Search

Tuberculosis (TB) remains an important infectious disease in Taiwan. To control TB effectively, the Taiwan Centers for Disease Control implemented the National Tuberculosis Program (NTP) in 2006, modeled on the World Health Organization global TB control program. The goal of the program was to reduce the number of TB cases by half within a decade. This study was designed to describe the epidemiology of TB in Taiwan, and to evaluate the preliminary effectiveness of the NTP. Methods: We conducted a retrospective study of data from the National Tuberculosis Registry System collected between 2002 and 2008. Demographics, geographic distribution of disease, and change in rates of TB incidence and mortality were analyzed. Results: From 2002 to 2008, new TB cases declined from 16,758 to 14,265, and incidence decreased from 75 per 100,000 population to 62 per 100,000 population. More than 50% of new cases occurred among elderly adults. Over the study period, TB mortality decreased from 5.7 per 100,000 population to 3.3 per 100,000 population, with over half of TB deaths occurring among patients aged ≥ 65 years. Since the NTP was implemented, from 2005 to 2008, TB incidence and mortality declined by 14% and 23%, respectively. Conclusion: TB-associated incidence and mortality decreased over the course of the study. Nevertheless, there continue to be high-incidence areas that show the opposite trend; these areas should strive to improve case management and consultation. In the most populous districts, rigorous surveillance is necessary to track incidence and mortality rate fluctuations.

Assignment of underlying cause of death (UCOD) might be inconsistent among coders if physicians do not properly record cause of death on death certificates. This study aimed to assess the changes in the quality of tuberculosis-related UCOD assignment in Taiwan after interventions by the Center for Disease Control (CDC). Methods: The reference (gold standard) we used to assess the quality of UCOD assignment by coders was the UCOD selected by the Automated Classification of Medical Entities (ACME) computer program. The agreement, overand under-coding rates between coders and the reference were calculated by years before and after the CDC interventions. Results: An abrupt decrease in tuberculosis death rates according to the UCOD assigned by coders was noted from 2003 to 2004, but no such decrease was noted according to the reference. The agreement in UCOD assignments between coders and ACME decreased from 0.75 in 2001 to 0.67 in 2005. We found a significant decrease in the over-coding rate from 0.21 in 2003 to 0.11 in 2004, and a prominent increase in under-coding rates from 0.08 in 2003 to 0.24 in 2004. Conclusion: The abrupt decrease in the official published tuberculosis mortality rate from 2003 to 2004 was due to significant changes in the practice of UCOD assignment of official coders, which might have been a response to interventions initiated by the CDC.