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Objectives: In this study for surveying the relation between exercise and immune cell, we examine the effect of Effect of 8 weeks endurance training on immune system cell changes with recovery period. Study design: Experimental study Methods: participant of this research including health and yang males that were randomized divided into two groups :( ETG) endurance training groups with 15 men; and (CG) 13 men in to control group. Different factor of anthropometric characteristics (i.e. age, weight & height) and also white blood cell (i.e. lymphocyte, neutrophils, monocytes) were experimented. In this study, subjects, runs on a treadmill for 15-30 min at 50 % - 70% maximal Heart rate for 8 weeks, with Venous blood sample was taken at pre, post and at 24- hours and 48-hours after exercise. For data analyze, we used of one -way using repeated-measurements ANOVA, in SPSS12. And also Significance was evaluated as P < 0.05.In addition, all values are expressed as mean ± standard deviation. Results: we found that lymphocyte level increased after 4th week and 48h-recovery, but decreased after 8th week (Mid-exercise), and 24h- recovery in exercise group. Also levels of Neutrophils and Monocytes decreased after after 4th week (Mid-exercise), post- exercise (8th week), 24h- recovery and 48h-recoveries in exercise group. Conclusion: These data demonstrate that a period endurance exercise leads to Levels changes of leukocytes after exercise and recovery period, but these changes not significant.