375 results on '"Eric D. Peterson"'
Search Results
2. TRENDS OF BLOOD GLUCOSE CONTROL IN THE US DURING THE COVID-19 PANDEMIC: RESULTS IN 449,805 PERSONS WITH DIABETES MELLITUS
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Nishant Shah, Apurva Khedagi, Robert M. Clare, Karen E. Chiswell, Ann Marie Navar, Bimal R. Shah, and Eric D. Peterson
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Cardiology and Cardiovascular Medicine - Published
- 2023
3. Should Cardiovascular Preventive Therapy Be Over-the-Counter?
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Neha J. Pagidipati and Eric D. Peterson
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Preventive therapy ,medicine.medical_specialty ,business.industry ,medicine ,Humans ,Nonprescription Drugs ,Over-the-counter ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business ,Cardiovascular System - Published
- 2021
4. Gerotechnology for Older Adults With Cardiovascular Diseases
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Deborah S Croy, Michael P. Dorsch, Ruth M. Masterson Creber, John A. Batsis, Michael W. Rich, Karen P. Alexander, Craig J. Beavers, Nicole M. Orr, Mathew S. Maurer, Nanette K. Wenger, Ashok Krishnaswami, Spyros Kitsiou, Gwen M. Bernacki, Sanjeev P. Bhavnani, Eric D. Peterson, Mintu P. Turakhia, James N. Kirkpatrick, John A. Dodson, Andrew M. Freeman, Parag Goyal, and Daniel E. Forman
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Gerontology ,Telemedicine ,education.field_of_study ,Palliative care ,business.industry ,Visual impairment ,Population ,Telehealth ,Disease ,030204 cardiovascular system & hematology ,Digital health ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,medicine.symptom ,Disease management (health) ,Cardiology and Cardiovascular Medicine ,business ,education - Abstract
The growing population of older adults (age ≥65 years) is expected to lead to higher rates of cardiovascular disease. The expansion of digital health (encompassing telehealth, telemedicine, mobile health, and remote patient monitoring), Internet access, and cellular technologies provides an opportunity to enhance patient care and improve health outcomes—opportunities that are particularly relevant during the current coronavirus disease-2019 pandemic. Insufficient dexterity, visual impairment, and cognitive dysfunction, found commonly in older adults should be taken into consideration in the development and utilization of existing technologies. If not implemented strategically and appropriately, these can lead to inequities propagating digital divides among older adults, across disease severities and socioeconomic distributions. A systematic approach, therefore, is needed to study and implement digital health strategies in older adults. This review will focus on current knowledge of the benefits, barriers, and use of digital health in older adults for cardiovascular disease management.
- Published
- 2020
5. Guidelines for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: JACC Guideline Comparison
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Michelle D, Kelsey, Adam J, Nelson, Jennifer B, Green, Christopher B, Granger, Eric D, Peterson, Darren K, McGuire, and Neha J, Pagidipati
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Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Humans ,Hypoglycemic Agents ,Cholesterol, LDL ,Sodium-Glucose Transporter 2 Inhibitors ,United States - Abstract
Cardiovascular disease is a leading cause of morbidity and mortality in individuals with type 2 diabetes mellitus. These high-risk patients benefit from aggressive risk factor management, with blood pressure and low-density lipoprotein-cholesterol treatment, glycemic control, kidney protection, and lifestyle intervention. There are several recommendation and guideline documents across cardiology, endocrinology, nephrology, and general medicine professional societies from the United States and Europe with recommendations for cardiovascular risk reduction in patients with type 2 diabetes mellitus. Although there are some noteworthy differences, particularly in risk stratification, low-density lipoprotein-cholesterol and blood pressure treatment targets, and the use of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, overall there is considerable alignment across recommendations from different professional societies.
- Published
- 2022
6. Cardiovascular Biomarkers and Imaging in Older Adults
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Radmila Lyubarova, David B. Reuben, Michael W. Rich, Susan J. Zieman, Daniel E. Forman, James A. de Lemos, Eric D. Peterson, Marcel E. Salive, John A. Spertus, and Leslee J. Shaw
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Gerontology ,Geriatrics ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Cardiovascular biomarkers ,Population ,Diagnostic test ,Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Younger adults ,Multidisciplinary approach ,medicine ,Biomarker (medicine) ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,education - Abstract
Whereas the burgeoning population of older adults is intrinsically vulnerable to cardiovascular disease, the utility of many management precepts that were validated in younger adults is often unclear. Whereas biomarker- and imaging-based tests are a major part of cardiovascular disease care, basic assumptions about their use and efficacy cannot be simply extrapolated to many older adults. Biology, physiology, and body composition change with aging, with important influences on cardiovascular disease testing procedures and their interpretation. Furthermore, clinical priorities of older adults are more heterogeneous, potentially undercutting the utility of testing data that are collected. The American College of Cardiology and the National Institutes on Aging, in collaboration with the American Geriatrics Society, convened, at the American College of Cardiology Heart House, a 2-day multidisciplinary workshop, "Diagnostic Testing in Older Adults with Cardiovascular Disease," to address these issues. This review summarizes key concepts, clinical limitations, and important opportunities for research.
- Published
- 2020
7. Oral Anticoagulation and Cardiovascular Outcomes in Patients With Atrial Fibrillation and End-Stage Renal Disease
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Eric Black-Maier, Eric D. Peterson, Sean D. Pokorney, Christopher B. Granger, Daniel J. Friedman, Laine Thomas, Jonathan P. Piccini, Sreekanth Vemulapalli, and Anne S. Hellkamp
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Male ,medicine.medical_specialty ,Administration, Oral ,030204 cardiovascular system & hematology ,End stage renal disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,030212 general & internal medicine ,Stroke ,Aged ,Retrospective Studies ,Proportional hazards model ,business.industry ,Hazard ratio ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Confidence interval ,Treatment Outcome ,Cohort ,Propensity score matching ,Kidney Failure, Chronic ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Atrial fibrillation (AF) is common in patients with end-stage renal disease (ESRD). The impact of oral anticoagulation (OAC) in ESRD patients is uncertain. Objectives The purpose of this study was to describe patterns of OAC use in ESRD patients with AF and their associations with cardiovascular outcomes. Methods Using Medicare fee-for-service 5% claims data from 2007 to 2013, we analyzed treatment and outcomes in a cohort of patients with ESRD and AF. Prescription drug benefit information was used to determine the timing of OAC therapy. Cox proportional hazards modeling was used to compare outcomes including death, all-cause stroke, ischemic stroke, hemorrhagic stroke, and bleeding hospitalizations in ESRD patients treated with or without OAC. Results The cohort included 8,410 patients with AF and ESRD. A total of 3,043 (36.2%) patients were treated with OAC at some time during the study period. Propensity scores used to match 1,519 patients with AF and ESRD on OAC with 3,018 ESRD patients without OAC. Treatment with OAC was not associated with hospitalization for stroke (hazard ratio [HR]: 1.00; 95% confidence interval [CI]: 0.23 to 1.35; p = 0.97) or death (HR: 1.02; 95% CI: 0.94 to 1.10; p = 0.62). OAC was associated with an increased risk of hospitalization for bleeding (HR: 1.26; 95% CI: 1.09 to 1.46; p = 0.0017) and intracranial hemorrhage (HR: 1.30; 95% CI: 1.07 to 1.59; p = 0.0094). Conclusions OAC utilization was low in patients with AF and ESRD. We found no association between OAC use and reduced risk of stroke or death. OAC use was associated with increased risks of hospitalization for bleeding or intracranial hemorrhage. Alternative stroke prevention strategies are needed in patients with ESRD and AF.
- Published
- 2020
8. Risk-Adjusted, 30-Day Home Time After Transcatheter Aortic Valve Replacement as a Hospital-Level Performance Metric
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Amgad Mentias, Neil Keshvani, Milind Y. Desai, Dharam J. Kumbhani, Mary Vaughan Sarrazin, Yubo Gao, Samir Kapadia, Eric D. Peterson, Michael Mack, Saket Girotra, and Ambarish Pandey
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Aged, 80 and over ,Male ,Hospitals, Low-Volume ,Aortic Valve Stenosis ,Long-Term Care ,Patient Readmission ,United States ,Hospitalization ,Transcatheter Aortic Valve Replacement ,Humans ,Female ,Risk Adjustment ,Mortality ,Cardiology and Cardiovascular Medicine ,Hospitals, Teaching ,Hospitals, High-Volume ,Quality Indicators, Health Care ,Skilled Nursing Facilities - Abstract
Patient-centric measures of hospital performance for transcatheter aortic valve replacement (TAVR) are needed.This study evaluated 30-day, risk-adjusted home time as a hospital performance metric for patients who underwent TAVR.This study identified 160,792 Medicare beneficiaries who underwent elective TAVR from 2015 to 2019. Home time was calculated for each patient as the number of days alive and spent outside the hospital, skilled nursing facility (SNF), and long-term acute care facility for 30 days after the TAVR procedure date. Correlations between risk-adjusted, 30-day home time and other metrics (30-day, risk-adjusted readmission rate [RSRR], 30-day, risk-adjusted mortality rate [RSMR], and annual TAVR volume) were estimated using Pearson's correlation. Meaningful upward or downward reclassification (≥2 quartile ranks) in hospital performance based on quartiles of risk-adjusted, 30-day home time compared with quartiles of other measures were assessed.Median risk-adjusted, 30-day home time was 27.4 days (interquartile range [IQR]: 26.3-28.5 days). The largest proportion of days lost from 30-day home time was hospital stay after TAVR and SNF stay. An inverse correlation was observed between hospital-level, risk-adjusted, 30-day home time and 30-day RSRR (r = -0.465; P 0.001) and 30-day RSMR (r = -0.3996; P 0.001). The use of the 30-day, risk-adjusted home time was associated with reclassification in hospital performance rank hospitals compared with other metrics (9.1% up-classified, 11.2% down-classified vs RSRR; 9.1% up-classified, 10.3% down-classified vs RSMR; and 20.1% up-classified, 19.3% down-classified vs annual TAVR volume).Risk-adjusted, 30-day home time represents a novel patient-centered performance metric for TAVR hospitals that may provide a complimentary assessment to currently used metrics.
- Published
- 2021
9. Trajectories of Non–HDL Cholesterol Across Midlife
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John T. Wilkins, Michael J. Pencina, Karol M. Pencina, Allan D. Sniderman, Ramachandran S. Vasan, Ann Marie Navar, George Thanassoulis, and Eric D. Peterson
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medicine.medical_specialty ,Framingham Risk Score ,Offspring ,business.industry ,Disease ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Cardiovascular prevention ,Internal medicine ,Diabetes mellitus ,Non hdl cholesterol ,Medicine ,Life course approach ,lipids (amino acids, peptides, and proteins) ,030212 general & internal medicine ,Young adult ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Extended elevations of non–high-density lipoprotein cholesterol (non–HDL-C) across a lifespan are associated with increased risk of cardiovascular disease (CVD). However, optimal testing intervals to identify individuals with high lipid-related CVD risk are unknown. Objectives This study determined the extent to which lipid levels in young adulthood predict future lipid trajectories and associated long-term CVD risk. Methods A sample of 2,516 Framingham Offspring study participants 25 to 40 years of age free of CVD and diabetes had their non–HDL-C progression modeled over 8 study examinations (mean follow-up 32.6 years) using group-based methods. CVD risk based on 25 to 30 years of follow-up was evaluated using Kaplan-Meier analyses for those with mean non–HDL-C ≥160 mg/dl (“high”) and Results The trajectories of the lipid levels were generally stable over the 30-year life course; mean non–HDL-C measured in young adulthood were highly predictive of levels later in life. Individuals could be reliably assigned to high and low non–HDL-C groups based on 2 measurements collected between 25 to 40 years of age. Overall, 80% of those with non–HDL-C ≥160 mg/dl at the first 2 exams remained in the high group on subsequent 25-year testing, whereas 88% of those with non–HDL-C Conclusions Most adults with elevated non–HDL-C early in life continue to have high non–HDL-C over their life course, leading to significantly increased risk of CVD. The results demonstrate that early lipid monitoring before 40 years of age would identify a majority of those with a high likelihood for lifetime elevated lipid levels who also have a high long-term risk for CVD. This information could facilitate informed patient–provider discussion about the potential benefits of preventive lipid-lowering efforts during the early midlife period.
- Published
- 2019
10. Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease
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Alan Zajarias, Eric D. Peterson, E. Murat Tuzcu, Dadi Dai, Ralph G. Brindis, John D. Carroll, Frederick L. Grover, Fred H. Edwards, Michael J. Mack, Mohanad Hamandi, Brian R. Lindman, Molly Szerlip, Sean M. O'Brien, Vinod H. Thourani, Sreekanth Vemalapalli, Matthew Brennan, Dave Shahian, Hersh S. Maniar, John S. Rumsfeld, and David R. Holmes
- Subjects
Male ,Risk ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Comorbidity ,Disease ,030204 cardiovascular system & hematology ,End stage renal disease ,Transcatheter Aortic Valve Replacement ,03 medical and health sciences ,0302 clinical medicine ,Valve replacement ,Aortic valve replacement ,Reference Values ,Renal Dialysis ,Humans ,Medicine ,In patient ,Hospital Mortality ,Registries ,030212 general & internal medicine ,education ,Dialysis ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Aortic Valve Stenosis ,medicine.disease ,Surgery ,Stenosis ,Treatment Outcome ,Kidney Failure, Chronic ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
In patients with end-stage renal disease (ESRD), surgical aortic valve replacement is associated with higher early and late mortality, and adverse outcomes compared with patients without renal disease. Transcatheter aortic valve replacement (TAVR) offers another alternative, but there are limited reported outcomes.The purpose of this study was to determine the outcomes of TAVR in patients with ESRD.Among the first 72,631 patients with severe aortic stenosis (AS) treated with TAVR enrolled in the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) TVT (Transcatheter Valve Therapies) registry, 3,053 (4.2%) patients had ESRD and were compared with patients who were not on dialysis for demographics, risk factors, and outcomes.Compared with the nondialysis patients, ESRD patients were younger (76 years vs. 83 years; p 0.01) and had higher rates of comorbidities leading to a higher STS predicted risk of mortality (median 13.5% vs. 6.2%; p 0.01). ESRD patients had a higher in-hospital mortality (5.1% vs. 3.4%; p 0.01), although the observed to expected ratio was lower (0.32 vs. 0.44; p 0.01). ESRD patients also had a similar rate of major vascular complications (4.5% vs. 4.6%; p = 0.86), but a higher rate of major bleeding (1.4% vs. 1.0%; p = 0.03). The 1-year mortality was significantly higher in dialysis patients (36.8% vs. 18.7%; p 0.01).Patients undergoing TAVR with ESRD are at higher risk and had higher in-hospital mortality and bleeding, but similar vascular complications, when compared with those who are not dialysis dependent. The 1-year survival raises concerns regarding diminished benefit in this population. TAVR should be used judiciously after full discussion of the risk-benefit ratio in patients on dialysis.
- Published
- 2019
11. TRENDS IN UPTAKE AND HOSPITAL-LEVEL VARIABILITY OF DIRECT ORAL ANTICOAGULANTS FOR PATIENTS WITH ATRIAL FIBRILLATION: A NATIONWIDE ANALYSIS OF 432,536 PATIENTS
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Ahmed A. Kolkailah, Ann Marie Navar, Robert Overton, Nishant Shah, Justin Rousseau, Greg C. Flaker, Michael Pignone, and Eric D. Peterson
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
12. GAPS IN GUIDELINE-BASED LIPID-LOWERING THERAPY FOR SECONDARY PREVENTION IN THE UNITED STATES: A NATIONWIDE ANALYSIS OF 227,824 PATIENTS
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Ahmed A. Kolkailah, Eric D. Peterson, Anand Gupta, Tasha Marie Boshears, Ethan Schneider, Yiqing Wang, Kristin Gillard, Marc Israel, and Ann Marie Navar
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Cardiology and Cardiovascular Medicine - Published
- 2022
13. COMPARING VOLUME VERSUS QUALITY THRESHOLDS ON OUTCOMES AND ACCESS TO TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR) IN THE UNITED STATES: INSIGHTS FROM THE TVT REGISTRY
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Adam J. Nelson, Zachary Wegermann, Dianne Gallup, Sean O’Brien, Andrzej Kosinski, Vinod H. Thourani, Dharam J. Kumbhani, Ajay J. Kirtane, Joe Allen, John D. Carroll, David M. Shahian, Nimesh Desai, Ralph G. Brindis, Eric D. Peterson, David Cohen, and Sreekanth Vemulapalli
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Cardiology and Cardiovascular Medicine - Published
- 2022
14. CORRELATION BETWEEN HOSPITAL PROCEDURAL VOLUMES AND OUTCOMES FOR TAVR AND MTEER IN THE UNITED STATES: A STS/ACC TVT REGISTRY ANALYSIS
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Dharam J. Kumbhani, Pratik Manandhar, Anthony A. Bavry, Adnan Chhatriwalla, Jay S. Giri, Michael J. Mack, John D. Carroll, Ambarish Pandey, Andrzej Kosinski, Eric D. Peterson, Tsuyoshi Kaneko, James A. de Lemos, and Sreekanth Vemulapalli
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Cardiology and Cardiovascular Medicine - Published
- 2022
15. Gerotechnology for Older Adults With Cardiovascular Diseases: JACC State-of-the-Art Review
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Ashok, Krishnaswami, Craig, Beavers, Michael P, Dorsch, John A, Dodson, Ruth, Masterson Creber, Spyros, Kitsiou, Parag, Goyal, Mathew S, Maurer, Nanette K, Wenger, Deborah S, Croy, Karen P, Alexander, John A, Batsis, Mintu P, Turakhia, Daniel E, Forman, Gwen M, Bernacki, James N, Kirkpatrick, Nicole M, Orr, Eric D, Peterson, Michael W, Rich, Andrew M, Freeman, and Sanjeev P, Bhavnani
- Subjects
Clinical Trials as Topic ,Population Dynamics ,COVID-19 ,Long-Term Care ,Telemedicine ,Wearable Electronic Devices ,Cardiovascular Diseases ,Geriatrics ,Humans ,Smartphone ,Pandemics ,Subacute Care ,Aged ,Internet Access - Abstract
The growing population of older adults (age ≥65 years) is expected to lead to higher rates of cardiovascular disease. The expansion of digital health (encompassing telehealth, telemedicine, mobile health, and remote patient monitoring), Internet access, and cellular technologies provides an opportunity to enhance patient care and improve health outcomes-opportunities that are particularly relevant during the current coronavirus disease-2019 pandemic. Insufficient dexterity, visual impairment, and cognitive dysfunction, found commonly in older adults should be taken into consideration in the development and utilization of existing technologies. If not implemented strategically and appropriately, these can lead to inequities propagating digital divides among older adults, across disease severities and socioeconomic distributions. A systematic approach, therefore, is needed to study and implement digital health strategies in older adults. This review will focus on current knowledge of the benefits, barriers, and use of digital health in older adults for cardiovascular disease management.
- Published
- 2020
16. Performance of Guideline Recommendations for Prevention of Myocardial Infarction in Young Adults
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Michael G. Nanna, Michel Zeitouni, Eric D. Peterson, Karen Chiswell, Jie Lena Sun, and Ann Marie Navar
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Adult ,Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,University medical ,030212 general & internal medicine ,Myocardial infarction ,Young adult ,Stroke ,Aged ,Retrospective Studies ,business.industry ,Age Factors ,Guideline ,Middle Aged ,medicine.disease ,Practice Guidelines as Topic ,Female ,Statin therapy ,Cardiology and Cardiovascular Medicine ,business ,Very high risk - Abstract
The 2018 cholesterol guidelines of the American Heart Association and the American College of Cardiology (AHA/ACC) changed 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) eligibility criteria for primary prevention to include multiple risk enhancers and novel intensive lipid-lowering therapies for secondary prevention.This study sought to determine how guideline changes affected identification for preventive therapy in young adults with premature myocardial infarction (MI).The study identified adults presenting with first MI at Duke University Medical Center in Durham, North Carolina. Statin therapy eligibility was determined using the 2013 ACC/AHA and 2018 AHA/ACC guidelines criteria. The study also determined potential eligibility for intensive lipid-lowering therapies (very high risk) under the 2018 AHA/ACC guidelines, by assessing the composite of all-cause death, recurrent MI, or stroke rates in adults considered "very high risk" versus not.Among 6,639 patients with MI, 41% were 55 years of age ("younger"), 35% were 55 to 65 years of age ("middle-aged"), and 24% were 66 to 75 years of age ("older"). Younger adults were more frequently smokers (52% vs. 38% vs. 22%, respectively) and obese (42% vs. 34% vs. 31%, respectively), with metabolic syndrome (21% vs. 19% vs. 17%, respectively) and higher low-density lipoprotein cholesterol (117 vs. 107 vs. 103 mg/dl, respectively) (p trend 0.01 for all). Pre-MI, fewer younger adults met guideline indications for 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) therapy than middle-aged and older adults. The 2018 guideline identified fewer younger adults eligible for statin therapy at the time of their MI than the 2013 guideline (46.4% vs. 56.7%; p 0.01). Younger patients less frequently met very high-risk criteria for intensive secondary prevention lipid-lowering therapy (28.3% vs. 40.0% vs. 81.4%, respectively; p 0.01). Over a median 8 years of follow-up, very high-risk criteria were associated with increased risk of major adverse cardiovascular events in individuals 55 years of age (hazard ratio: 2.09; 95% confidence interval: 1.82 to 2.41; p 0.001), as was the case in older age groups (p interaction = 0.54).Most younger patients with premature MI are not identified as statin candidates before their event on the basis of the 2018 guidelines, and most patients with premature MI are not recommended for intensive post-MI lipid management.
- Published
- 2020
17. Cardiovascular Biomarkers and Imaging in Older Adults: JACC Council Perspectives
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Daniel E, Forman, James A, de Lemos, Leslee J, Shaw, David B, Reuben, Radmila, Lyubarova, Eric D, Peterson, John A, Spertus, Susan, Zieman, Marcel E, Salive, and Michael W, Rich
- Subjects
Aging ,Cardiac Imaging Techniques ,Exercise Test ,Humans ,Biomarkers ,Article ,Aged - Abstract
Whereas the burgeoning population of older adults is intrinsically vulnerable to cardiovascular disease, the utility of many management precepts that were validated in younger adults is often unclear. Whereas biomarker- and imaging-based tests are a major part of cardiovascular disease care, basic assumptions about their use and efficacy cannot be simply extrapolated to many older adults. Biology, physiology, and body composition change with aging, with important influences on cardiovascular disease testing procedures and their interpretation. Furthermore, clinical priorities of older adults are more heterogeneous, potentially undercutting the utility of testing data that are collected. The American College of Cardiology and the National Institutes on Aging, in collaboration with the American Geriatrics Society, convened, at the American College of Cardiology Heart House, a 2-day multidisciplinary workshop, “Diagnostic Testing in Older Adults with Cardiovascular Disease,” to address these issues. This review summarizes key concepts, clinical limitations, and important opportunities for research.
- Published
- 2020
18. Using Digital Health Technology to Better Generate Evidence and Deliver Evidence-Based Care
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Steven R. Steinhubl, Andrew Hamer, Robert A. Harrington, James R. Mault, Bakul Patel, Matthew T. Roe, Mintu P. Turakhia, Eric M. Green, Mark McClellan, John S. Rumsfeld, Eric D. Peterson, Abhinav Sharma, Lothar Roessig, Zubin J. Eapen, Jeffrey E. Olgin, Karen J. Chandross, and Maulik D. Majmudar
- Subjects
Clinical Trials as Topic ,Information Age ,Medical education ,Evidence-Based Medicine ,business.industry ,Biomedical Technology ,Information technology ,Evidence-based medicine ,Congresses as Topic ,030204 cardiovascular system & hematology ,Digital health ,Telemedicine ,03 medical and health sciences ,0302 clinical medicine ,Healthcare delivery ,Data quality ,District of Columbia ,Health care ,Humans ,Medicine ,030212 general & internal medicine ,Clinical care ,Cardiology and Cardiovascular Medicine ,business ,Delivery of Health Care - Abstract
As we enter the information age of health care, digital health technologies offer significant opportunities to optimize both clinical care delivery and clinical research. Despite their potential, the use of such information technologies in clinical care and research faces major data quality, privacy, and regulatory concerns. In hopes of addressing both the promise and challenges facing digital health technologies in the transformation of health care, we convened a think tank meeting with academic, industry, and regulatory representatives in December 2016 in Washington, DC. In this paper, we summarize the proceedings of the think tank meeting and aim to delineate a framework for appropriately using digital health technologies in healthcare delivery and research.
- Published
- 2018
19. Care Patterns and Outcomes in Atrial Fibrillation Patients With and Without Diabetes
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Laine Thomas, Bernard J. Gersh, Gregg C. Fonarow, Alan S. Go, Jonathan P. Piccini, Justin B. Echouffo-Tcheugui, Elaine M. Hylek, Eric D. Peterson, Daniel E. Singer, Peter R. Kowey, Kenneth W. Mahaffey, and Peter Shrader
- Subjects
medicine.medical_specialty ,business.industry ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Diabetes mellitus ,Heart failure ,Internal medicine ,Cardiology ,Medicine ,030212 general & internal medicine ,Risk factor ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,Cohort study ,Kidney disease - Abstract
Background Diabetes is a well-established risk factor for thromboembolism in patients with atrial fibrillation (AF), but less is known about how diabetes influences outcomes among AF patients. Objectives This study assessed whether symptoms, health status, care, and outcomes differ between AF patients with and without diabetes. Methods The cohort study included 9,749 patients from the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) registry, a prospective, nationwide, outpatient registry of patients with incident and prevalent AF. Outcomes included symptoms, health status, and AF treatment, as well as 2-year risk of death, hospitalization, thromboembolic events, heart failure (HF), and AF progression. Results Patients with diabetes (29.5%) were younger, more likely to have hypertension, chronic kidney disease, HF, coronary heart disease, and stroke. Compared to patients without diabetes, patients with diabetes also had a lower Atrial Fibrillation Effects on Quality of Life score of 80 (interquartile range [IQR]: 62.5 to 92.6) versus 82.4 (IQR: 67.6 to 93.5; p = 0.025) and were more likely to receive anticoagulation (p Conclusions Among AF patients, diabetes was associated with worse AF symptoms and lower quality of life, and increased risk of death and hospitalizations, but not thromboembolic or bleeding events.
- Published
- 2017
20. Procedural Experience for Transcatheter Aortic Valve Replacement and Relation to Outcomes
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John D. Carroll, E. Murat Tuzcu, Dadi Dai, Eric D. Peterson, Michael J. Mack, Frederick A. Masoudi, Fred H. Edwards, Frederick L. Grover, John S. Rumsfeld, David R. Holmes, Eugene H. Blackstone, Roland A. Matsouaka, and Sreekanth Vemulapalli
- Subjects
Aortic valve ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,Retrospective cohort study ,030204 cardiovascular system & hematology ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Valve replacement ,Learning curve ,Aortic valve stenosis ,Emergency medicine ,medicine ,030212 general & internal medicine ,Heart valve ,Cardiology and Cardiovascular Medicine ,Adverse effect ,business - Abstract
Background Transcatheter aortic valve replacement (TAVR) has been introduced into U.S. clinical practice with efforts to optimize outcomes and minimize the learning curve. Objectives The goal of this study was to assess the degree to which increasing experience during the introduction of this procedure, separated from other outcome determinants including patient and procedural characteristics, is associated with outcomes. Methods The authors evaluated the association of hospital TAVR volume and patient outcomes for TAVR by using data from 42,988 commercial procedures conducted at 395 hospitals submitting to the Transcatheter Valve Therapy Registry from 2011 through 2015. Outcomes assessed included adjusted and unadjusted in-hospital major adverse events. Results Increasing site volume was associated with lower in-hospital risk-adjusted outcomes, including mortality (p Conclusions The initial adoption of TAVR into practice in the United States showed that increasing experience was associated with better outcomes. This association, whether deemed a prolonged learning curve or a manifestation of a volume–outcome relationship, suggested that concentrating experience in higher volume heart valve centers might be a means of improving outcomes. (STS/ACC Transcatheter Valve Therapy Registry [TVT Registry]; NCT01737528 )
- Published
- 2017
21. Transcatheter Versus Surgical Aortic Valve Replacement
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J. Matthew Brennan, Laine Thomas, David J. Cohen, David Shahian, Alice Wang, Michael J. Mack, David R. Holmes, Fred H. Edwards, Naftali Z. Frankel, Suzanne J. Baron, John Carroll, Vinod Thourani, E. Murat Tuzcu, Suzanne V. Arnold, Roberta Cohn, Todd Maser, Brenda Schawe, Susan Strong, Allen Stickfort, Elizabeth Patrick-Lake, Felicia L. Graham, Dadi Dai, Fan Li, Roland A. Matsouaka, Sean O’Brien, Michael J. Pencina, and Eric D. Peterson
- Subjects
Aortic valve ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Odds ratio ,030204 cardiovascular system & hematology ,Rate ratio ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Valve replacement ,Aortic valve replacement ,Aortic valve stenosis ,medicine ,Risk of mortality ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Randomized trials support the use of transcatheter aortic valve replacement (TAVR) for the treatment of aortic stenosis in high- and intermediate-risk patients, but the generalizability of those results in clinical practice has been challenged. Objectives The aim of this study was to determine the safety and effectiveness of TAVR versus surgical aortic valve replacement (SAVR), particularly in intermediate- and high-risk patients, in a nationally representative real-world cohort. Methods Using data from the Transcatheter Valve Therapy Registry and Society of Thoracic Surgeons National Database linked to Medicare administrative claims for follow-up, 9,464 propensity-matched intermediate- and high-risk (Society of Thoracic Surgeons Predicted Risk of Mortality score ≥3%) U.S. patients who underwent commercial TAVR or SAVR were examined. Death, stroke, and days alive and out of the hospital to 1 year were compared, as well as discharge home, with subgroup analyses by surgical risk, demographics, and comorbidities. Results In a propensity-matched cohort (median age 82 years, 48% women, median Society of Thoracic Surgeons Predicted Risk of Mortality score 5.6%), TAVR and SAVR patients experienced no difference in 1-year rates of death (17.3% vs. 17.9%; hazard ratio: 0.93; 95% confidence interval [CI]: 0.83 to 1.04) and stroke (4.2% vs. 3.3%; hazard ratio: 1.18; 95% CI: 0.95 to 1.47), and no difference was observed in the proportion of days alive and out of the hospital to 1 year (rate ratio: 1.00; 95% CI: 0.98 to 1.02). However, TAVR patients were more likely to be discharged home after treatment (69.9% vs. 41.2%; odds ratio: 3.19; 95% CI: 2.84 to 3.58). Results were consistent across most subgroups, including among intermediate- and high-risk patients. Conclusions Among unselected intermediate- and high-risk patients, TAVR and SAVR resulted in similar rates of death, stroke, and DAOH to 1 year, but TAVR patients were more likely to be discharged home.
- Published
- 2017
22. Outcomes of PCI in Relation to Procedural Characteristics and Operator Volumes in the United States
- Author
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Daniel Wojdyla, Mauricio G. Cohen, David Dai, Sunil V. Rao, Hitinder S. Gurm, Alexander C. Fanaroff, Tracy Y. Wang, Matthew W. Sherwood, John C. Messenger, Eric D. Peterson, Matthew T. Roe, and Pearl Zakroysky
- Subjects
Male ,medicine.medical_specialty ,Hospitals, Low-Volume ,medicine.medical_treatment ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Risk Assessment ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Case mix index ,Operator (computer programming) ,Odds Ratio ,Humans ,Medicine ,Hospital Mortality ,Registries ,030212 general & internal medicine ,Aged ,Retrospective Studies ,business.industry ,Absolute risk reduction ,Percutaneous coronary intervention ,Retrospective cohort study ,Odds ratio ,Middle Aged ,United States ,Treatment Outcome ,Conventional PCI ,Emergency medicine ,Female ,Cardiology and Cardiovascular Medicine ,business ,Risk assessment ,Hospitals, High-Volume - Abstract
Professional guidelines have reduced the recommended minimum number to an average of 50 percutaneous coronary intervention (PCI) procedures performed annually by each operator. Operator volume patterns and associated outcomes since this change are unknown.The authors describe herein PCI operator procedure volumes; characteristics of low-, intermediate-, and high-volume operators; and the relationship between operator volume and clinical outcomes in a large, contemporary, nationwide sample.Using data from the National Cardiovascular Data Registry collected between July 1, 2009, and March 31, 2015, we examined operator annual PCI volume. We divided operators into low- (50 PCIs per year), intermediate- (50 to 100 PCIs per year), and high- (100 PCIs per year) volume groups, and determined the adjusted association between annual PCI volume and in-hospital outcomes, including mortality.The median annual number of procedures performed per operator was 59; 44% of operators performed 50 PCI procedures per year. Low-volume operators more frequently performed emergency and primary PCI procedures and practiced at hospitals with lower annual PCI volumes. Unadjusted in-hospital mortality was 1.86% for low-volume operators, 1.73% for intermediate-volume operators, and 1.48% for high-volume operators. The adjusted risk of in-hospital mortality was higher for PCI procedures performed by low- and intermediate-volume operators compared with those performed by high-volume operators (adjusted odds ratio: 1.16 for low versus high; adjusted odds ratio: 1.05 for intermediate vs. high volume) as was the risk for new dialysis post PCI. No volume relationship was observed for post-PCI bleeding.Many PCI operators in the United States are performing fewer than the recommended number of PCI procedures annually. Although absolute risk differences are small and may be partially explained by unmeasured differences in case mix between operators, there remains an inverse relationship between PCI operator volume and in-hospital mortality that persisted in risk-adjusted analyses.
- Published
- 2017
23. Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes
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Daniel E. Singer, Gregg C. Fonarow, Peter Shrader, Orbit-Af Investigators, Benjamin A. Steinberg, James A. Reiffel, Jonathan P. Piccini, Laine Thomas, Bernard Gersh, Eric D. Peterson, Kenneth W. Mahaffey, Gerald V. Naccarelli, Patients, Jack Ansell, and Peter R. Kowey
- Subjects
medicine.medical_specialty ,Rivaroxaban ,business.industry ,medicine.drug_class ,Antagonist ,Atrial fibrillation ,030204 cardiovascular system & hematology ,Vitamin K antagonist ,medicine.disease ,Off-label use ,Gastroenterology ,Dabigatran ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Apixaban ,030212 general & internal medicine ,Dosing ,Intensive care medicine ,business ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
Background: Although non-vitamin K antagonist oral anticoagulants (NOACs) do not require frequent laboratory monitoring, each compound requires dose adjustments on the basis of certain clin...
- Published
- 2016
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24. Has Public Reporting of Hospital Readmission Rates Affected Patient Outcomes?
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Adam D. DeVore, Eric D. Peterson, N. Chantelle Hardy, Adrian F. Hernandez, Zubin J. Eapen, and Bradley G. Hammill
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medicine.medical_specialty ,COPD ,business.industry ,Emergency department ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,Pneumonia ,0302 clinical medicine ,Public reporting ,Acute care ,Heart failure ,Emergency medicine ,medicine ,030212 general & internal medicine ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Medicaid - Abstract
Background In 2009, the Centers for Medicare & Medicaid Services (CMS) began publicly reporting 30-day hospital readmission rates for patients discharged with acute myocardial infarction (MI), heart failure (HF), or pneumonia. Objectives This study assessed trends of 30-day readmission rates and post-discharge care since the implementation of CMS public reporting. Methods We analyzed Medicare claims data from 2006 to 2012 for patients discharged after a hospitalization for MI, HF, or pneumonia. For each diagnosis, we estimated trends in 30-day all-cause readmissions and post-discharge care (emergency department visits and observation stays) by using hospitalization-level regression models. We modeled adjusted trends before and after the implementation of public reporting. To assess for a change in trend, we tested the difference between the slope before implementation and the slope after implementation. Results We analyzed 37,829 hospitalizations for MI, 100,189 for HF, and 79,076 for pneumonia from >4,100 hospitals. When considering only recent trends (i.e., since 2009), we found improvements in adjusted readmission rates for MI (−2.3%), HF (−1.8%), and pneumonia (−2.0%), but when comparing the trend before public reporting with the trend after reporting, there was no difference for MI (p = 0.72), HF (p = 0.19), or pneumonia (p = 0.21). There were no changes in trends for 30-day post-discharge care for MI or pneumonia; however, the trend decreased for HF emergency department visits from 2.3% to −0.8% (p = 0.007) and for observation stays from 15.1% to 4.1% (p = 0.04). Conclusions The release of the CMS public reporting of hospital readmission rates was not associated with any measurable change in 30-day readmission trends for MI, HF, or pneumonia, but it was associated with less hospital-based acute care for HF.
- Published
- 2016
25. Impact of Bleeding on Quality of Life in Patients on DAPT
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Eric D. Peterson, Richard G. Bach, Amit P. Amin, Mark B. Effron, Lisa A. McCoy, Tracy Y. Wang, and David J. Cohen
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Acute coronary syndrome ,medicine.medical_specialty ,business.industry ,Visual analogue scale ,medicine.medical_treatment ,Percutaneous coronary intervention ,030204 cardiovascular system & hematology ,medicine.disease ,3. Good health ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,Conventional PCI ,medicine ,Platelet aggregation inhibitor ,030212 general & internal medicine ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Cohort study - Abstract
Background Prolonged dual antiplatelet therapy (DAPT) is recommended after an acute myocardial infarction (AMI) to reduce ischemic events but is associated with increased rates of major and minor bleeding. Objectives This study sought to determine the incidence of post-percutaneous coronary intervention (PCI) bleeding that occurs on contemporary DAPT and its impact on quality of life (QOL). Methods We studied 9,290 AMI patients treated with PCI and discharged alive between April 2010 and September 2012. Post-discharge bleeding was categorized according to the Bleeding Academic Research Consortium (BARC) definition. The primary outcome was the 6-month Euro QOL–5 Dimension (EQ-5D) index score (a measure of health utility); a secondary outcome was the EQ-5D visual analog scale (VAS) at 6 months. Results Of the 9,290 patients with AMI, bleeding events occurred as follows: any BARC bleeding: 24.2%; BARC 1: 9.1%; BARC 2: 13.8%; BARC 3: 1.1%; BARC 4: 0.03%; and BARC 5: 0%. Those who experienced any BARC bleeding had lower scores across all 5 EQ-5D domains (mobility, self-care, usual activities, pain, and anxiety), as well as lower EQ-5D VAS and EQ-5D index scores. After clinical risk adjustment, any BARC bleeding was independently associated with 6-month EQ-5D index score (p Conclusions Among patients undergoing PCI for AMI, bleeding during follow-up was associated with worse 6-month utility and QOL. Although even minor bleeding was associated with impaired health status and QOL, the degree of impairment increased in a stepwise fashion with bleeding severity.
- Published
- 2016
26. Annual Outcomes With Transcatheter Valve Therapy
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Sts, Michael J. Mack, Frederick L. Grover, John S. Rumsfeld, Rick A. Nishimura, Fred H. Edwards, John D. Carroll, David R. Holmes, Ralph G. Brindis, David M. Shahian, Eric D. Peterson, Susan Fitzgerald, Acc Tvt Registry, E. Murat Tuzcu, Sreekanth Vemulapalli, Kathleen Hewitt, Joan Michaels, and Vinod H. Thourani
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Percutaneous techniques ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Aortic valve replacement ,Valve replacement ,Health care ,Risk of mortality ,Medicine ,030212 general & internal medicine ,Stroke ,Cardiac catheterization ,Moderate sedation ,business.industry ,valvular heart disease ,medicine.disease ,Surgery ,Kansas City Cardiomyopathy Questionnaire ,Walk test ,Emergency medicine ,business ,Cardiology and Cardiovascular Medicine - Abstract
Background The Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry has been a joint initiative of the STS and the ACC in concert with multiple stakeholders. The TVT Registry has important information regarding patient selection, delivery of care, science, education, and research in the field of structural valvular heart disease. Objectives This report provides an overview on current U.S. TVT practice and trends. The emphasis is on demographics, in-hospital procedural characteristics, and outcomes of patients having transcatheter aortic valve replacement (TAVR) performed at 348 U.S. centers. Methods The TVT Registry captured 26,414 TAVR procedures as of December 31, 2014. Temporal trends between 2012 and 2013 versus 2014 were compared. Results Comparison of the 2 time periods reveals that TAVR patients remain elderly (mean age 82 years), with multiple comorbidities, reflected by a high mean STS predicted risk of mortality (STS PROM) for surgical valve replacement (8.34%), were highly symptomatic (New York Heart Association functional class III/IV in 82.5%), frail (slow 5-m walk test in 81.6%), and have poor self-reported health status (median baseline Kansas City Cardiomyopathy Questionnaire score of 39.1). Procedure performance is changing, with an increased use of moderate sedation (from 1.6% to 5.1%) and increase in femoral access using percutaneous techniques (66.8% in 2014). Vascular complication rates are decreasing (from 5.6% to 4.2%), whereas site-reported stroke rates remain stable at 2.2%. Conclusions The TVT Registry provides important information on characteristics and outcomes of TAVR in contemporary U.S. clinical practice. It can be used to identify trends in practice and opportunities for quality improvement.
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- 2015
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27. 'Sticky' Issues for Adherence in Secondary Prevention
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Eric D. Peterson and Ann Marie Navar
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Secondary prevention ,medicine.medical_specialty ,business.industry ,Behavioural sciences ,Medication adherence ,Patient engagement ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,medicine ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business - Published
- 2017
28. When Less Is Not More ∗
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Eric D. Peterson, Sean D. Pokorney, and Jonathan P. Piccini
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medicine.medical_specialty ,business.industry ,MEDLINE ,Warfarin ,Renal function ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Anesthesia ,medicine ,Cardiology ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,medicine.drug - Published
- 2017
29. EVALUATING THE 2018 AHA/ACC LIPID GUIDELINE PERFORMANCE TO IDENTIFY PATIENTS AT HIGH RISK FOR PREMATURE CARDIOVASCULAR DISEASE
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Michel Zeitouni, Michael G. Nanna, Eric D. Peterson, Jie-Lena Sun, Karen Chiswell, and Ann Marie Navar
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medicine.medical_specialty ,Statin ,Cholesterol ,business.industry ,medicine.drug_class ,Disease ,Guideline ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Primary prevention ,medicine ,Young adult ,Cardiology and Cardiovascular Medicine ,business - Abstract
The 2018 American Heart Association/American College of Cardiology cholesterol guideline changed statin eligibility criteria for primary prevention to include multiple new risk “enhancers”. Whether this improved identification of young adults at risk for premature CVD compared with the prior
- Published
- 2020
30. Cardiovascular Drug Development
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Jeffrey S. Borer, Katharine Cooper-Arnold, Scott D. Berkowitz, Rob Scott, Paul W. Armstrong, Robert M. Califf, David L. DeMets, Jayne Prats, Michael R. Bristow, Tariq Ahmad, Bertram Pitt, Scott M. Wasserman, Eric D. Peterson, William R. Hiatt, Milton Packer, Matthew T. Roe, Zorina S. Galis, Norman Stockbridge, Ned Braunstein, Christopher B. Fordyce, and Peter Libby
- Subjects
Economic growth ,Government ,Pathology ,medicine.medical_specialty ,business.industry ,Context (language use) ,Disease ,Clinical trial ,Cardiovascular agent ,Medicine ,Review process ,Cardiovascular drug ,Risks and benefits ,Cardiology and Cardiovascular Medicine ,business - Abstract
Despite the global burden of cardiovascular disease, investment in cardiovascular drug development has stagnated over the past 2 decades, with relative underinvestment compared with other therapeutic areas. The reasons for this trend are multifactorial, but of primary concern is the high cost of conducting cardiovascular outcome trials in the current regulatory environment that demands a direct assessment of risks and benefits, using clinically-evident cardiovascular endpoints. To work toward consensus on improving the environment for cardiovascular drug development, stakeholders from academia, industry, regulatory bodies, and government agencies convened for a think tank meeting in July 2014 in Washington, DC. This paper summarizes the proceedings of the meeting and aims to delineate the current adverse trends in cardiovascular drug development, understand the key issues that underlie these trends within the context of a recognized need for a rigorous regulatory review process, and provide potential solutions to the problems identified.
- Published
- 2015
31. Using Age- and Sex-Specific Risk Thresholds to Guide Statin Therapy
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Michael J. Pencina, Ralph B. D'Agostino, Allan D. Sniderman, Ann Marie Navar-Boggan, and Eric D. Peterson
- Subjects
medicine.medical_specialty ,Framingham Risk Score ,Statin ,business.industry ,medicine.drug_class ,Cholesterol ,Offspring ,Specific risk ,Disease ,030204 cardiovascular system & hematology ,Age and sex ,3. Good health ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Internal medicine ,Physical therapy ,medicine ,cardiovascular diseases ,030212 general & internal medicine ,Statin therapy ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background New cholesterol guidelines emphasize 10-year risk of cardiovascular disease (CVD) to identify adults eligible for statin therapy as primary prevention. Whether these CVD risk thresholds should be individualized by age and sex has not been explored. Objectives This study evaluated the potential impact of incorporating age- and sex-specific CVD risk thresholds into current cholesterol guidelines. Methods Using data from the Framingham Offspring Study, this study assessed current treatment recommendations among age- and sex-specific groups in 3,685 participants free of CVD. Then, it evaluated how varying age- and sex-specific 10-year CVD risk thresholds for statin treatment affect the sensitivity and specificity for incident 10-year CVD events. Results Basing statin therapy recommendations on a 10-year fixed risk threshold of 7.5% results in lower statin consideration among women than men (63% vs. 33%; p Conclusions Cholesterol treatment recommendations could be improved by using individualized age- and sex-specific CVD risk thresholds.
- Published
- 2015
32. Trends in Settings for Peripheral Vascular Intervention and the Effect of Changes in the Outpatient Prospective Payment System
- Author
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W. Schuyler Jones, Eric D. Peterson, Lesley H. Curtis, Xiaojuan Mi, Manesh R. Patel, Sreekanth Vemulapalli, and Laura G. Qualls
- Subjects
medicine.medical_specialty ,Arterial disease ,business.industry ,medicine.medical_treatment ,Reimbursement rates ,PERIPHERAL VASCULAR INTERVENTION ,atherectomy ,Medicare ,Revascularization ,Atherectomy ,peripheral arterial disease ,Emergency medicine ,Physical therapy ,vascular surgical procedures ,Medicine ,Effective treatment ,Prospective payment system ,Cardiology and Cardiovascular Medicine ,business ,Reimbursement - Abstract
BackgroundPeripheral vascular intervention (PVI) is an effective treatment option for patients with peripheral artery disease (PAD). In 2008, Medicare modified reimbursement rates to encourage more efficient outpatient use of PVI in the United States.ObjectivesThe purpose of this study was to evaluate trends in the use and clinical settings of PVI and the effect of changes in reimbursement.MethodsUsing a 5% national sample of Medicare fee-for-service beneficiaries from 2006 to 2011, we examined age- and sex-adjusted rates of PVI by year, type of procedure, clinical setting, and physician specialty.ResultsA total of 39,339 Medicare beneficiaries underwent revascularization for PAD between 2006 and 2011. The annual rate of PVI increased slightly from 401.4 to 419.6 per 100,000 Medicare beneficiaries (p = 0.17), but the clinical setting shifted. The rate of PVI declined in inpatient settings from 209.7 to 151.6 (p < 0.001), whereas the rate expanded in outpatient hospitals (184.7 to 228.5; p = 0.01) and office-based clinics (6.0 to 37.8; p = 0.008). The use of atherectomy increased 2-fold in outpatient hospital settings and 50-fold in office-based clinics during the study period. Mean costs of inpatient procedures were similar across all types of PVI, whereas mean costs of atherectomy procedures in outpatient and office-based clinics exceeded those of stenting and angioplasty procedures.ConclusionsFrom 2006 to 2011, overall rates of PVI increased minimally. However, after changes in reimbursement, PVI and atherectomy in outpatient facilities and office-based clinics increased dramatically, neutralizing cost savings to Medicare and highlighting the possible unintended consequences of coverage decisions.
- Published
- 2015
33. 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: Executive Summary
- Author
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David R. Holmes, Debabrata Mukherjee, Hani Jneid, Susan J. Zieman, Allan S. Jaffe, Theodore G. Ganiats, Ezra A. Amsterdam, Rosemary F. Kelly, Donald E. Casey, Michael C. Kontos, Nanette K. Wenger, Marc S. Sabatine, Eric D. Peterson, Philip R. Liebson, Glenn N. Levine, Richard W. Smalling, and Ralph G. Brindis
- Subjects
medicine.medical_specialty ,Acute coronary syndrome ,Executive summary ,medicine.diagnostic_test ,Task force ,business.industry ,medicine.medical_treatment ,ST elevation ,Percutaneous coronary intervention ,Guideline ,medicine.disease ,Internal medicine ,medicine ,Cardiology ,Myocardial infarction ,business ,Cardiology and Cardiovascular Medicine ,Electrocardiography - Abstract
Preamble 2356 1. Introduction 2357 2. Overview of Acs 2358 3. Initial Evaluation and Management: Recommendations 2358 4. Early Hospital Care: Recommendations 2363 5. Myocardial Revascularization: Recommendations 2369 6. Late Hospital Care, Hospital Discharge, and Posthospital Discharge Care: Recommendations 2371
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- 2014
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34. 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
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Richard W. Smalling, David R. Holmes, Hani Jneid, Glenn N. Levine, Susan J. Zieman, Debabrata Mukherjee, Allan S. Jaffe, Rosemary F. Kelly, Eric D. Peterson, Marc S. Sabatine, Theodore G. Ganiats, Ezra A. Amsterdam, Nanette K. Wenger, Michael C. Kontos, Philip R. Liebson, Donald E. Casey, and Ralph G. Brindis
- Subjects
Secondary prevention ,medicine.medical_specialty ,Task force ,business.industry ,Internal medicine ,ST elevation ,medicine ,Cardiology ,Guideline ,Cardiology and Cardiovascular Medicine ,business - Abstract
Jeffrey L. Anderson, MD, FACC, FAHA, Chair Jonathan L. Halperin, MD, FACC, FAHA, Chair-Elect Nancy M. Albert, PhD, RN, FAHA Biykem Bozkurt, MD, PhD, FACC, FAHA Ralph G. Brindis, MD, MPH, MACC Lesley H. Curtis, PhD, FAHA David DeMets, PhD[††][1] Lee A. Fleisher, MD, FACC, FAHA Samuel
- Published
- 2014
35. ACC/AHA/AACVPR/AAFP/ANA Concepts for Clinician–Patient Shared Accountability in Performance Measures
- Author
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Frederick A. Masoudi, Mary B. Barton, Marjorie L. King, Kathleen L. Grady, David R. Nielsen, Gregg C. Fonarow, Donald E. Casey, L. Hayley Burgess, Eric D. Peterson, Dana E. King, Stephen J. Stanko, David Goff, P. Michael Ho, Joseph P. Drozda, and Craig Beam
- Subjects
Gerontology ,medicine.medical_specialty ,business.industry ,Task force ,Family medicine ,Accountability ,Medicine ,Quality measurement ,business ,Cardiology and Cardiovascular Medicine - Abstract
Paul A. Heidenreich, MD, MS, FACC, FAHA, Chair Nancy M. Albert, PhD, CCNS, CCRN, FAHA Paul S. Chan, MD, MSc, FACC Lesley H. Curtis, PhD T. Bruce Ferguson, Jr, MD, FACC Gregg C. Fonarow, MD, FACC, FAHA P. Michael Ho, MD, PhD, FACC, FAHA Corrine Jurgens, PhD, RN, ANP-BC, FAHA Sean O’Brien
- Published
- 2014
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36. New Treatment Options Fail to Close the Anticoagulation Gap in Atrial Fibrillation
- Author
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Sean D. Pokorney and Eric D. Peterson
- Subjects
medicine.medical_specialty ,business.industry ,Treatment options ,Anticoagulants ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,Stroke ,03 medical and health sciences ,0302 clinical medicine ,Stroke prevention ,Internal medicine ,Atrial Fibrillation ,Oral anticoagulant ,medicine ,Cardiology ,Humans ,Thrombolytic Therapy ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business - Published
- 2017
37. Procedural Experience for Transcatheter Aortic Valve Replacement and Relation to Outcomes: The STS/ACC TVT Registry
- Author
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John D, Carroll, Sreekanth, Vemulapalli, Dadi, Dai, Roland, Matsouaka, Eugene, Blackstone, Fred, Edwards, Frederick A, Masoudi, Michael, Mack, Eric D, Peterson, David, Holmes, John S, Rumsfeld, E Murat, Tuzcu, and Frederick, Grover
- Subjects
Aged, 80 and over ,Male ,Health Policy ,Incidence ,Aortic Valve Stenosis ,United States ,Transcatheter Aortic Valve Replacement ,Postoperative Complications ,Aortic Valve ,Humans ,Female ,Clinical Competence ,Registries ,Societies, Medical ,Aged ,Retrospective Studies - Abstract
Transcatheter aortic valve replacement (TAVR) has been introduced into U.S. clinical practice with efforts to optimize outcomes and minimize the learning curve.The goal of this study was to assess the degree to which increasing experience during the introduction of this procedure, separated from other outcome determinants including patient and procedural characteristics, is associated with outcomes.The authors evaluated the association of hospital TAVR volume and patient outcomes for TAVR by using data from 42,988 commercial procedures conducted at 395 hospitals submitting to the Transcatheter Valve Therapy Registry from 2011 through 2015. Outcomes assessed included adjusted and unadjusted in-hospital major adverse events.Increasing site volume was associated with lower in-hospital risk-adjusted outcomes, including mortality (p 0.02), vascular complications (p 0.003), and bleeding (p 0.001) but was not associated with stroke (p = 0.14). From the first case to the 400th case in the volume-outcome model, risk-adjusted adverse outcomes declined, including mortality (3.57% to 2.15%), bleeding (9.56% to 5.08%), vascular complications (6.11% to 4.20%), and stroke (2.03% to 1.66%). Vascular and bleeding volume-outcome associations were nonlinear with a higher risk of adverse outcomes in the first 100 cases. An association of procedure volume with risk-adjusted outcomes was also seen in the subgroup having transfemoral access.The initial adoption of TAVR into practice in the United States showed that increasing experience was associated with better outcomes. This association, whether deemed a prolonged learning curve or a manifestation of a volume-outcome relationship, suggested that concentrating experience in higher volume heart valve centers might be a means of improving outcomes. (STS/ACC Transcatheter Valve Therapy Registry [TVT Registry]; NCT01737528).
- Published
- 2017
38. ACC/AHA Statement on Cost/Value Methodology in Clinical Practice Guidelines and Performance Measures
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Leslee J. Shaw, Jonathan L. Halperin, Paul A. Heidenreich, Mark A. Hlatky, Jeffrey L. Anderson, Alice K. Jacobs, Frederick A. Masoudi, Raymond J. Gibbons, Paul G. Barnett, Mark A. Creager, Daniel B. Mark, Gregg C. Fonarow, and Eric D. Peterson
- Subjects
Clinical Practice ,Actuarial science ,business.industry ,Statement (logic) ,Health care ,Perspective (graphical) ,Value (economics) ,Liberian dollar ,Medicine ,Best value ,Health benefits ,business ,Cardiology and Cardiovascular Medicine - Abstract
Traditionally, resource utilization and value considerations have been explicitly excluded from practice guidelines and performance measures formulations, although they often are implicitly considered. This document challenges this historical policy. With accelerating healthcare costs and the desire to achieve the best value (health benefit for every dollar spent), there is growing recognition of the need for more explicit and transparent assessment of the value of health care. Thus, from a societal policy perspective, a critical healthcare …
- Published
- 2014
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39. Trends in the Use and Outcomes of Ventricular Assist Devices Among Medicare Beneficiaries, 2006 Through 2011
- Author
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Zubin J. Eapen, Lesley H. Curtis, Eric D. Peterson, Joseph G. Rogers, Carmelo A. Milano, Bradley G. Hammill, Adrian F. Hernandez, Prateeti Khazanie, and Chetan B. Patel
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Male ,medicine.medical_specialty ,Databases, Factual ,medicine.medical_treatment ,Treatment outcome ,Hospital mortality ,Medicare ,Patient Readmission ,Risk Assessment ,Article ,outcomes research ,Postoperative Complications ,Cause of Death ,Confidence Intervals ,medicine ,Humans ,Hospital Mortality ,cardiovascular diseases ,Intensive care medicine ,ventricular assist device ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Cause of death ,Heart Failure ,business.industry ,Medicare beneficiary ,Retrospective cohort study ,Health Care Costs ,Middle Aged ,Survival Analysis ,United States ,3. Good health ,Treatment Outcome ,Ventricular assist device ,Female ,Heart-Assist Devices ,Outcomes research ,business ,Risk assessment ,Cardiology and Cardiovascular Medicine - Abstract
ObjectivesThis study sought to examine trends in mortality, readmission, and costs among Medicare beneficiaries receiving ventricular assist devices (VADs) and associations between hospital-level procedure volume and outcomes.BackgroundVADs are an option for patients with advanced heart failure, but temporal changes in outcomes and associations between facility-level volume and outcomes are poorly understood.MethodsThis is a population-based, retrospective cohort study of all fee-for-service Medicare beneficiaries with heart failure who received an implantable VAD between 2006 and 2011. We used Cox proportional hazards models to examine temporal changes in mortality, readmission, and hospital-level procedure volume.ResultsAmong 2,507 patients who received a VAD at 103 centers during the study period, the in-hospital mortality decreased from 30% to 10% (p < 0.001), the 1-year mortality decreased from 42% to 26% (p < 0.001), and the all-cause readmission was frequent (82% and 81%; p = 0.70). After covariate adjustment, in-hospital and 1-year mortality decreased (p < 0.001 for both), but the all-cause readmission did not change (p = 0.82). Hospitals with a low procedure volume had higher risks of in-hospital mortality (risk ratio: 1.72; 95% confidence interval [CI]: 1.28 to 2.33) and 1-year mortality (risk ratio: 1.55; 95% CI: 1.24 to 1.93) than high-volume hospitals. Procedure volume was not associated with risk of readmission. The greatest cost was from the index hospitalization and remained unchanged ($204,020 in 2006 and $201,026 in 2011; p = 0.21).ConclusionsShort- and long-term mortality after VAD implantation among Medicare beneficiaries improved, but readmission remained similar over time. A higher volume of VAD implants was associated with lower risk of mortality but not readmission. Costs to Medicare have not changed in recent years.
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- 2014
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40. Developing a Risk Model for In-Hospital Adverse Events Following Implantable Cardioverter-Defibrillator Implantation
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Ncdr, Jeptha P. Curtis, Sana M. Al-Khatib, Mark S. Kremers, John A. Dodson, Matthew R. Reynolds, Eric D. Peterson, Michael J. Mirro, and Haikun Bao
- Subjects
medicine.medical_specialty ,Pediatrics ,Framingham Risk Score ,business.industry ,medicine.medical_treatment ,Implantable cardioverter-defibrillator ,Logistic regression ,Case mix index ,Interquartile range ,Emergency medicine ,Cohort ,medicine ,Risk assessment ,business ,Adverse effect ,Cardiology and Cardiovascular Medicine - Abstract
Objectives To better inform patients and physicians of the expected risk of adverse events and to assist hospitals9 efforts to improve the outcomes of patients undergoing implantable cardioverter-defibrillator (ICD) implantation, we developed and validated a risk model using data from the NCDR (National Cardiovascular Data Registry) ICD Registry. Background ICD prolong life in selected patients, but ICD implantation carries the risk of periprocedural complications. Methods We analyzed data from 240,632 ICD implantation procedures between April 1, 2010, and December 31, 2011 in the registry. The study group was divided into a derivation (70%) and a validation (30%) cohort. Multivariable logistic regression was used to identify factors associated with in-hospital adverse events (complications or mortality). A parsimonious risk score was developed on the basis of beta estimates derived from the logistic model. Hierarchical models were then used to calculate risk-standardized complication rates to account for differences in case mix and procedural volume. Results Overall, 4,388 patients (1.8%) experienced at least 1 in-hospital complication or death. Thirteen factors were independently associated with an increased risk of adverse outcomes. Model performance was similar in the derivation and validation cohorts (C-statistics = 0.724 and 0.719, respectively). The risk score characterized patients into low- and-high risk subgroups for adverse events (≤10 points, 0.3%; ≥30 points, 4.2%). The risk-standardized complication rates varied significantly across hospitals (median: 1.77, interquartile range 1.54, 2.14, 5th/95th percentiles: 1.16/3.15). Conclusions We developed a simple model that predicts risk for in-hospital adverse events among patients undergoing ICD placement. This can be used for shared decision making and to benchmark hospital performance.
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- 2014
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41. Normal Coronary Rates for Elective Angiography in the Veterans Affairs Healthcare System
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Gary K. Grunwald, Steven M. Bradley, Eric D. Peterson, Maggie A. Stanislawski, Thomas M. Maddox, John S. Rumsfeld, Thomas T. Tsai, P. Michael Ho, and Colin O'Donnell
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Cart ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,medicine.disease ,Appropriate Use Criteria ,Coronary artery disease ,Quartile ,Interquartile range ,Internal medicine ,Angiography ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Veterans Affairs ,Cardiac catheterization - Abstract
Objectives This study sought to determine if an integrated healthcare system is selective and consistent in the use of angiography, as reflected by normal coronary rates. Background Rates of normal coronary arteries with elective coronary angiography vary considerably among U.S. community hospitals. This variation may in part reflect incentives in fee-for-service care. Methods Using national data from the Veterans Affairs (VA) Clinical Assessment Reporting and Tracking (CART) program representing all 76 VA cardiac catheterization laboratories, we evaluated all patients who underwent elective coronary angiography from October 2007 to September 2010. Normal coronary angiography was defined as Results Overall, 4,829 of 22,538 patients (21.4%) had normal coronary angiography. Hospital proportions of normal coronaries varied markedly (median hospital proportion 20.5%; interquartile range: 15.1% to 25.3%; range: 5.5% to 48.5%). Categorized as hospital quartiles, the median proportion of normal coronaries in the lowest quartile was 10.8%, as compared with a median proportion of 19.1% in the second lowest quartile, 23.1% in the second highest quartile, and 30.3% in the highest quartile. Hospitals with lower rates of normal coronaries had higher rates of obstructive coronary disease (59.2% vs. 51.3% vs. 52.6% vs. 44.3%; p Conclusions Approximately 1 in 5 patients undergoing elective coronary angiography in the VA had normal coronaries. This rate is lower than prior published studies in other systems. However, the observed hospital-level variation in normal coronary rates suggests opportunities to improve patient selection for diagnostic coronary angiography.
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- 2014
42. PROVIDER-LEVEL VARIABILITY IN THE TREATMENT OF PATIENTS WITH SEVERE SYMPTOMATIC AORTIC VALVE STENOSIS
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Vinod H. Thourani, Isabel Boero, Alex Bryant, Eric D. Peterson, Sreekanth Vemulapalli, Martin B. Leon, J. Matthew Brennan, and Tracy Y. Wang
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medicine.medical_specialty ,business.industry ,High mortality ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Aortic valve replacement ,Quality of life ,Internal medicine ,Aortic valve stenosis ,cardiovascular system ,medicine ,Cardiology ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,Symptomatic aortic stenosis ,business - Abstract
Patients with severe symptomatic aortic stenosis (ssAS) have high mortality and compromised quality of life without aortic valve replacement (AVR), whether surgical or transcatheter. The role of cardiologists in facilitating access to AVR is not well understood. Natural language processing of
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- 2019
43. THE IMPACT OF HYPERLIPIDEMIA ON CARDIOVASCULAR RISK IN OLDER ADULTS AGE ≥ 75: RESULTS FROM THE NHLBI POOLED COHORTS
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Eric D. Peterson, Daniel Wojdyla, Michael G. Nanna, and Ann Marie Navar
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medicine.medical_specialty ,Increased risk ,Atherosclerotic cardiovascular disease ,business.industry ,Internal medicine ,Hyperlipidemia ,Early adulthood ,medicine ,Risk factor ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Abstract
Elevated LDL-C in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). However, the degree to which LDL-C remains a risk factor (RF) among older adults without ASCVD is less clear. We identified 2667 older adults ≥75 years (59% female) without prior
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- 2019
44. STATIN THERAPY IN PATIENTS WITH CEREBROVASCULAR DISEASE VERSUS CORONARY ARTERY DISEASE: INSIGHTS FROM THE PALM REGISTRY
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Peter W. F. Wilson, Zhuokai Li, Andrew Koren, Michael J. Louie, Eric D. Peterson, Shuang Li, Ying Xian, Ann Marie Navar, Tracy Y. Wang, Jennifer C. Robinson, Véronique L. Roger, Anne C. Goldberg, and Salim S. Virani
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Coronary artery disease ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,In patient ,Statin therapy ,Cardiology and Cardiovascular Medicine ,Palm ,business ,medicine.disease - Published
- 2019
45. RACE AND SEX-BASED DISPARITIES PERSIST IN THE TREATMENT OF PATIENTS WITH SEVERE, SYMPTOMATIC AORTIC VALVE STENOSIS
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Alex Bryant, Tracy Y. Wang, J. Matthew Brennan, Eric D. Peterson, Isabel Boero, Sreekanth Vemulapalli, Martin B. Leon, and Vinod H. Thourani
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medicine.medical_specialty ,Transcatheter aortic ,business.industry ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Health records ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Valve replacement ,Aortic valve stenosis ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Transcatheter aortic valve replacement (TAVR) has revolutionized the care of patients with severe symptomatic aortic valve stenosis (ssAS); however, it remains unknown whether dissemination of this technology has been equitable. Natural language processing of electronic health records in the claims
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- 2019
46. ASSOCIATIONS BETWEEN BETA-BLOCKER THERAPY AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH DIABETES AND ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE: INSIGHTS FROM THE TECOS STUDY
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Paul W. Armstrong, Matthew T. Roe, Cynthia M. Westerhout, Yinggan Zheng, Darren K. McGuire, Jay Shavadia, Eric D. Peterson, Jennifer B. Green, Jan H. Cornel, and Rury R. Holman
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Secondary prevention ,medicine.medical_specialty ,Proportional hazards model ,Atherosclerotic cardiovascular disease ,Beta blocker therapy ,business.industry ,Type 2 diabetes ,medicine.disease ,Diabetes mellitus ,Internal medicine ,medicine ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Cardiovascular outcomes - Abstract
The secondary prevention effects of beta-blocker therapy (BBT) in type 2 diabetes (T2D) and established atherosclerotic cardiovascular disease (ASCVD) are unclear. Using an inverse probability of treatment-weighted Cox proportional hazards model, we examined the association between baseline BBT and
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- 2019
47. THE IMPACT OF TEMPORARY INTERRUPTIONS OF WARFARIN ON DOWNSTREAM TIME IN THERAPEUTIC RANGE IN PATIENTS WITH ATRIAL FIBRILLATION: RESULTS FROM ORBIT AF
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DaJuanicia N. Holmes, Larry A. Allen, Malini Madhavan, Kenneth W. Mahaffey, James V. Freeman, Benjamin A. Steinberg, Jonathan P. Piccini, Paul K.S. Chan, Karen S. Pieper, Gerald V. Naccarelli, James A. Reiffel, Eric D. Peterson, Peter R. Kowey, Elaine M. Hylek, Bernard J. Gersh, Gregg C. Fonarow, and Daniel E. Singer
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endocrine system ,medicine.medical_specialty ,genetic structures ,business.industry ,Warfarin ,Time in therapeutic range ,On warfarin ,Atrial fibrillation ,medicine.disease ,Outcomes Registry ,Internal medicine ,medicine ,Cardiology ,heterocyclic compounds ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Temporary interruption (TI) of warfarin in atrial fibrillation (AF) may be associated with subsequent sub- or supra-therapeutic INR. Our objective was to study time in therapeutic range (TTR) before and after a TI. AF patients on warfarin who had a TI followed by resumption in the Outcomes Registry
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- 2019
48. PRACTICE-LEVEL VARIATION IN STATIN USE AND LDL-C CONTROL IN THE UNITED STATES: RESULTS FROM THE PATIENT AND PROVIDER ASSESSMENT OF LIPID MANAGEMENT (PALM) REGISTRY
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Michael J. Louie, Eric D. Peterson, Andrew Koren, Zhuokai Li, Shuang Li, Peter W.F. Wilson, Jennifer C. Robinson, Véronique L. Roger, Ann Marie Navar, Michael G. Nanna, Anne C. Goldberg, Salim S. Virani, and Tracy Y. Wang
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medicine.medical_specialty ,Lipid management ,Statin ,Atherosclerotic cardiovascular disease ,business.industry ,medicine.drug_class ,Internal medicine ,medicine ,lipids (amino acids, peptides, and proteins) ,Statin treatment ,Cardiology and Cardiovascular Medicine ,business ,Palm - Abstract
Adherence to statin recommendations in the US remains suboptimal yet how this varies across practices is unknown. Variation in statin use and LDL-C levels was examined across 74 U.S. clinics enrolling ≥20 patients with known or at high risk for atherosclerotic cardiovascular disease (ASCVD) in
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- 2019
49. PATIENT PERCEPTIONS AND MANAGEMENT OF CHOLESTEROL AMONG INDIVIDUALS WITH OR WITHOUT DIABETES IN COMMUNITY PRACTICE: RESULTS FROM THE PALM REGISTRY
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Angela Lowenstern, Shuang Li, Michael J. Louie, Anne C. Goldberg, Tracy Y. Wang, Jennifer C. Robinson, Salim S. Virani, Eric D. Peterson, Véronique L. Roger, Ann Marie Navar, and Andrew Koren
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medicine.medical_specialty ,business.industry ,Cholesterol ,nutritional and metabolic diseases ,Statin treatment ,medicine.disease ,Medical care ,chemistry.chemical_compound ,Patient perceptions ,chemistry ,Diabetes mellitus ,Community practice ,Medicine ,lipids (amino acids, peptides, and proteins) ,Statin therapy ,Cardiology and Cardiovascular Medicine ,business ,Palm ,Intensive care medicine - Abstract
Current ACC/AHA cholesterol guidelines and ADA Standards of Medical Care recommend at least moderate-intensity statin therapy for individuals with diabetes mellitus (DM). We compared statin use, patient-perceived cardiovascular (CV) risk and treatment concerns among 2,943 patients with DM and 4,685
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- 2019
50. NON VITAMIN K ORAL ANTICOAGULANTS ARE NOT ASSOCIATED WITH INCREASED RISK OF PERIOPERATIVE BLEEDING IN PATIENTS UNDERGOING CARDIAC SURGERY
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James V. Freeman, Eric D. Peterson, Kenneth W. Mahaffey, Paul S. Chan, Gregg C. Fonarow, Benjamin A. Steinberg, Michael D. Ezekowitz, Nathan H. Waldron, Larry A. Allen, James Reiffel, Elaine M. Hylek, Daniel E. Singer, Jonathan P. Piccini, Bernard Gersh, Peter Shrader, Jerrold H. Levy, Gerald Naccarelli, and Peter R. Kowey
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medicine.medical_specialty ,business.industry ,Atrial fibrillation ,Perioperative ,Vitamin k ,medicine.disease ,Cardiac surgery ,Increased risk ,Stroke prevention ,Anesthesia ,medicine ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Major bleeding - Abstract
Oral anticoagulation (OAC) is frequently used for stroke prevention in patients with atrial fibrillation (AF).1 In AF patients, non-surgical major bleeding may be less common with non vitamin K OAC (NOACs) than with warfarin,2, 3 but there is a paucity of data regarding bleeding risk with NOACs in
- Published
- 2019
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