1. Low bone mineral density in early pubertal transgender/gender diverse youth: Findings from the Trans Youth Care Study
- Author
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Lee, Janet Y, Finlayson, Courtney, Olson-Kennedy, Johanna, Garofalo, Robert, Chan, Yee-Ming, Glidden, David V, and Rosenthal, Stephen M
- Subjects
Clinical Research ,Pediatric ,Contraception/Reproduction ,Sexual and Gender Minorities (SGM/LGBT*) ,Osteoporosis ,transgender youth ,gender-affirming medical treatment ,gonadotropin-releasing hormone agonists ,bone mineral density ,DXA ,bone QCT - Abstract
ContextTransgender youth may initiate GnRH agonists (GnRHa) to suppress puberty, a critical period for bone-mass accrual. Low bone mineral density (BMD) has been reported in late-pubertal transgender girls before gender-affirming therapy, but little is known about BMD in early-pubertal transgender youth.ObjectiveTo describe BMD in early-pubertal transgender youth.DesignCross-sectional analysis of the prospective, observational, longitudinal Trans Youth Care Study cohort.SettingFour multidisciplinary academic pediatric gender centers in the United States.ParticipantsEarly-pubertal transgender youth initiating GnRHa.Main outcome measuresAreal and volumetric BMD Z-scores.ResultsDesignated males at birth (DMAB) had below-average BMD Z-scores when compared with male reference standards, and designated females at birth (DFAB) had below-average BMD Z-scores when compared with female reference standards except at hip sites. At least 1 BMD Z-score was
- Published
- 2020