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Your search keyword '"Namakydoust A"' showing total 13 results
Start Over Author "Namakydoust A" Journal journal of thoracic oncology
13 results on '"Namakydoust A"'

1. SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas

Author

Rekhtman, Natasha, Montecalvo, Joseph, Chang, Jason C., Alex, Deepu, Ptashkin, Ryan N., Ai, Ni, Sauter, Jennifer L., Kezlarian, Brie, Jungbluth, Achim, Desmeules, Patrice, Beras, Amanda, Bishop, Justin A., Plodkowski, Andrew J., Gounder, Mrinal M., Schoenfeld, Adam J., Namakydoust, Azadeh, Li, Bob T., Rudin, Charles M., Riely, Gregory J., Jones, David R., Ladanyi, Marc, and Travis, William D.

Published
2020
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2. Targeting NFE2L2/KEAP1 Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228

Author

Paik, Paul K., primary, Fan, Pang-Dian, additional, Qeriqi, Besnik, additional, Namakydoust, Azadeh, additional, Daly, Bobby, additional, Ahn, Linda, additional, Kim, Rachel, additional, Plodkowski, Andrew, additional, Ni, Ai, additional, Chang, Jason, additional, Fanaroff, Rachel, additional, Ladanyi, Marc, additional, de Stanchina, Elisa, additional, and Rudin, Charles M., additional

Published
2022
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5. SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas

Author

Mrinal M. Gounder, Ni Ai, Natasha Rekhtman, Joseph Montecalvo, Andrew J. Plodkowski, Patrice Desmeules, Amanda Beras, William D. Travis, Marc Ladanyi, Achim A. Jungbluth, Gregory J. Riely, Adam J. Schoenfeld, Justin A. Bishop, Azadeh Namakydoust, Bob T. Li, Deepu Alex, Charles M. Rudin, Jennifer L. Sauter, Brie Kezlarian, Ryan Ptashkin, Jason C. Chang, and David R. Jones

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Lung Neoplasms, Thoracic, Cell, medicine.disease_cause, Article, 03 medical and health sciences, BRG1, 0302 clinical medicine, SMARCA4, Rhabdoid, Biomarkers, Tumor, Humans, Medicine, Lung, Thoracic Neoplasm, Mutation, business.industry, Lineage markers, Carcinoma, Smoking, DNA Helicases, Nuclear Proteins, Sarcoma, Thoracic Neoplasms, Sarcomatoid, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Immunohistochemistry, Undifferentiated carcinoma, business, Transcription Factors
Abstract

Introduction: Highly aggressive thoracic neoplasms characterized by SMARCA4 (BRG1) deficiency and undifferentiated round cell or rhabdoid morphology have been recently described and proposed to represent thoracic sarcomas. However, it remains unclear whether such tumors may instead represent sarcomatoid carcinomas, and how their clinicopathologic characteristics compare with those of nonsarcomatoid SMARCA4-deficient non–small cell lung carcinomas (SD-NSCC). Methods: We identified 22 SMARCA4-deficient thoracic sarcomatoid tumors (SD-TSTs) with round cell and/or rhabdoid morphology and 45 SD-NSCCs, and comprehensively analyzed their clinicopathologic, immunohistochemical, and genomic characteristics using 341–468 gene next-generation sequencing and other molecular platforms. Results: The relationship of SD-TSTs with NSCC was supported by (1) the presence of NSCC components juxtaposed with sarcomatoid areas in five cases, (2) focal expression of NSCC lineage markers TTF1 or p40 in four additional cases, (3) smoking history in all except one patient (mean = 51 pack-years), accompanied by genomic smoking signature, and (4) high tumor mutation burden (mean = 14.2 mutations per megabase) and mutations characteristic of NSCC in a subset. Compared with SD-NSCCs, SD-TSTs exhibited considerably larger primary tumor size (p < 0.0001), worse survival (p = 0.004), and more frequent presentation at younger age (30–50 years) despite heavier smoking history. Distinctive pathologic features of SD-TSTs included consistent lack of adhesion molecule claudin-4, SMARCA2 (BRM) codeficiency, and frequent expression of stem cell markers. Conclusions: SD-TSTs represent primarily smoking-associated undifferentiated/de-differentiated carcinomas rather than primary thoracic sarcomas. Despite their histogenetic relationship with NSCC, these tumors have unique clinicopathologic characteristics, supporting their recognition as a distinct entity. Further studies are warranted to determine therapeutic approaches to this novel class of exceptionally aggressive thoracic tumors.

Published
2020
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6. Targeting NFE2L2/KEAP1Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228

Author

Paik, Paul K., Fan, Pang-Dian, Qeriqi, Besnik, Namakydoust, Azadeh, Daly, Bobby, Ahn, Linda, Kim, Rachel, Plodkowski, Andrew, Ni, Ai, Chang, Jason, Fanaroff, Rachel, Ladanyi, Marc, de Stanchina, Elisa, and Rudin, Charles M.

Abstract

Increased insight into the mutational landscape of squamous cell lung cancers (LUSCs) in the past decade has not translated into effective targeted therapies for patients with this disease. NRF2, encoded by NFE2L2, and its upstream regulator, KEAP1, control key aspects of redox balance and are frequently mutated in NSCLCs.

Published
2023
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7. MA06.08 A Safety Study of Avelumab plus SBRT in Malignant Mesothelioma

Author

Rimner, A., primary, Yorke, E., additional, Gelblum, D., additional, Shepherd, A., additional, Guttmann, D., additional, Iqbal, A., additional, Daly, R., additional, Offin, M., additional, Fiore, J., additional, Namakydoust, A., additional, Li, H., additional, Mccune, M., additional, Gelb, E., additional, Taunk, N., additional, Von Reibnitz, D., additional, Adusumilli, P., additional, Center, M.S.K., additional, and Zauderer, M., additional

Published
2021
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9. A07 The Genomic Landscape of SMARCA4 Alterations and Association with Patient Outcomes in Lung Cancer

Author

Schoenfeld, A.J., primary, Montecalvo, J., additional, Namakydoust, A., additional, Lavery, J., additional, Bandlamudi, C., additional, Rizvi, H., additional, Paul, S., additional, Arcila, M., additional, Chang, J., additional, Sauter, J., additional, Beras, A., additional, Ladanyi, M., additional, Taylor, B., additional, Donoghue, M., additional, Heller, G., additional, Hellmann, M., additional, Rekhtman, N., additional, and Riely, G., additional

Published
2020
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10. MA06.08 A Safety Study of Avelumab plus SBRT in Malignant Mesothelioma

Author

A. Rimner, E. Yorke, D. Gelblum, A. Shepherd, D. Guttmann, A. Iqbal, R. Daly, M. Offin, J. Fiore, A. Namakydoust, H. Li, M. Mccune, E. Gelb, N. Taunk, D. Von Reibnitz, P. Adusumilli, M.S.K. Center, and M. Zauderer

Subjects
Pulmonary and Respiratory Medicine, Oncology, Avelumab, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Mesothelioma, business, medicine.disease, medicine.drug
Published
2021
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11. A07 The Genomic Landscape of SMARCA4 Alterations and Association with Patient Outcomes in Lung Cancer

Author

Jason C. Chang, Matthew D. Hellmann, Azadeh Namakydoust, Hira Rizvi, G. J. Riely, Chaitanya Bandlamudi, Maria E. Arcila, B.S. Taylor, S. Paul, Adam J. Schoenfeld, Amanda Beras, G. Heller, M. Ladanyi, M. Donoghue, J. Lavery, Natasha Rekhtman, Joseph Montecalvo, and Jennifer L. Sauter

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, Association (object-oriented programming), Internal medicine, SMARCA4, medicine, business, Lung cancer, medicine.disease
Published
2020
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12. P1.01-122 A Clinical Utility Study of Plasma DNA Next Generation Sequencing Guided Treatment of Uncommon Drivers in Advanced Non-Small-Cell Lung Cancers

Author

Tu, H., primary, Xu, C., additional, Tong-Li, C., additional, Offin, M., additional, Razavi, P., additional, Schapira, E., additional, Namakydoust, A., additional, Lee, A., additional, Pavlakis, N., additional, Clarke, S., additional, Diakos, C., additional, Chan, D., additional, Myers, M., additional, Makhnin, A., additional, Jain, H., additional, Martinez, A., additional, Iqbal, Z., additional, Adamski, A., additional, Li, H., additional, Hernandez, J., additional, Watford, S., additional, Hosseini, A., additional, Shaffer, T., additional, Lim, L., additional, Li, M., additional, Drilon, A., additional, Ladanyi, M., additional, Arcila, M., additional, Rusch, V., additional, Jones, D., additional, Rudin, C., additional, Rimner, A., additional, Isbell, J., additional, and Li, B., additional

Published
2019
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13. P1.01-122 A Clinical Utility Study of Plasma DNA Next Generation Sequencing Guided Treatment of Uncommon Drivers in Advanced Non-Small-Cell Lung Cancers

Author

M. Ladanyi, Z. Iqbal, Alex Makhnin, Mackenzie L. Myers, Adrian Lee, Azadeh Namakydoust, Maria E. Arcila, Michael Offin, H. Jain, Stephen Clarke, Connie I. Diakos, Andres Martinez, Jennifer Hernandez, E. Schapira, David Chan, Chongrui Xu, S. Watford, Pedram Razavi, David R. Jones, H. Li, Mark Li, A. Hosseini, Tristan Shaffer, James M. Isbell, Ariana Adamski, Charles M. Rudin, Hai-Yan Tu, Lee P. Lim, Andreas Rimner, C. Tong-Li, A. Drilon, Bob T. Li, V. Rusch, and Nick Pavlakis

Subjects
Pulmonary and Respiratory Medicine, Lung, medicine.anatomical_structure, Oncology, business.industry, Plasma dna, Cancer research, Medicine, Non small cell, business, DNA sequencing
Published
2019
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