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Start Over Author "Sellers, Stephanie" Journal journal of the american college of cardiology (jacc)
20 results on '"Sellers, Stephanie"'

5. TCT-69 Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration.

Author

Sellers, Stephanie, Turner, Christropher, Cartlidge, Tim, Sathananthan, Janarthanan, Sin, Frances, Bouchareb, Rihab, Mooney, John, Norgaard, Bjarne, Bax, Jeroen, Bernatchez, Pascal, Dweck, Marc, Granville, David, Newby, David, Lauck, Sandra, Webb, John, Payne, Geoffrey, Pibarot, Philippe, Blanke, Philipp, Seidman, Michael, and Leipsic, Jonathon

Subjects
*HEART valves, *AORTIC valve, *PAMPHLETS, *FIBROSIS
Published
2018
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6. TCT-96 Tricuspid Valve-in-Valve and Bioprosthetic Surgical Tricuspid and Pulmonic Valve Degeneration: Lessons From Imaging and Histopathology.

Author

Sellers, Stephanie, Cartlidge, Tim, Hensey, Mark, Turner, Christopher, Lai, Althea, Lau, Karen, Sathananthan, Janarthanan, Blanke, Philipp, Granville, David, McManus, Bruce, Webb, John, Newby, David, Dweck, Marc, and Leipsic, Jonathon

Subjects
*TRICUSPID valve, *HISTOPATHOLOGY, *TRICUSPID valve surgery, *DEGENERATION (Pathology), *HEART valves, *CONFOCAL microscopy, *TRICUSPID valve diseases
Published
2019
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7. Detection and Prediction of Bioprosthetic Aortic Valve Degeneration.

Author

Cartlidge, Timothy R.G., Doris, Mhairi K., Sellers, Stephanie L., Pawade, Tania A., White, Audrey C., Pessotto, Renzo, Kwiecinski, Jacek, Fletcher, Alison, Alcaide, Carlos, Lucatelli, Christophe, Densem, Cameron, Rudd, James H.F., van Beek, Edwin J.R., Tavares, Adriana, Virmani, Renu, Berman, Daniel, Leipsic, Jonathon A., Newby, David E., and Dweck, Marc R.

Subjects
*AORTIC valve
Abstract

Background: Bioprosthetic aortic valve degeneration is increasingly common, often unheralded, and can have catastrophic consequences.Objectives: The authors sought to assess whether 18F-fluoride positron emission tomography (PET)-computed tomography (CT) can detect bioprosthetic aortic valve degeneration and predict valve dysfunction.Methods: Explanted degenerate bioprosthetic valves were examined ex vivo. Patients with bioprosthetic aortic valves were recruited into 2 cohorts with and without prosthetic valve dysfunction and underwent in vivo contrast-enhanced CT angiography, 18F-fluoride PET, and serial echocardiography during 2 years of follow-up.Results: All ex vivo, degenerate bioprosthetic valves displayed 18F-fluoride PET uptake that colocalized with tissue degeneration on histology. In 71 patients without known bioprosthesis dysfunction, 14 had abnormal leaflet pathology on CT, and 24 demonstrated 18F-fluoride PET uptake (target-to-background ratio 1.55 [interquartile range (IQR): 1.44 to 1.88]). Patients with increased 18F-fluoride uptake exhibited more rapid deterioration in valve function compared with those without (annualized change in peak transvalvular velocity 0.30 [IQR: 0.13 to 0.61] vs. 0.01 [IQR: -0.05 to 0.16] ms-1/year; p < 0.001). Indeed 18F-fluoride uptake correlated with deterioration in all the conventional echocardiographic measures of valve function assessed (e.g., change in peak velocity, r = 0.72; p < 0.001). Each of the 10 patients who developed new overt bioprosthesis dysfunction during follow-up had evidence of 18F-fluoride uptake at baseline (target-to-background ratio 1.89 [IQR: 1.46 to 2.59]). On multivariable analysis, 18F-fluoride uptake was the only independent predictor of future bioprosthetic dysfunction.Conclusions: 18F-fluoride PET-CT identifies subclinical bioprosthetic valve degeneration, providing powerful prediction of subsequent valvular dysfunction and highlighting patients at risk of valve failure. This technique holds major promise in the diagnosis of valvular degeneration and the surveillance of patients with bioprosthetic valves. (18F-Fluoride Assessment of Aortic Bioprosthesis Durability and Outcome [18F-FAABULOUS]; NCT02304276). [ABSTRACT FROM AUTHOR]

Published
2019
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8. Late Balloon Valvuloplasty for Transcatheter Heart Valve Dysfunction.

Author

Akodad, Mariama, Blanke, Philipp, Chuang, Ming-Yu A., Duchscherer, Jade, Sellers, Stephanie L., Chatfield, Andrew G., Gulsin, Gaurav G., Lauck, Sandra, Leipsic, Jonathon A., Meier, David, Moss, Rob R., Cheung, Anson, Sathananthan, Janarthanan, Wood, David A., Ye, Jian, and Webb, John G.

Subjects
*PERCUTANEOUS balloon valvuloplasty, *HEART valves, *HEART valve prosthesis implantation, *AORTIC stenosis, *TREATMENT effectiveness, *PROSTHETIC heart valves, *CATHETERIZATION, *PROSTHESIS design & construction, AORTIC valve surgery
Abstract

Background: Transcatheter heart valve (THV) dysfunction with an elevated gradient or paravalvular leak (PVL) may be documented late after THV implantation. Medical management, paravalvular plugs, redo THV replacement, or surgical valve replacement may be considered. However, late balloon dilatation is rarely utilized because of concerns about safety or lack of efficacy.Objectives: We aimed to evaluate the safety and efficacy of late dilatation in the management of THV dysfunction.Methods: All patients who underwent late dilatation for symptomatic THV dysfunction at 2 institutions between 2016 and 2021 were identified. Baseline, procedural characteristics, and clinical and echocardiographic outcomes were documented. THV frame expansion was assessed by multislice computed tomography before and after late dilatation.Results: Late dilatation was performed in 30 patients a median of 4.6 months (IQR: 2.3-11.0 months) after THV implantation in the aortic (n = 25; 83.3%), mitral (n = 2; 6.7%), tricuspid (n = 2; 6.7%) and pulmonary (n = 1; 3.3%) position. THV underexpansion was documented at baseline, and frame expansion substantially improved after late dilatation. The mean transvalvular gradient fell in all patients. For aortic THVs specifically, mean transaortic gradient fell from 25.4 ± 13.9 mm Hg to 10.8 ± 4.1 mm Hg; P < 0.001. PVL was reduced to ≤mild in all 11 patients with a previous >mild PVL. Embolic events, stroke, annular injury, and bioprosthetic leaflet injury were not observed. Symptomatic benefit was durable at 19.6 months (IQR: 14.8-36.1 months) follow-up.Conclusions: Balloon dilatation late after THV implantation appears feasible and safe in appropriately selected patients and may result in THV frame expansion resulting in improvements in hemodynamic performance and PVL. [ABSTRACT FROM AUTHOR]

Published
2022
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9. ASSESSING THE EFFICACY OF POST-TAVR ANATOMICAL AND HEMODYNAMIC MEASUREMENTS IN PREDICTING LEAFLET THROMBOSIS USING PRE-TAVR COMPUTED TOMOGRAPHY.

Author

Venkatesh, Aniket, Esmailie, Fateme, Natarajan, Thangam, Chen, Huang, Hatoum, Hoda, Yeats, Breandan Andre Butler, Lee, Beom Jun, Gulsin, Gaurav, Tregobov, Noah, Jamieson, Colin, Sellers, Stephanie, Blanke, Philipp, Leipsic, Jonathon, Sathananthan, Janarthanan, Ruile, Philipp, Neumann, Franz-Josef, Thourani, Vinod H., and Dasi, Lakshmi Prasad

Subjects
*HEMODYNAMICS, *THROMBOSIS, *FORECASTING, *MEASUREMENT
Published
2024
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13. TCT-519 Timing of Bioprosthetic Valve Fracture in Transcatheter Valve-in-Valve Intervention: Impact on Valve Durability and Leaflet Integrity.

Author

Meier, David, Payne, Geoffrey, Mostaço-Guidolin, Leila, Bouchareb, Rihab, Rich, Courtney, Lai, Althea, Chatfield, Andrew, Akodad, Mariama, Salcudean, Hannah, Puehler, Thomas, Pibarot, Philippe, Allen, Keith, Chhatriwalla, Adnan, Sondergaard, Lars, Wood, David, Webb, John, Leipsic, Jonathon, Sathananthan, Janarthanan, and Sellers, Stephanie

Subjects
*BIOPROSTHETIC heart valves, *DURABILITY, *PAMPHLETS
Published
2022
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18. TCT-33 Bioprosthetic Valve Fracture Performed Pre– Versus Post–Valve-in-Valve Transcatheter Aortic Valve Replacement: Insights From Bench Testing.

Author

Sathananthan, Janarthanan, Fraser, Rob, Hatoum, Hoda, Barlow, Aaron, Stanová, Viktória, Hensey, Mark, Landes, Uri, Alkhodair, Abdullah, Sellers, Stephanie, Cheung, Anson, Ye, Jian, Allen, Keith, Chhatriwalla, Adnan, Blanke, Philipp, Rieu, Régis, Pibarot, Philippe, Dasi, Lakshmi, Leipsic, Jonathon, Wood, David, and Webb, John

Subjects
*HEART valve prosthesis implantation, *VALVES
Published
2019
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20. SMOKING AND ITS RELATIONSHIP WITH LONG TERM EVENTS: FURTHER INSIGHTS FROM THE CONFIRM (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER) REGISTRY.

Author

Omid-Fard, Nima, Ahmadi, Amir, Blanke, Philipp, Sellers, Stephanie, Gransar, Heidi, Berman, Daniel, Callister, Tracy, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Budoff, Matthew, Kaufmann, Philipp, Raff, Gilbert, Chinnaiyan, Kavitha, Villines, Todd, Feuchtner, Gudrun, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, and Rubinshtein, Ronen

Subjects
*CORONARY angiography, *INSIGHT, *TERMS & phrases
Published
2017
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