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Start Over Descriptor "Staphylococcal Protein A therapeutic use" Journal journal of the american veterinary medical association
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3. Plasmapheresis-immunoadsorption for treatment of systemic lupus erythematosus in a dog.

Author

Matus RE, Scott RC, Saal S, Gordon BR, and Hurvitz AI

Subjects
Animals, Cyclophosphamide therapeutic use, Dog Diseases diagnosis, Dog Diseases immunology, Dogs, Fluorescent Antibody Technique, Humans, Immunosorbent Techniques, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic immunology, Lupus Erythematosus, Systemic therapy, Male, Prednisone therapeutic use, Dog Diseases therapy, Lupus Erythematosus, Systemic veterinary, Plasmapheresis veterinary, Staphylococcal Protein A therapeutic use
Abstract

Systemic lupus erythematosus was diagnosed in a 3-year-old, male German Shepherd Dog. Clinical signs included lethargy, partial anorexia, fever, joint swelling, and skin and oral ulceration. The diagnosis was confirmed on the basis of an antinuclear antibody titer of 1:640 and immunofluorescence for immunoglobulin G at the dermal-epidermal junction in skin biopsy specimens. Treatment with prednisone and cyclophosphamide failed to induce remission. Intensive plasmapheresis-immunoadsorption, using purified Staphylococcus protein A in combination with low-dose prednisone therapy, resulted in sustained remission.

Published
1983

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