1. Effect of a brief alcohol counselling intervention on HIV viral suppression and alcohol use among persons with HIV and unhealthy alcohol use in Uganda and Kenya: a randomized controlled trial
- Author
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Puryear, Sarah B, Mwangwa, Florence, Opel, Fred, Chamie, Gabriel, Balzer, Laura B, Kabami, Jane, Ayieko, James, Owaraganise, Asiphas, Kakande, Elijah, Agengo, George, Bukusi, Elizabeth, Kabageni, Stella, Omoding, Daniel, Bacon, Melanie, Schrom, John, Woolf‐King, Sarah, Petersen, Maya L, Havlir, Diane V, Kamya, Moses, and Hahn, Judith A
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Clinical Research ,Women's Health ,Infectious Diseases ,Clinical Trials and Supportive Activities ,Screening And Brief Intervention For Substance Abuse ,Prevention ,Sexually Transmitted Infections ,HIV/AIDS ,Good Health and Well Being ,Humans ,Male ,Female ,HIV Infections ,Alcoholism ,Uganda ,Kenya ,Counseling ,Ethanol ,HIV ,viral suppression ,alcohol use ,brief counselling intervention ,sub-Saharan Africa ,randomized controlled trial ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences ,Clinical sciences ,Epidemiology ,Public health - Abstract
IntroductionUnhealthy alcohol use significantly contributes to viral non-suppression among persons with HIV (PWH). It is unknown whether brief behavioural interventions to reduce alcohol use can improve viral suppression among PWH with unhealthy alcohol use in sub-Saharan Africa (SSA).MethodsAs part of the SEARCH study (NCT04810650), we conducted an individually randomized trial in Kenya and Uganda of a brief, skills-based alcohol intervention among PWH with self-reported unhealthy alcohol use (Alcohol Use Disorders Identification Test-Consumption [AUDIT-C], prior 3 months, ≥3/female; ≥4/male) and at risk of viral non-suppression, defined as either recent HIV viral non-suppression (≥400 copies/ml), missed visits, out of care or new diagnosis. The intervention included baseline and 3-month in-person counselling sessions with interim booster phone calls every 3 weeks. The primary outcome was HIV viral suppression (200 ng/ml (RR 0.97, 95% CI: 0.92-1.02).ConclusionsIn a randomized trial of 401 PWH with unhealthy alcohol use and risk for viral non-suppression, a brief alcohol intervention reduced unhealthy alcohol use but did not affect viral suppression at 24 weeks. Brief alcohol interventions have the potential to improve the health of PWH in SSA by reducing alcohol use, a significant driver of HIV-associated co-morbidities.
- Published
- 2023