1. Clinical management of chronic inflammatory demyelinating polyneuropathy (CIDP) in Europe and India: An exploratory study
- Author
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Man Mohan Mehndiratta, Martin K.R. Svačina, Christian A. Vedeler, Abhijeet R. Joshi, Yogesh Sharma, Helmar C. Lehmann, Ilja Bobylev, Hauke Wüstenberg, Gina Remke, Ines Klein, and Alina Sprenger
- Subjects
medicine.medical_specialty ,Standard of care ,Biopsy ,Exploratory research ,Chronic inflammatory demyelinating polyneuropathy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Psychological strain ,030212 general & internal medicine ,Peripheral Nerves ,Genetic testing ,Nerve biopsy ,medicine.diagnostic_test ,business.industry ,Immunoglobulins, Intravenous ,medicine.disease ,Europe ,Neurology ,Polyradiculoneuropathy, Chronic Inflammatory Demyelinating ,Cohort ,Prednisolone ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder causing inflammatory demyelination of peripheral nerves and consecutive disability. Diagnostic criteria and treatments are well established, but it is unknown how clinical practice may differ in different geographical regions. In this multicentre study, clinical management of CIDP was compared in 44 patients from Germany, India and Norway regarding diagnostic and therapeutic procedures. All centres used EFNS/PNS diagnostic criteria for CIDP but diagnostic workup varied regarding screening for infectious diseases, genetic testing and nerve biopsy. Intravenous immunoglobulin and prednisolone were the most common therapies in all centres with differences in indication and dosage. Patients from the Indian cohort were the most severely affected with less diverse therapeutic approaches, whereas psychological strain did not differ significantly from the two other cohorts. Our exploratory study discloses an unaddressed issue in management of CIDP that should be further investigated to optimise standard of care for CIDP worldwide.
- Published
- 2021