1. Immediate results and one-year clinical outcome after percutaneous coronary interventions in chronic total occlusions
- Author
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Gabriele Gabrielli, Carlo Di Mario, Paolo Rubartelli, Luigi Salemme, Federica Ettori, Federico Piscione, Corinna Giachero, Toast-Gise Investigators, Francesco Bedogni, Alessandro Fontanelli, Zoran Olivari, and Leonardo Spedicato
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,medicine.disease ,Surgery ,Coronary artery bypass surgery ,Angioplasty ,Conventional PCI ,medicine ,cardiovascular diseases ,Myocardial infarction ,Myocardial infarction diagnosis ,business ,Cardiology and Cardiovascular Medicine ,TIMI ,Mace - Abstract
Objectives We sought to investigate the success rate and the acute and 12-month clinical outcome of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in the contemporary era. Background The technique of PCI involving CTO has improved over time. However, limited data on acute and follow-up results in patients treated with PCI on CTO in recent years are available. Methods Four hundred nineteen consecutive patients scheduled for PCI of CTO of ≥30 days of duration were enrolled in 29 centers; 390 CTOs were confirmed in 376 patients in an independent core laboratory. The end points were technical and procedural success, in-hospital and 12-month major adverse cardiac events (MACE) occurrence, and 12-month symptomatic status. Results Technical and procedural success was obtained in 77.2% and 73.3% of lesions, respectively. In-hospital major adverse cardiac events occurred in 5.1% of patients. Multivariate analysis identified CTO length >15 mm or not measurable, moderate to severe calcifications, duration ≥180 days, and multivessel disease as significant predictors of PCI failure. At 12 months, patients with a successful procedure experienced a lower incidence of cardiac deaths or myocardial infarction (1.05% vs. 7.23%, p = 0.005), a reduced need for coronary artery bypass surgery (2.45% vs. 15.7%, p Conclusions Successful PCI was achieved in a high percentage of CTOs with a low incidence of complications. At one-year follow-up, patients with successful PCI of a CTO had a significantly better clinical outcome than those whose PCI was unsuccessful.
- Published
- 2003
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