1. Multi-gram Preparation of 7-Nitroquinoxalin-2-amine
- Author
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Eliezer J. Barreiro, Fernando Rodrigues de Sá Alves, Stefan Laufer, Daniel N. do Amaral, and Lídia Moreira Lima
- Subjects
0301 basic medicine ,Regioselectivity ,General Chemistry ,Combinatorial chemistry ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,Quinoxaline ,Column chromatography ,chemistry ,law ,Amine gas treating ,Crystallization ,Gram - Abstract
Methodologies to obtain quinoxaline compounds regioselectively are rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives are desirable to explore the entire potential of these scaffolds for academic and/or commercial application. A facile and multi-gram methodology is described to obtain compound 7-nitroquinoxalin-2-amine using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatography.
- Published
- 2017
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