Search

Your search keyword '"Chang SHU"' showing total 24 results
Start Over Author "Chang SHU" Journal journal of the formosan medical association
24 results on '"Chang SHU"'

24. Differences in oral habit and lymphocyte subpopulation affect malignant transformation of patients with oral precancer.

Author

Chien-Yang Yeh, Chien-Ling Lin, Mei-Chi Chang, Hsin-Ming Chen, Seng-Heng Kok, Shu-Hui Chang, Ying-Shiung Kuo, Liang-Jiunn Hahn, Chiu-Po Chan, Jang-Jaer Lee, Jiiang-Huei Jeng, Yeh, Chien-Yang, Lin, Chien-Ling, Chang, Mei-Chi, Chen, Hsin-Ming, Kok, Seng-Heng, Chang, Shu-Hui, Kuo, Ying-Shiung, Hahn, Liang-Jiunn, and Chan, Chiu-Po

Subjects
ORAL habits, LYMPHOCYTES, PRECANCEROUS conditions, CYTOMETRY, PATIENTS, CANCER treatment, B cells, BETEL palm, COMPARATIVE studies, ALCOHOL drinking, KILLER cells, RESEARCH methodology, MEDICAL cooperation, MOUTH tumors, RESEARCH, SMOKING, SQUAMOUS cell carcinoma, EVALUATION research, LYMPHOCYTE subsets
Abstract

Background/purpose: In Taiwan, the combination of betel quid chewing, alcohol consumption, and smoking habits increases oral cancer risk by 123-fold compared to persons without these habits. Lymphocyte populations in patients may potentially affect the malignant transformation of oral precancer.Methods: A total of 28 patients with oral precancer from our previous cohort were enrolled in this study, and their personal information and oral habits were documented. Their lymphocyte populations (CD4+, CD8+, CD19+, and CD56+) and activation markers (CD25 and CD69) were determined by flow cytometry from 1999 to 2004. After follow up till December 2014, data of patients with/without malignant transformation were recorded, and the relation between oral habits and percentage of initial lymphocyte markers was evaluated using the Student t test and Fisher's exact test.Results: Ten precancer patients developed oral squamous cell carcinoma with a mean period of malignant transformation of 6.8 ± 2.1 years. Patients with malignant transformation had a mean age of 48.4 ± 5.0 years (n = 10), relatively more than that of patients without malignant transformation (41.6 ± 6.3 years, n = 18) (p < 0.05). An increase was noted in the population of peripheral blood mononuclear cells expressing CD4+CD69+, CD19+CD69+, and CD56+CD69+ (p < 0.05) in precancer patients with malignant transformation. Alcohol consumption showed an association with the malignant transformation of patients with precancer (p = 0.030), whereas betel quid and smoking showed little effect.Conclusion: These results suggest that age, alcohol consumption, and early activation of T cells, B cells, and natural killer cells are crucial in the malignant transformation of oral precancer. Analysis of patient's lymphocyte populations may help predict the malignant transformation of oral precancer. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results