1. Antiretroviral treatment and quality of life in Africans living with HIV: 12-month follow-up in Burkina Faso
- Author
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Didier K. Ekouevi, Elias Dah, Jean Charlemagne Kondombo, Franck Garanet, Eric Balestre, Antoine Jaquet, Jean Claude Azani, François Dabis, Réné Bognounou, Joseph Y Drabo, Jaquet, Antoine, Epidémiologie et Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2, Service de Médecine interne, Centre Hospitalier Universitaire Yalgado Ouédraogo (CHUYO), Programme PACCI, Centre Hospitalier Universitaire [Treichville] (CHU), Programme PAC-CI, CHU de Treichville, Centre médical associatif African Association Solidarity (AAS), Centre médical avec antenne chirurgicale de Pisssy, National Cancer Institute (NCI), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institute of Allergy and Infectious Diseases (NIAID) (grant no 5U01AI069919)., and for the IeDEA West Africa collaboration
- Subjects
Adult ,Male ,antiretroviral treatment ,sub-Saharan Africa ,Pediatrics ,medicine.medical_specialty ,Drug-Related Side Effects and Adverse Reactions ,Urban Population ,Anti-HIV Agents ,Population ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Quality of life ,Interquartile range ,Antiretroviral Therapy, Highly Active ,Surveys and Questionnaires ,Burkina Faso ,Antiretroviral treatment ,Humans ,Medicine ,030212 general & internal medicine ,education ,education.field_of_study ,business.industry ,030503 health policy & services ,Public Health, Environmental and Occupational Health ,Middle Aged ,medicine.disease ,Mental health ,Antiretroviral therapy ,3. Good health ,Infectious Diseases ,quality of life ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,HIV/AIDS ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,0305 other medical science ,business ,Follow-Up Studies ,Research Article - Abstract
Introduction: The scale-up of highly active antiretroviral therapy (HAART) has led to a significant improvement in survival of the HIV-positive patient but its effects on health-related quality of life (HRQOL) are less known and context-dependent. Our aim was to assess the temporal changes and factors associated with HRQOL among HIV-positive adults initiating HAART in Burkina Faso. Methods: HIV-positive people initiating HAART were prospectively included and followed over a one-year period in three HIV clinics of Ouagadougou. HRQOL was assessed at baseline and at each follow-up visit using physical (PHS) and mental (MHS) summary scores derived from the Medical Outcome Study 36-Item short-form health survey (MOS SF-36) questionnaire. Toxicity related to HAART modification and self-reported symptoms were recorded during follow-up visits. Determinants associated with baseline and changes in both scores over a one-year period were assessed using a mixed linear model. Results: A total of 344 patients were included. Their median age at baseline was 37 years [interquartile range (IQR) 30-44] and their median CD4 count was 181 cells/mm 3 (IQR 97-269). The mean [standard deviation (SD)] PHS score increased from 45.4 (11.1) at baseline to 60.0 (3.1) at 12 months ( p
- Published
- 2013