1. Neuropsychiatric characteristics of GBA-associated Parkinson disease
- Author
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Susan Bressman, Nir Giladi, Joan Miravite, Jose Cabassa, Brooke Johannes, Laurie J. Ozelius, Matthew J. Barrett, Roberto A. Ortega, Karen Marder, William C. Nichols, Jeannie Soto-Valencia, Harini Sarva, Rivka Sachdev, William Severt, Rachel Saunders-Pullman, Nancy Doan, Matthew Swan, Vicki Shanker, Sarah Boschung, Andres Deik, and Deborah Raymond
- Subjects
Male ,0301 basic medicine ,Heterozygote ,medicine.medical_specialty ,Time Factors ,Comorbidity ,Disease ,Anxiety ,Neuropsychological Tests ,Severity of Illness Index ,Article ,Tertiary Care Centers ,Disability Evaluation ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Internal medicine ,Severity of illness ,medicine ,Humans ,Genetic Predisposition to Disease ,Risk factor ,Genetic Association Studies ,Depression (differential diagnoses) ,Aged ,Psychiatric Status Rating Scales ,Depression ,beta-Glucosidase ,Beck Depression Inventory ,Montreal Cognitive Assessment ,Parkinson Disease ,Middle Aged ,medicine.disease ,030104 developmental biology ,Neurology ,Mutation ,Glucosylceramidase ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Mutations in GBA1 are a well-established risk factor for Parkinson disease (PD). GBA-associated PD (GBA-PD) may have a higher burden of nonmotor symptoms than idiopathic PD (IPD). We sought to characterize the relationship between GBA-PD and neuropsychiatric symptoms. Subjects were screened for common GBA1 mutations. GBA-PD (n=31) and non-carrier (IPD; n=55) scores were compared on the Unified Parkinson Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), and the State-Trait Anxiety Index (STAI). In univariate comparisons, GBA-PD had a greater prevalence of depression (33.3%) versus IPD (13.2%) (p
- Published
- 2016
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