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Your search keyword '"Aadil Shaukat"' showing total 3 results
Start Over Author "Aadil Shaukat" Journal journal of the american heart association: cardiovascular and cerebrovascular disease
3 results on '"Aadil Shaukat"'

1. Coronary Artery Perforations: Glasgow Natural History Study of Covered Stent Coronary Interventions (GNOCCI) Study

Author

Thomas J. Ford, Carly Adamson, Andrew J. Morrow, Paul Rocchiccioli, Damien Collison, Peter J. McCartney, Aadil Shaukat, Mitchell Lindsay, Richard Good, Stuart Watkins, Hany Eteiba, Keith Robertson, Colin Berry, Keith G. Oldroyd, and Margaret McEntegart

Subjects
coronary artery perforation, coronary stent occlusion, covered coronary stent, outcomes, stent thrombosis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background The objective of the GNOCCI (Glasgow Natural History Study of Covered Stent Coronary Interventions) Study was to report the incidence and outcomes of coronary artery perforations over an 18‐year period at a single, high‐volume percutaneous coronary intervention center. We considered both the temporal trends and long‐term outcomes of covered stent deployment. Methods and Results We evaluated procedural and long‐term clinical outcomes following coronary perforation in a cohort of 43,343 consecutive percutaneous coronary intervention procedures. Procedural major adverse cardiac events were defined as a composite of death, myocardial infarction, stroke, target vessel revascularization, or cardiac surgery within 24 hours. A total of 161 (0.37%) procedures were complicated by coronary perforation of which 57 (35%) were Ellis grade III. Incidence increased with time over the study period (r=0.73; P

Published
2022
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2. Effects of Intracoronary Alteplase on Microvascular Function in Acute Myocardial Infarction

Author

Annette M. Maznyczka, Peter J. McCartney, Keith G. Oldroyd, Mitchell Lindsay, Margaret McEntegart, Hany Eteiba, Paul Rocchiccioli, Richard Good, Aadil Shaukat, Keith Robertson, Vivek Kodoth, John P. Greenwood, James M. Cotton, Stuart Hood, Stuart Watkins, Peter W. Macfarlane, Julie Kennedy, R. Campbell Tait, Paul Welsh, Naveed Sattar, Damien Collison, Lynsey Gillespie, Alex McConnachie, and Colin Berry

Subjects
cardiovascular magnetic resonance, fibrinolysis, microvascular obstruction, primary PCI, ST‐segment–elevation myocardial infarction, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Impaired microcirculatory reperfusion worsens prognosis following acute ST‐segment–elevation myocardial infarction. In the T‐TIME (A Trial of Low‐Dose Adjunctive Alteplase During Primary PCI) trial, microvascular obstruction on cardiovascular magnetic resonance imaging did not differ with adjunctive, low‐dose, intracoronary alteplase (10 or 20 mg) versus placebo during primary percutaneous coronary intervention. We evaluated the effects of intracoronary alteplase, during primary percutaneous coronary intervention, on the index of microcirculatory resistance, coronary flow reserve, and resistive reserve ratio. Methods and Results A prespecified physiology substudy of the T‐TIME trial. From 2016 to 2017, patients with ST‐segment–elevation myocardial infarction ≤6 hours from symptom onset were randomized in a double‐blind study to receive alteplase 20 mg, alteplase 10 mg, or placebo infused into the culprit artery postreperfusion, but prestenting. Index of microcirculatory resistance, coronary flow reserve, and resistive reserve ratio were measured after percutaneous coronary intervention. Cardiovascular magnetic resonance was performed at 2 to 7 days and 3 months. Analyses in relation to ischemic time (

Published
2020
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3. Effects of Intracoronary Alteplase on Microvascular Function in Acute Myocardial Infarction

Author

Colin Berry, Mitchell Lindsay, Stuart Watkins, Julie Kennedy, Peter W. Macfarlane, Annette Maznyczka, Damien Collison, Paul Welsh, Stuart Hood, R. Campbell Tait, James Cotton, Alex McConnachie, Keith Robertson, Paul Rocchiccioli, Hany Eteiba, Aadil Shaukat, Peter McCartney, John P Greenwood, Keith G. Oldroyd, Margaret McEntegart, Vivek Kodoth, Richard Good, Naveed Sattar, and Lynsey Gillespie

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, microvascular obstruction, primary PCI, Myocardial Infarction, 030204 cardiovascular system & hematology, Tissue plasminogen activator, Microcirculation, 03 medical and health sciences, cardiovascular magnetic resonance, 0302 clinical medicine, Percutaneous Coronary Intervention, Myocardial Fractional Flow Reserve, Double-Blind Method, Fibrinolytic Agents, St elevation myocardial infarction, Internal medicine, Fibrinolysis, medicine, Humans, Thrombolytic Therapy, 030212 general & internal medicine, Myocardial infarction, ST‐segment–elevation myocardial infarction, Prospective Studies, Prospective cohort study, Original Research, Aged, business.industry, Middle Aged, medicine.disease, Interventional Cardiology, United Kingdom, Treatment, Fractional Flow Reserve, Myocardial, Treatment Outcome, Tissue Plasminogen Activator, Cardiology, ST Elevation Myocardial Infarction, fibrinolysis, Female, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, medicine.drug
Abstract

Background Impaired microcirculatory reperfusion worsens prognosis following acute ST ‐segment–elevation myocardial infarction. In the T‐ TIME (A Trial of Low‐Dose Adjunctive Alteplase During Primary PCI) trial, microvascular obstruction on cardiovascular magnetic resonance imaging did not differ with adjunctive, low‐dose, intracoronary alteplase (10 or 20 mg) versus placebo during primary percutaneous coronary intervention. We evaluated the effects of intracoronary alteplase, during primary percutaneous coronary intervention, on the index of microcirculatory resistance, coronary flow reserve, and resistive reserve ratio. Methods and Results A prespecified physiology substudy of the T‐ TIME trial. From 2016 to 2017, patients with ST ‐segment–elevation myocardial infarction ≤6 hours from symptom onset were randomized in a double‐blind study to receive alteplase 20 mg, alteplase 10 mg, or placebo infused into the culprit artery postreperfusion, but prestenting. Index of microcirculatory resistance, coronary flow reserve, and resistive reserve ratio were measured after percutaneous coronary intervention. Cardiovascular magnetic resonance was performed at 2 to 7 days and 3 months. Analyses in relation to ischemic time (P =0.013), resistive reserve ratio ( P =0.026), and microvascular obstruction ( P =0.022), but not index of microcirculatory resistance. Conclusions In ST ‐segment–elevation myocardial infarction with ischemic time ≤6 hours, there was overall no difference in microvascular function with alteplase versus placebo. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique identifier: NCT 02257294.

Published
2020

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