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Background The impact of left atrial appendage (LAA) exclusion, comparing an epicardial LAA or an endocardial LAA device, on systemic homeostasis remains unknown. Objectives This study compared the effects of epicardial or endocardial LAA devices on the neurohormonal profiles of patients, emphasizing the roles of the renin-angiotensin-aldosterone system and the autonomic nervous system. Methods This is a prospective, single-center, observational study including 77 patients who underwent LAA closure by an epicardial (n = 38) or endocardial (n = 39) device. Key hormones involved in the adrenergic system (adrenaline, noradrenaline), renin-angiotensin-aldosterone system (aldosterone, renin), metabolic system (adiponectin, free fatty acids, insulin, β-hydroxybutyrate, and free glycerols), and natriuresis (atrial and B-type natriuretic peptides) were assessed immediately before the procedure, immediately after device deployment, at 24 h, and at 3 months follow-up. Results In the epicardial LAA device group, when compared with baseline blood adrenaline, noradrenaline and aldosterone were significantly lower at 24 h and 3 months (p Conclusions There are substantial differences in hemodynamics and neurohormonal effects of LAA exclusion with epicardial and endocardial devices. Further studies are required to elucidate the underlying mechanism of these physiological changes.

Outpatient rhythm monitoring with implantable loop recorders (ILR) to assess atrial fibrillation (AF) is increasingly used in cryptogenic stroke (CS). Because risk of stroke is variable based on duration of AF, patterns of AF detected on ILR may have implications for anticoagulation. All patients

LP extractions is a relatively new field with limited operator experience. We compared the Nanostim (NS) vs Micra transcatheter (MT) LP. Pertinent details of retrieval such as indication, days post implantation, complications and post procedure device management was obtained from the database

Randomized controlled trials (RCTs) of bone marrow cell (BMC) therapy in patients with ischemic heart disease (IHD) have yielded variable results. This discrepancy has been partially attributed to the utilization of dissimilar cardiac imaging modalities. Magnetic resonance imagining (MRI) assessment

Randomized controlled trials (RCTs) evaluating the efficacy of bone marrow cells (BMCs) in patients with acute myocardial infarction (AMI) have yielded discordant results. These discrepant results may potentially be attributed to use of different cardiac imaging techniques. Most studies have

Recent studies have shown that prolonged rhythm monitoring results in increased detection of atrial fibrillation (AF) in patients with cryptogenic stroke (CS). We performed a systematic review and meta-analysis of all the randomized control trials (RCTs) that used prolonged rhythm monitoring

To evaluate the impact of pre-procedural oral prednisone on inflammatory cytokines (TNF-α, Interleukin (IL)-1, IL-6, and IL-8) levels and outcomes of atrial fibrillation (AF) ablation in patients with paroxysmal AF. A total of 60 patients with paroxysmal AF undergoing AF ablation were randomized (

Incidental findings (IF) are commonly seen in pre-procedural cardiac CT scan obtained prior to Atrial Fibrillation (AF) ablation. We intended to evaluate the prevalence and significance of these IF in otherwise healthy patient undergoing AF ablation. We performed a retrospective observational study

The limited data regarding epicardial ligation of left atrial appendage (LAA) has discordant results regarding the safety. To delineate the safety and efficacy of LAA closure with the LARIAT device for LAA ligation. This is a retrospective, multicenter registry of 712 consecutive patients (mean

Left atrial appendage (LAA) a major source of ANP (atrial natriuretic peptide) which can influence the endocrine axis. The physiologic effects of LAA exclusion on systemic homeostasis have not been previously studied. 37 consecutive patients (7 women (19%)/30 men (81%); age 71±8; CHAD2 2.6±1.1

Arteriovenous (AV) malformations cause significant lower gasterointestinal bleeds in patients who are on oral anticoagulation for atrial fibrillation or deep venous thrombosis. This complicates the continued care of these patients and put them at significant risk for recurrent bleeds, anemia forcing