1. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice
- Author
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Saeko Onami, Hiroaki Suzuki, Hajime Iida, Hiroyuki Yoshimura, Hiroyuki Tsuji, Chigusa Okubo, Yuki Tomonari, Asuka Iwanaga, Seiji Otake, and Yurie Motohashi
- Subjects
0301 basic medicine ,Lung ,Butanone ,Pharmacology ,Toxicology ,medicine.disease_cause ,Pathology and Forensic Medicine ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,chemistry ,Benzo(a)pyrene ,030220 oncology & carcinogenesis ,High doses ,medicine ,Pyrene ,Dosimetry ,Carcinogenesis ,Carcinogen - Abstract
Some chemicals are known to be lung carcinogens in rodents. While many studies using two-stage models have administered medium or high doses to mice, few have tested lower doses. The dose dependence of urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P), three well-known lung carcinogens at high doses, has not been sufficiently reported in lower dose ranges. Our study evaluated the tumorigenicity of urethane, NNK, and B[a]P at 26 weeks after a single intraperitoneal administration of each compound within medium to low dose in male and/or female A/JJmsSlc (A/J) mice. Dose-dependent tumorigenesis was demonstrated histopathologically for the three compounds. These results suggested that the tumorigenicity of these chemicals is dose dependent in A/J mice, even at lower doses than previously reported.
- Published
- 2017
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