1. Trends in Transcatheter and Surgical Aortic Valve Replacement Among Older Adults in the United States.
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Mori, Makoto, Gupta, Aakriti, Wang, Yun, Vahl, Torsten, Nazif, Tamim, Kirtane, Ajay J., George, Isaac, Yong, Celina M., Onuma, Oyere, Kodali, Susheel, Geirsson, Arnar, Leon, Martin B., and Krumholz, Harlan M.
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HEART valve prosthesis implantation , *OLDER people , *AORTIC valve transplantation , *PROPORTIONAL hazards models , *TREATMENT effectiveness - Abstract
Background: Recent trends, including survival beyond 30 days, in aortic valve replacement (AVR) following the expansion of indications for transcatheter aortic valve replacement (TAVR) are not well-understood.Objectives: The authors sought to characterize the trends in characteristics and outcomes of patients undergoing AVR.Methods: The authors analyzed Medicare beneficiaries who underwent TAVR and SAVR in 2012 to 2019. They evaluated case volume, demographics, comorbidities, 1-year mortality, and discharge disposition. Cox proportional hazard models were used to assess the annual change in outcomes.Results: Per 100,000 beneficiary-years, AVR increased from 107 to 156, TAVR increased from 19 to 101, whereas SAVR declined from 88 to 54. The median [interquartile range] age remained similar from 77 [71-83] years to 78 [72-84] years for overall AVR, decreased from 84 [79-88] years to 81 [75-86] years for TAVR, and decreased from 76 [71-81] years to 72 [68-77] years for SAVR. For all AVR patients, the prevalence of comorbidities remained relatively stable. The 1-year mortality for all AVR decreased from 11.9% to 9.4%. Annual change in the adjusted odds of 1-year mortality was 0.93 (95% CI: 0.92-0.94) for TAVR and 0.98 (95% CI: 0.97-0.99) for SAVR, and 0.94 (95% CI: 0.93-0.95) for all AVR. Patients discharged to home after AVR increased from 24.2% to 54.7%, primarily driven by increasing home discharge after TAVR.Conclusions: The advent of TAVR has led to about a 60% increase in overall AVR in older adults. Improving outcomes in AVR as a whole following the advent of TAVR with increased access is a reassuring trend. [ABSTRACT FROM AUTHOR]- Published
- 2021
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