1. A poxvirus of primates. II. Immunology.
- Author
-
Nicholas AH
- Subjects
- Animals, California, Cells, Cultured virology, Complement Fixation Tests, Humans, Monkeypox virus immunology, Neutralization Tests, Oregon, Suipoxvirus immunology, Texas, Vaccinia virus immunology, Yaba monkey tumor virus immunology, Antibodies, Viral immunology, Antigens, Viral immunology, Poxviridae immunology, Poxviridae Infections immunology, Primates virology
- Abstract
OrTeCa poxvirus shares antigens with Yaba virus, as evidenced by two-way crossreactions in complement-fixation and neutralization tests. Antibodies produced by vaccinia and monkeypox viruses showed weak complement-fixation reactions with OrTeCa viral antigen, but neutralization reactions were negative and cross protection in vivo was not demonstrated. OrTeCa and Yaba virus antisera both contained complement-fixing and neutralizing antibodies against swinepox virus, but swinepox antiserum had no antibodies to any other poxvirus. Long-lasting immunity to the OrTeCa pox disease was produced in monkeys and man by spontaneous infection or vaccination with OrTeCa poxvirus. Complement-fixing antibody titers could be measured in convalescence, but tended to drop to low levels or disappear thereafter. In contrast, neutralizing antibody titers remained high for 3 years, and monkeys that were challenged with OrTeCa virus were reFractory to a second infection.
- Published
- 1970