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Start Over Author "Seliger, Stephen" Journal journal of the american college of cardiology
33 results on '"Seliger, Stephen"'

3. BASELINE CARDIAC TROPONIN T, CLINICAL OUTCOMES AND VERICIGUAT TREATMENT EFFECT IN HEART FAILURE WITH REDUCED EJECTION FRACTION STUDY: INSIGHTS FROM THE VICTORIA TRIAL

Author

DeFilippi, Christopher R., primary, Alemayehu, Wendimagegn, additional, Voors, Adriaan, additional, Kaye, David, additional, Anstrom, Kevin, additional, Butler, Javed, additional, Ezekowitz, Justin, additional, Hernandez, Adrian, additional, Koglin, Joerg, additional, Lam, Carolyn, additional, Pieske, Burkert, additional, Ponikowski, Piotr, additional, Roessig, Lothar, additional, Seliger, Stephen, additional, Westerhout, Cynthia, additional, Armstrong, Paul, additional, and O’Connor, Christopher, additional

Published
2021
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9. MYOCARDIAL MICRO-INJURY IS ASSOCIATED WITH IMPAIRED LV SYSTOLIC AND DIASTOLIC FUNCTION IN OLDER COMMUNITY-BASED INDIVIDUALS WITHOUT CARDIOVASCULAR DISEASE - ASSESSMENT BY SPECKLE TRACKING ECHOCARDIOGRAPHIC MEASUREMENT OF LV AND LA STRAIN: THE CARDIOVASCULAR HEALTH STUDY (CHS)

Author

Gottdiener, John S., primary, Seliger, Stephen, additional, DeFilippi, Christopher, additional, Christenson, Robert, additional, Kizer, Jorge, additional, Psaty, Bruce, additional, and Shah, Sanjiv, additional

Published
2019
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10. ACCURACY OF THE POOLED COHORT EQUATION TO ESTIMATE ATHEROSCLEROTIC CARDIOVASCULAR DISEASE EVENTS BY OBESITY CLASS: A POOLED ASSESSMENT OF FIVE LONGITUDINAL COHORT STUDIES

Author

Khera, Rohan, primary, Pandey, Ambarish, additional, Ayers, Colby, additional, Carnethon, Mercedes, additional, Greenland, Philip, additional, Nambi, Vijay, additional, Seliger, Stephen, additional, Chaves, Paulo, additional, Lloyd-Jones, Donald, additional, Berry, Jarett, additional, de Lemos, James, additional, and Neeland, Ian, additional

Published
2018
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16. Age- and Sex-Dependent Upper Reference Limits for the High-Sensitivity Cardiac Troponin T Assay

Author

Gore, M. Odette, primary, Seliger, Stephen L., additional, deFilippi, Christopher R., additional, Nambi, Vijay, additional, Christenson, Robert H., additional, Hashim, Ibrahim A., additional, Hoogeveen, Ron C., additional, Ayers, Colby R., additional, Sun, Wensheng, additional, McGuire, Darren K., additional, Ballantyne, Christie M., additional, and de Lemos, James A., additional

Published
2014
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21. Biomarkers of Chronic Cardiac Injury and Hemodynamic Stress Identify a Malignant Phenotype of Left Ventricular Hypertrophy in the General Population

Author

Neeland, Ian J., primary, Drazner, Mark H., additional, Berry, Jarett D., additional, Ayers, Colby R., additional, deFilippi, Christopher, additional, Seliger, Stephen L., additional, Nambi, Vijay, additional, McGuire, Darren K., additional, Omland, Torbjørn, additional, and de Lemos, James A., additional

Published
2013
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23. ECHOCARDIOGRAPHIC AND BIOMARKER PHENOTYPE OF HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF) IN OLDER INDIVIDUALS IN COMPARISON TO HYPERTENSION WITHOUT HEART FAILURE (HTN), ELDERLY WITH RISK FACTORS, AND HEALTHY AGING. IMPORTANCE OF MYOCYTE INJURY, FIBROSIS, LV HYPERTROPHY, AND DIASTOLIC LOAD

Author

Gottdiener, John S., primary, Bartz, Traci, additional, DeFilippi, Christopher, additional, Kop, Willem, additional, Kitzman, Dalane, additional, Barasch, Eddy, additional, Seliger, Stephen, additional, and Lloyd-Jones, Donald, additional

Published
2012
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31. Left Ventricular Ejection Fraction Assessment in Older Adults An Adjunct to Natriuretic Peptide Testing to Identify Risk of New-Onset Heart Failure and Cardiovascular Death?

Author

deFilippi, Christopher R., Christenson, Robert H., Kop, Willem J., Gottdiener, John S., Zhan, Min, and Seliger, Stephen L.

Subjects
echocardiography, heart failure, cardiovascular diseases, natriuretic peptides, outcomes, elderly, hormones, hormone substitutes, and hormone antagonists
Abstract

ObjectivesThe goal of this paper was to determine whether assessment of left ventricular ejection fraction (LVEF) enhances prediction of new-onset heart failure (HF) and cardiovascular mortality over and above N-terminal pro–B-type natriuretic peptide (NT-proBNP) level in older adults.BackgroundElevated NT-proBNP levels are common in older adults and are associated with increased risk of HF.MethodsNT-proBNP and LVEF were measured in 4,137 older adults free of HF. Repeat measures of NT-proBNP were performed 2 to 3 years later and echocardiography was repeated 5 years later (n = 2,375), with a median follow-up of 10.7 years. The addition of an abnormal (

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32. Dynamic Cardiovascular Risk Assessment in Elderly People The Role of Repeated N-Terminal Pro–B-Type Natriuretic Peptide Testing

Author

deFilippi, Christopher R., Christenson, Robert H., Gottdiener, John S., Kop, Willem J., and Seliger, Stephen L.

Subjects
biomarkers, heart failure, risk stratification, elderly
Abstract

ObjectivesThis study sought to determine whether serial measurement of N-terminal pro–B-type natriuretic peptide (NT-proBNP) in community-dwelling elderly people would provide additional prognostic information to that from traditional risk factors.BackgroundAccurate cardiovascular risk stratification is challenging in elderly people.MethodsNT-proBNP was measured at baseline and 2 to 3 years later in 2,975 community-dwelling older adults free of heart failure in the longitudinal CHS (Cardiovascular Health Study). This investigation examined the risk of new-onset heart failure (HF) and death from cardiovascular causes associated with baseline NT-proBNP and changes in NT-proBNP levels, adjusting for potential confounders.ResultsNT-proBNP levels in the highest quintile (>267.7 pg/ml) were independently associated with greater risks of HF (hazard ratio [HR]: 3.05; 95% confidence interval [CI]: 2.46 to 3.78) and cardiovascular death (HR: 3.02; 95% CI: 2.36 to 3.86) compared with the lowest quintile (25% increase on follow-up to >190 pg/ml (21%) were at greater adjusted risk of HF (HR: 2.13; 95% CI: 1.68 to 2.71) and cardiovascular death (HR: 1.91; 95% CI: 1.43 to 2.53) compared with those with sustained low levels. Among participants with initially high NT-proBNP, those who developed a >25% increase (40%) were at higher risk of HF (HR: 2.06; 95% CI: 1.56 to 2.72) and cardiovascular death (HR: 1.88; 95% CI: 1.37 to 2.57), whereas those who developed a >25% decrease to ≤190 pg/ml (15%) were at lower risk of HF (HR: 0.58; 95% CI: 0.36 to 0.93) and cardiovascular death (HR: 0.57; 95% CI: 0.32 to 1.01) compared with those with unchanged high values.ConclusionsNT-proBNP levels independently predict heart failure and cardiovascular death in older adults. NT-proBNP levels frequently change over time, and these fluctuations reflect dynamic changes in cardiovascular risk.

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