Search

The present study evaluated the analgesic, anti-inflammatory and antioxidant activities of Alternanthera pungens kunth.The ethanolic extract of Alternanthera pungens (EAP) showed analgesic effects by exerting ameliorated reaction time 40.79% and 44.74% at a dose of 250 and 500 mg/kg,respectively, whereas standard was 41.78% by the hot plate test. Results of writhing inhibition were statistically significant (p <0.05) when compared to control. In addition to that, anti-inflammatory effects were also evaluated against denaturation of protein and the result was significant. Scavenging activity of EAP was 80.95% at the concentration of 800μg/mL. Moreover, HPLC-DAD analysis of EAP was also carried out to determine the presence of phenolic constituents & noted the presence of epicatechin,vanillin, p-coumaric acid etc. These studies inferred that EAP possesses analgesic, antiinflammatory and antioxidant potential which might be due to presence of phytochemicals like flavonoids, tannins and phenolic compounds. [ABSTRACT FROM AUTHOR]

Six coumarins, one benzene, one flavone, one acridone, one limonoid, one triterpene and two phytosterol derivatives were isolated from the methanol, ethanol and chloroform leaf extracts of Citrus assamensis. Extensive spectroscopic studies, including high field 'H NMR and 13C NMR analyses, allowed the identification of thirteen known compounds as bergapten (1), umckalin (2), citropten (3), 4-hydroxybenzaldehyde (4), bergamottin (5), ß-amyrin (6), umbeliferone (7), scopoletin (8), citrusinol (9), citracridone-III (10), limonin(ll), stigmasterol (12), and ß-sitosterol (13). The identity of these compounds was confirmed by comparison with published data as well as co-TLC with authentic samples. [ABSTRACT FROM AUTHOR]

Citrus assamensis (Family: Rutaceae), commonly known as Satkara, is a pharmacologically diverse medicinal plant. In the present study, the leaf extracts of C. assamensis were subjected to evaluate in vitro anti-diabetic as well as in vivo anti-diarrheal, gastrointestinal motility and acute toxicity activity on Swiss albino mice by using standard protocol. Ethanol and chloroform extracts showed significant inhibitory potentials (**p<0.01) against in vitro α-amylase enzyme at the concentration of 80μg/mL. Significant (*p<0.05, **p<0.01, ***p<0.001) reduction in the number of wet feces and percentage inhibition of diarrheal activity over three hours was observed with all the test doses of the extract compared with the vehicle treated group. Both doses of methanol and ethanol extracts (*p<0.05) and chloroform extract at doses of 100 mg/kg significantly reduced the number of wet feces compared to the control. None of the extracts showed any significant in vivo acute toxicity effect on mice. [ABSTRACT FROM AUTHOR]