1. Prostate Specific Antigen and Prostate Cancer in Chinese Men Undergoing Initial Prostate Biopsies Compared with Western Cohorts
- Author
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Xu Gao, Pengfei Shao, Helmut Klocker, G. Bartsch, Freddie C. Hamdy, Ye Tian, Gilles Salama, Daniel M. Moreira, Dalin He, David E. Neal, Dingwei Ye, Dipen J. Parekh, Daniel Sjöberg, Yinghao Sun, Michael W. Kattan, J. Stephen Jones, Jonas Hugosson, Eric A. Klein, Yi-Ran Huang, Arnauld Villers, Hans Lilja, Chunxiao Liu, Rui Chen, Kexin Xu, Liqun Zhou, Qiang Fu, Donna P. Ankerst, Xin Gao, Jianquan Hou, Danfeng Xu, Monique J. Roobol, Liping Xie, Shancheng Ren, Fritz H. Schröder, Angel M. Cronin, Junhua Zheng, Qiang Ding, S.J. Freedland, Tiejun Pan, Jianlin Yuan, Qiang Wei, Andrew J. Vickers, Jenny L Donovan, Chuanliang Xu, Lulin Ma, Zhangqun Ye, Amine Benchikh, Wolfgang Horninger, and Zhongquan Sun
- Subjects
PCA3 ,Oncology ,medicine.medical_specialty ,Prostate biopsy ,medicine.diagnostic_test ,business.industry ,Urology ,030232 urology & nephrology ,Retrospective cohort study ,Rectal examination ,medicine.disease ,03 medical and health sciences ,Prostate-specific antigen ,Prostate cancer ,0302 clinical medicine ,medicine.anatomical_structure ,Prostate ,030220 oncology & carcinogenesis ,Internal medicine ,Biopsy ,Medicine ,business - Abstract
Purpose: We determined the characteristics of Chinese men undergoing initial prostate biopsy and evaluated the relationship between prostate specific antigen levels and prostate cancer/high grade prostate cancer detection in a large Chinese multicenter cohort.Materials and Methods: This retrospective study included 13,904 urology outpatients who had undergone biopsy for the indications of prostate specific antigen greater than 4.0 ng/ml or prostate specific antigen less than 4.0 ng/ml but with abnormal digital rectal examination results. The prostate specific antigen measurements were performed in accordance with the standard procedures at the respective institutions. The type of assay used was documented and recalibrated to the WHO standard.Results: The incidence of prostate cancer and high grade prostate cancer was lower in the Chinese cohort than the Western cohorts at any given prostate specific antigen level. Around 25% of patients with a prostate specific antigen of 4.0 to 10.0 ng/ml were found to h...
- Published
- 2017
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