Search

ObjectivesThe aim of this retrospective study was to determine the predictors of diffuse in-stent restenosis (ISR) among the lesions causing the first ISR by intravascular ultrasound (IVUS) studies.BackgroundAlthough some predictors of diffuse ISR have been reported, parameters on IVUS relating to diffuse ISR are not well characterized.MethodsWe classified 52 ISR lesions that had undergone successful stent implantation and led to restenosis into two types—focal and diffuse ISR—using quantitative coronary angiography. Restenosis was defined as ≥50% diameter stenosis, and diffuse ISR as lesion length ≥10 mm at follow-up. The remodeling index (RI) was defined as the vessel area at the target lesion divided by that of averaged reference segments.ResultsThere were no significant differences in patient, angiographic, and procedural characteristics between the focal (n = 25) and diffuse (n = 27) ISR groups. Baseline RI was significantly greater in the diffuse ISR group (1.03 ± 0.18 vs. 0.88 ± 0.24, p = 0.0159). Negative remodeling, defined as RI