1. Effects of Electroacupuncture at Shangjuxu (ST 37) on Interleukin-1β and Interleukin-4 in the Ulcerative Colitis Model Rats
- Author
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Wen-feng Liao, Chu-tao Chen, Hong Zhang, Jie Yan, Qian-yun Yang, and Ping-guo Chen
- Subjects
Male ,medicine.medical_specialty ,Electroacupuncture ,interleukin-4 (IL-4) ,medicine.medical_treatment ,Interleukin-1beta ,interleukin-1β (IL-1β) ,Gastroenterology ,Random Allocation ,Internal medicine ,Shangjuxu (ST 37) ,medicine ,Animals ,Humans ,Rats, Wistar ,Colitis ,Interleukin 4 ,Medicine(all) ,business.industry ,General Medicine ,Enema ,medicine.disease ,Ulcerative colitis ,ulcerative colitis (UC) ,Rats ,Normal group ,Interleukin 1β ,Disease Models, Animal ,Cytokine ,Immunology ,Colitis, Ulcerative ,Interleukin-4 ,business ,Acupuncture Points - Abstract
Objective To probe into the mechanisms of electroacupuncture (EA) at Shangjuxu (ST 37) for treatment of the ulcerative colitis (UC). Methods Forty male Wistar rats were randomly divided into 4 groups: a normal group, a model group, a Shangjuxu group and a non-acupoint group, 10 rats in each group. The UC rat model was made with enema of trinitro-benzenesulfonic acid (TNBSA), and the changes of interleukin-1β (IL-1β) and interleukin-4 (IL-4) contents after EA at Shangjuxu (ST 37) were observed. Results EA at Shangjuxu (ST 37) could significantly decrease the IL-1β content and increase the IL-4 content in the colic tissues of the UC rats with significant differences as compared with the model group and the non-acupoint group ( P P Conclusion The mechanisms of EA at Shangjuxu (ST 37) for treatment of the UC rats is possibly related with the decrease of IL-1β, a inflammation-promoting cytokine, and the increase of IL-4, a anti-inflammatory cytokine.
- Published
- 2009
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