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Start Over Author "Jutarat Praparattanapan" Journal journal of the international aids society
2 results on '"Jutarat Praparattanapan"'

1. HIV multi‐drug resistance at first‐line antiretroviral failure and subsequent virological response in Asia

Author

Awachana Jiamsakul, Somnuek Sungkanuparph, Matthew Law, Rami Kantor, Jutarat Praparattanapan, Patrick CK Li, Praphan Phanuphak, Tuti Merati, Winai Ratanasuwan, Christopher KC Lee, Rossana Ditangco, Mahiran Mustafa, Thida Singtoroj, Sasisopin Kiertiburanakul, and on behalf of the TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER‐M)

Subjects
HIV, resource‐limited, resistance, mutations, failure, Immunologic diseases. Allergy, RC581-607
Abstract

Introduction First‐line antiretroviral therapy (ART) failure often results from the development of resistance‐associated mutations (RAMs). Three patterns, including thymidine analogue mutations (TAMs), 69 Insertion (69Ins) and the Q151M complex, are associated with resistance to multiple‐nucleoside reverse transcriptase inhibitors (NRTIs) and may compromise treatment options for second‐line ART. Methods We investigated patterns and factors associated with multi‐NRTI RAMs at first‐line failure in patients from The TREAT Asia Studies to Evaluate Resistance – Monitoring study (TASER‐M), and evaluated their impact on virological responses at 12 months after switching to second‐line ART. RAMs were compared with the IAS‐USA 2013 mutations list. We defined multi‐NRTI RAMs as the presence of either Q151M; 69Ins; ≥2 TAMs; or M184V+≥1 TAM. Virological suppression was defined as viral load (VL) 2 years (OR=6.25, 95% CI [2.39–16.36], p

Published
2014
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2. HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia

Author

Christopher K C Lee, Sasisopin Kiertiburanakul, Awachana Jiamsakul, Thida Singtoroj, Praphan Phanuphak, Rami Kantor, Tuti Parwati Merati, Winai Ratanasuwan, Matthew Law, Rossana Ditangco, Mahiran Mustafa, Somnuek Sungkanuparph, Patrick C.K. Li, and Jutarat Praparattanapan

Subjects
Adult, Male, medicine.medical_specialty, Asia, Time Factors, Anti-HIV Agents, First line, Molecular Sequence Data, Human immunodeficiency virus (HIV), HIV Infections, Drug resistance, medicine.disease_cause, Medication Adherence, Virological response, resistance, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Drug Resistance, Multiple, Viral, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Treatment Failure, 0303 health sciences, 030306 microbiology, business.industry, Public Health, Environmental and Occupational Health, HIV, Sequence Analysis, DNA, Resistance mutation, medicine.disease, mutations, 3. Good health, failure, CD4 Lymphocyte Count, Regimen, Infectious Diseases, resource-limited, Immunology, Mutation, Female, business, Viral load, Research Article
Abstract

Introduction First-line antiretroviral therapy (ART) failure often results from the development of resistance-associated mutations (RAMs). Three patterns, including thymidine analogue mutations (TAMs), 69 Insertion (69Ins) and the Q151M complex, are associated with resistance to multiple-nucleoside reverse transcriptase inhibitors (NRTIs) and may compromise treatment options for second-line ART. Methods We investigated patterns and factors associated with multi-NRTI RAMs at first-line failure in patients from The TREAT Asia Studies to Evaluate Resistance – Monitoring study (TASER-M), and evaluated their impact on virological responses at 12 months after switching to second-line ART. RAMs were compared with the IAS-USA 2013 mutations list. We defined multi-NRTI RAMs as the presence of either Q151M; 69Ins; ≥2 TAMs; or M184V+≥1 TAM. Virological suppression was defined as viral load (VL) 2 years (OR=6.25, 95% CI [2.39–16.36], p

Published
2014

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