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La2O3/Co3O4 nanocomposite was synthesized and then used for the modification of screen-printed electrode (SPE) prior to the electrochemical determination of sertraline. A significant increment in peak current response was observed and peak potential also shifted towards less positive potentials showing the facilitated oxidation procedure at surface of modified SPE (La2O3/ /Co3O4/SPE). The quantitative determination of sertraline was carried out by using different pulse voltammetry and the anodic peak current was found to increase with increasing sertraline concentration in the linear range of 5.0400.0 μM with limit of detection as 1.0 μM. The prepared La2O3/Co3O4/SPE has been successfully used for detecting sertraline in sertraline tablet and urine samples with excellent recoveries.

In the present work, a rapid and sensitive detection of the amlodipine (AML) based on the modified screen printed carbon electrode (SPCE) is developed. At first, SPCE was modified with magnetic core shell manganese ferrite nanoparticles (MCSNP). Cyclic voltammetry (CV) was used to study the electrochemical behaviour of AML and its determination was conducted by applying differential pulse voltammetry (DPV). The results were showed that, the modified SPCE in comparison with unmodified SPCE exhibited the enhanced electrocatalytic activity toward the oxidation of AML. A single irreversible oxidation peak was observed at a potentials of 600 and 725 mV (on the scale of Ag/AgCl electrode) on the modified SPCE and unmodified SPCE, respectively. Under the optimized conditions, the anodic peak current of AML recorded by DPV varies linearly with AML concentration in the range 0.5–400 μM with a detection limit of 0.1 μM. The modified SPCE was used for the quantitative analysis of AML in AML tablet and urine samples and the results indicated the feasibility of the developed method for AML analysis in routine detection.

A carbon paste electrode (CPE) was modified with N-(ferrocenylmethylidene) fluorene-2-amine and graphene/ZnO nanocomposite. The electrooxidation of captopril (CAP) at the surface of the modified electrode was studied using electrochemical approaches. The electrochemical study of the modified electrode, as well as its efficiency for the electrocatalytic oxidation of captopril, is described. The electrode was used to study the electrocatalytic oxidation of captopril, by cyclic voltammetry (CV), chronoamperometry (CHA) and differential pulse voltammetry (DPV) as diagnostic techniques. It has been found that the oxidation of captopril at the surface of modified electrode occurs at a potential of about 340 mV less positive than that of an unmodified CPE. DPV of captopril at the electrochemical sensor exhibited two linear dynamic ranges (0.1–100.0 and 100.0–800.0 μM) with a detection limit (3σ) of 0.05 μM.

A Cu/TiO2 nanocomposite modified glassy carbon electrode (Cu/ /TiO2/GCE) was fabricated to detect methyldopa by cyclic voltammetry (CV) and different pulse voltammetry (DPV) methods. Compared with bare GCE, the Cu/TiO2/GCE exhibited excellent electrochemical activity for the oxidation of methyldopa. Using DPV technique, the calibration curves for methyldopa were found linear in the concentration range of 0.5–800.0 μM and the detection limit (S/N = 3) was calculated to be 0.23 μM. Additionally, the prepared electrochemical sensor of Cu/TiO2/GCE demonstrated a practical feasibility in methyldopa tablets and in urine samples analysis.