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Aim: This study was planned to investigate the effects of sciatic-femoral-nerve-block and spinal-anaesthesia on I/R injury under the tourniquet. Material and Methods: Thirty-one patients undergoing to knee arthroscopy; ASA I-II and 18-60 year-old were included and organized randomly into two groups. Femoral-sciatic-nerve-blocks was performed under guidance of ultrasonography and a nerve stimulator in patients of Group I (n=15). For the femoral-sciatic-nerve-blocks, 20 mL of 0.5 % bupivacaine and 20 mL of 2 % prilocaine (40 mL totally) were mixtured. Twenty ml of it was injected into each of the femoral and sciatic nerves. Spinal-anaesthesia was performed at L4-5 level by using 12.5 mg of 0.5 % bupivacaine in patients of group II (n=16). After then the tourniquet was inflated to 300 mmHg for each patient. Blood samples were taken at different times; before the anaesthesia (T0), before the beginning of the surgery and inflation of tourniquet (T1), 30 minutes after tourniquet (T2), and 10 minutes after deflation of tourniquet (T3) and lipid peroxidase (LPO) and total antioxidant capacity (AOK) levels were analyzed. Results: There were no significant differences in the levels of LPO and AOK between the groups. Within group comparisons, levels of AOK were found to decreased significantly at all times than T0 in both groups (p<0.008). The levels of LPO showed no differences in all times of group II however there were significant differences in group I between T0-T2, T0-T3, T1-T2, T1-T3 (p<0.008). Conclusion: The oxidative stress and antioxidant potentials after I/R injury were found to be similar at both of the anaesthesia techniques. [ABSTRACT FROM AUTHOR]