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The hepatoprotective effect of leaf extract of Jatropha curcas L. was investigated against carbon tetrachloride (CC14)-induced acute hepatotoxicity in rats. Wistar albino rats were treated with pet, ether, alcoholic and aqueous leaf extract (200mg/kg, p.o.) for seven days along with CC14 on alternate days. Biochemical parameters such as serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TBL) were estimated. The extracts showed protective effect by lowering serum levels of various biochemical parameters in the selected model. These biochemical observations were supplemented with histopathological examination of liver sections. [ABSTRACT FROM AUTHOR]

The hepatoprotective effect of leaf extract of Jatropha curcas L. was investigated against carbon tetrachloride (CCl4)-induced acute hepatotoxicity in rats. Wistar albino rats were treated with pet. ether, alcoholic and aqueous leaf extract (200mg/kg , p.o.) for seven days along with CCl4 on alternate days. Biochemical parameters such as serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TBL) were estimated. The extracts showed protective effect by lowering serum levels of various biochemical parameters in the selected model. These biochemical observations were supplemented with histopathological examination of liver sections. [ABSTRACT FROM AUTHOR]