byong Chang Jeong, Phillip M. Pierorazio, Aly Abdel-Karim, Joo Yong Lee, Salah Elsalmy, Sun Ying-hao, Wilson R. Molina, Jihad H. Kaouk, Woong Kyu Han, Francesco Greco, Panagiotis Kallidonis, C. Giedelman, Soroush Rais-Bahrami, Robert J. Stein, Paolo Fornara, Koon Ho Rha, Carlo Terrone, Luigi Schips, Mohamad E. Allaf, Autorino, Riccardo, Kaouk, Jh, Yakoubi, R, Rha, Kh, Stein, Rj, White, Wm, Stolzenburg, Ju, Cindolo, L, Liatsikos, E, Rais Bahrami, S, Volpe, A, Han, Dh, Derweesh, Ih, Lee, Sw, Abdel Karim, Am, Branco, A, Greco, F, Allaf, M, Sotelo, R, Kallidonis, P, Jeong, Bc, Best, S, Bazzi, W, Pierorazio, P, Elsalmy, S, Rane, A, Han, Wk, Yang, B, Schips, L, Molina, Wr, Fornara, P, Terrone, C, Giedelman, C, Lee, Jy, Crouzet, S, Haber, Gp, Richstone, L, Yinghao, S, Kim, Fj, and Cadeddu, Ja

Subjects
Adult, Male, medicine.medical_specialty, Urology, Urinary system, Logistic regression, Cohort Studies, Postoperative Complications, Risk Factors, Humans, Medicine, Robotic surgery, Laparoscopy, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Incidence, Incidence (epidemiology), Middle Aged, Surgery, Endoscopy, Logistic Models, Cohort, Single site surgery, Urologic Surgical Procedures, Female, business
Abstract

We analyzed the incidence of and risk factors for complications and conversions in a large contemporary series of patients treated with urological laparoendoscopic single site surgery.The study cohort consisted of consecutive patients treated with laparoendoscopic single site surgery between August 2007 and December 2010 at a total of 21 institutions. A logistic regression model was used to analyze the risks of conversion, and of any grade and only high grade postoperative complications.Included in analysis were 1,163 cases. Intraoperatively complications occurred in 3.3% of cases. The overall conversion rate was 19.6% with 14.6%, 4% and 1.1% of procedures converted to reduced port laparoscopy, conventional laparoscopic/robotic surgery and open surgery, respectively. On multivariable analysis the factors significantly associated with the risk of conversion were oncological surgical indication (p=0.02), pelvic surgery (p0.001), robotic approach (p0.001), high difficulty score (p=0.004), extended operative time (p=0.03) and an intraoperative complication (p=0.001). A total of 120 postoperative complications occurred in 109 patients (9.4%) with major complications in only 2.4% of the entire cohort. Reconstructive procedure (p=0.03), high difficulty score (p=0.002) and extended operative time (p=0.02) predicted high grade complications.Urological laparoendoscopic single site surgery can be done with a low complication rate, resembling that in laparoscopic series. The conversion rate suggests that early adopters of the technique have adhered to the principles of careful patient selection and safety. Besides facilitating future comparisons across institutions, this analysis can be useful to counsel patients on the current risks of urological laparoendoscopic single site surgery.

Published
2012

7. Modulation of Insulin-Like Growth Factor-I System of The Bladder Using a Somatostatin Analogue in Chronic Spinalized Rats

Author

Hung Huynh, M. Abdel-Gawad, Mostafa M. Elhilali, and A.M. Abdel-Karim

Subjects
Detrusor muscle, medicine.medical_specialty, business.industry, Urology, Octreotide, Smooth muscle hyperplasia, Spinal cord, medicine.disease, Muscle hypertrophy, Endocrinology, Somatostatin, medicine.anatomical_structure, Internal medicine, medicine, Smooth muscle hypertrophy, business, Spinal cord injury, medicine.drug
Abstract

Purpose: We have previously reported the possible role of the insulin-like growth factor-I (IGF-I) system of mitogens in the development of detrusor smooth muscle hyperplasia and hypertrophy after spinal cord injury. We evaluated the in vivo effects of the anti-growth factor somatostatin analogue octreotide on the IGF-I system as well as subsequent changes in bladder smooth muscle hypertrophy and function after spinal cord injury in rats.Materials and Methods: Included in this study were 90 adult female Sprague-Dawley rats weighing 200 to 250 gm. Of the rats 18 served as sham operated controls, while the remaining 72 underwent were spinal cord transection at the level of the T10 vertebra. The spinalized animals were randomly divided into 4 equal groups of 18, of which 1 group served as paraplegic controls. The other 3 groups received octreotide (60 μg. daily for 4 weeks) delivered via a subcutaneously implanted osmotic pump immediately, 2 and 4 weeks after spinal cord injury. At the end of the exp...

Published
2002

11. 830 OUTCOMES OF LAPAROENDOSCOPIC SINGLE SITE PYELOPLASTY: A MULTI-INSTITUTIONAL CUMULATIVE ANALYSIS

Author

Soroush Rais-Bahrami, Akihiro Kawauchi, Michael A. Liss, Riccardo Autorino, Arvin K. George, Jihad H. Kaouk, Salah Elsalmy, Derweesh Ithaar, Emad Rizkala, Jeffrey A. Cadeddu, Robert Stein, Vulcan Tugcu, Aly Abdel-Karim, Georges-Pascal Haber, Lee Richstone, and Aditya Bagrodia

Subjects
Pyeloplasty, medicine.medical_specialty, Single site, business.industry, Urology, medicine.medical_treatment, medicine, business, Surgery
Published
2013

12. 1012 RISK FACTORS FOR CONVERSIONS AND POSTOPERATIVE COMPLICATIONS IN UROLOGIC LAPAROENDOSCOPIC SINGLE-SITE SURGERY (LESS): MULTI-INSTITUTIONAL ANALYSIS OF 1163 CASES

Author

Riccardo Autorino, Rachid Yakoubi, Koon Ho Rha, Robert J. Stein, Fernando J. Kim, Deok Hyun Han, Wesley M. White, Lee Richstone, Ithaar H. Darweesh, Evangelos Liatsikos, Georges-Pascal Haber, Luca Cindolo, Jens-Uwe Stolzenburg, Soroush Rais-Bahrami, Alessandro Volpe, Luigi Schips, Abhay Rane, Woong Kyu Han, Joo Yong Lee, Carlo Terrone, Panagiotis Kallidonis, Byong Chang Jeong, Wassim Bazzi, Seung Wook Lee, Salah Elsalmy, Paolo Fornara, Wilson Molina, Camilo Giedelman, Phillip Pierorazio, Sara Best, Bo Yang, Anibal W. Branco, Aly M. Abdel-Karim, Francesco Greco, Rene Sotelo, Sebastien Crouzet, Sun Yinghao, Mohamad Allaf, Jeffrey A. Cadeddu, and Jihad Kaouk

Subjects
Urology
Published
2012

21. 830 OUTCOMES OF LAPAROENDOSCOPIC SINGLE SITE PYELOPLASTY: A MULTI-INSTITUTIONAL CUMULATIVE ANALYSIS

Author

Rizkala, Emad, primary, Rais-Bahrami, Soroush, additional, Autorino, Riccardo, additional, Cadeddu, Jeffrey, additional, Bagrodia, Aditya, additional, Tugcu, Vulcan, additional, Kaouk, Jihad, additional, Kawauchi, Akihiro, additional, Abdel-Karim, Aly, additional, Elsalmy, Salah, additional, Ithaar, Derweesh, additional, George, Arvin, additional, Liss, Michael, additional, Haber, Georges-Pascal, additional, Richstone, Lee, additional, and Stein, Robert, additional

Published
2013
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22. Urological Laparoendoscopic Single Site Surgery: Multi-Institutional Analysis of Risk Factors for Conversion and Postoperative Complications

Author

Autorino, Riccardo, primary, Kaouk, Jihad H., additional, Yakoubi, Rachid, additional, Rha, Koon Ho, additional, Stein, Robert J., additional, White, Wesley M., additional, Stolzenburg, Jens-Uwe, additional, Cindolo, Luca, additional, Liatsikos, Evangelos, additional, Rais-Bahrami, Soroush, additional, Volpe, Alessandro, additional, Han, Deok Hyun, additional, Derweesh, Ithaar H., additional, Lee, Seung Wook, additional, Abdel-Karim, Aly M., additional, Branco, Anibal, additional, Greco, Francesco, additional, Allaf, Mohamad, additional, Sotelo, Rene, additional, Kallidonis, Panagiotis, additional, Jeong, Byong Chang, additional, Best, Sara, additional, Bazzi, Wassim, additional, Pierorazio, Phillip, additional, Elsalmy, Salah, additional, Rane, Abhay, additional, Han, Woong Kyu, additional, Yang, Bo, additional, Schips, Luigi, additional, Molina, Wilson R., additional, Fornara, Paolo, additional, Terrone, Carlo, additional, Giedelman, Camilo, additional, Lee, Joo Yong, additional, Crouzet, Sebastien, additional, Haber, Georges-Pascal, additional, Richstone, Lee, additional, Yinghao, Sun, additional, Kim, Fernando J., additional, and Cadeddu, Jeffrey A., additional

Published
2012
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24. 1012 RISK FACTORS FOR CONVERSIONS AND POSTOPERATIVE COMPLICATIONS IN UROLOGIC LAPAROENDOSCOPIC SINGLE-SITE SURGERY (LESS): MULTI-INSTITUTIONAL ANALYSIS OF 1163 CASES

Author

Autorino, Riccardo, primary, Yakoubi, Rachid, additional, Rha, Koon Ho, additional, Stein, Robert J., additional, Kim, Fernando J., additional, Han, Deok Hyun, additional, White, Wesley M., additional, Richstone, Lee, additional, Darweesh, Ithaar H., additional, Liatsikos, Evangelos, additional, Haber, Georges-Pascal, additional, Cindolo, Luca, additional, Stolzenburg, Jens-Uwe, additional, Rais-Bahrami, Soroush, additional, Volpe, Alessandro, additional, Schips, Luigi, additional, Rane, Abhay, additional, Han, Woong Kyu, additional, Lee, Joo Yong, additional, Terrone, Carlo, additional, Kallidonis, Panagiotis, additional, Jeong, Byong Chang, additional, Bazzi, Wassim, additional, Lee, Seung Wook, additional, Elsalmy, Salah, additional, Fornara, Paolo, additional, Molina, Wilson, additional, Giedelman, Camilo, additional, Pierorazio, Phillip, additional, Best, Sara, additional, Yang, Bo, additional, Branco, Anibal W., additional, Abdel-Karim, Aly M., additional, Greco, Francesco, additional, Sotelo, Rene, additional, Crouzet, Sebastien, additional, Yinghao, Sun, additional, Allaf, Mohamad, additional, Cadeddu, Jeffrey A., additional, and Kaouk, Jihad, additional

Published
2012
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32. EFFECTS OF M274773, A NEUROKININ-2 RECEPTOR ANTAGONIST, ON BLADDER FUNCTION IN CHRONICALLY SPINALIZED RATS.

Author

ALY M ABDEL-KARIM

Subjects
UROLOGY, CENTRAL nervous system, URINARY organs, BLADDER, MEDICINE
Abstract

PURPOSE:: Increased afferent nerve activity may have an important role in the pathogenesis of neurogenic detrusor overactivity. We tested the efficacy of the neuokinin-2 receptor antagonist M274773 ((S)-N-[2-(3,4-Dichlorophenyl)-4-[4-(2-oxoperhydro-pyrimidin-l-yl) piperidino]butyl]-N-methylbenzamide dihydrochloride) on neurogenic detrusor overactivity after spinal cord injury in rats.MATERIALS AND METHODS:: Included in this study were 48 adult Sprague-Dawley rats (Charles River, Montreal, Quebec, Canada). Six animals served as normal controls, while 32 underwent spinal cord transection at the 10th thoracic vertebra. Two weeks after spinal cord injury 6 animals underwent filling cystometrography to confirm neurogenic detrusor overactivity, while another 12 served as paraplegic controls. The remaining 24 paraplegic animals were used to test the drug and they were divided into 2 equal groups of 12. Group 1 received the drug at a dose of 0.3 mg/kg daily, while group 2 received a dose of 0.6 mg/kg daily. Each paraplegic control and treatment group was further subdivided into 2 subgroups of 6 rats each. In subgroup 1 filling cystometrography was done 3 weeks after spinal cord injury, while in subgroup 2 it was done 4 weeks after spinal cord injury.RESULTS:: Three weeks after spinal cord injury neurogenic detrusor overactivity developed in all paraplegic control animals with a mean bladder capacity ± SD of 0.7 ± 0.2 ml and a mean voiding pressure of 59 ± 14.2 cm H2O. Neurogenic detrusor overactivity resolved in 50% and 83% of the animals that received M274773 for 1 week at doses of 0.3 and 0.6 mg/kg daily, respectively. Mean cystometric bladder capacity was 1.2 ± 0.5 vs 1.3 ± 0.4 ml and mean voiding pressure was 46.1 ± 10.8 vs 40 ± 9.9 cm H2O in animals that received 0.3 vs 0.6 mg/kg daily, respectively. The drug produced better urodynamic results when given for 2 weeks rather than 1 week.CONCLUSIONS:: M274773 is effective for neurogenic detrusor overactivity after spinal cord injury in the rat. It may provide an alternative clinical treatment option for neurogenic detrusor overactivity and urgency/frequency syndrome. This new neurokinin-2 selective antagonist has time and dose response effects, which further suggests the potential for clinical application. [ABSTRACT FROM AUTHOR]

Published
2005
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