1. Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension
- Author
-
Thomas D. Giles, George Bakris, Suzanne Oparil, Michael A. Weber, Huiling Li, Madhuja Mallick, David B. Bharucha, ChunLin Chen, William G. Ferguson, John Sorin, Matthew Davis, Joesph Izzo, Nabile Andrawis, Alyn Anderson, Rogelio Bardinas-Rodriguez, Douglas Young, Andrew Schreiber, Cristian Breton, Duane Harris, Phillip LaStella, Ramon Castello, Susan Hole, Joesph Lillo, Luis Carlos Quintero, Carlos Montenegro, Jeffrey Rosen, Farid Marquez, Fredric Adler, Sady Alpizar, James Andersen, Corey Anderson, Graciela Calatayud, Kevin Cannon, Deanna Cheung, Rafel Chiong, Lisa Cohen, Harry Collins, Michael Dao, Cara H. Dawson, Donna DeSantis, Shelly Dunmyer, Sherif El-Harazi, Cecil M. Farrington, David Ferrera, Gregory S. Funk, Gregory Gottschlich, Terence T. Hart, Marvin Kalafer, Dean Kereiakes, Gigi Lefebvre, Aristolis Laliotis, Peter Mattar, Michael McCartney, Diane McConnehey, Curtis Mello, Joel Neutel, Deborah A. Burke, James Pritchard, George Raad, Bruce Rankin, John 'Chip' H. Reed, Erich Schramm, Howard Schwartz, Nathan Segall, James Shoemaker, Vakas Sial, Teresa Sligh, William Smith, Richard Stewart, Dan Streja, Danny Sugimoto, Alexander White, Hayes Williams, William Abraham, Azazuddin Ahmed, Richard Beasley, Daniel Gruener, Connie Hsu, Ryan Klein, Allen Soo, Charles P. Andrews, Clinton Corder, Donald Hurley, Elizabeth Bretton, Richard Martinez, David Morin, Miguel Trevino, Samir Arora, Curtis Scott Horn, Charles Lovell, Thomas Nussdorfer, Robert Weiss, Harold Bays, Jackson Rhudy, Edwardo Almaguer, Joseph H. Woolley, Vicki Miller, Jaynier Moya-Hechevarria, Henry Punzi, Addison Taylor, Jonathan Wilson, Arnold Alper, Patricia Buchanan, Richard Dobrusin, Alan Forker, Razmig Krumian, Samuel F. Oberstein, Andrew Lewin, Mary Bella Natividad, Armando Segui, Wayne Harper, Andrea Lawless, Lawrence S. Levinson, Shaukat Shah, Loray Blair-Britt, Patrick Carmichael, Nathaniel Winer, David Grant, Kyle Rickner, Absalom Tilley, Linda Harper, Stephen Maddock, Joseph A. Boscia, Yekaterina Khronusova, Larry D. Reed, and Chandar Abboy
- Subjects
Male ,Angiotensin receptor ,medicine.medical_specialty ,Ambulatory blood pressure ,Maximum Tolerated Dose ,Urology ,Diastole ,Risk Assessment ,Severity of Illness Index ,Plasma renin activity ,Nebivolol ,Renin-Angiotensin System ,Vasodilatory beta-blocker ,chemistry.chemical_compound ,Double-Blind Method ,Internal medicine ,Renin ,Renin–angiotensin system ,ABPM ,Internal Medicine ,Humans ,Medicine ,Aldosterone ,Dose-Response Relationship, Drug ,business.industry ,Patient Selection ,biomarkers ,Blood Pressure Monitoring, Ambulatory ,angiotensin II receptor blocker ,Treatment Outcome ,Endocrinology ,chemistry ,Valsartan ,Hypertension ,Drug Therapy, Combination ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,medicine.drug - Abstract
After demonstration of the antihypertensive efficacy of the combination of the beta-blocker nebivolol and the angiotensin receptor blocker valsartan in an 8-week, randomized, placebo-controlled trial (N = 4161), we now report the effects of this treatment on the renin-angiotensin-aldosterone system in a substudy (n = 805). Plasma renin activity increased with valsartan (54%–73%) and decreased with nebivolol (51%–65%) and the combination treatment (17%–39%). Plasma aldosterone decreased with individual treatments (valsartan, 11%–22%; nebivolol, 20%–26%), with the largest reduction (35%) observed with maximum combination dose (20 mg nebivolol/320 mg valsartan). Baseline ln(plasma renin activity) correlated with the 8-week reductions in 24-hour systolic and diastolic BP following treatments with the combination (all doses combined, P = .003 and P
- Published
- 2015