1. Bioactive peptides: x-ray and NMR conformational study of [Aib5,6-D-Ala8]cyclolinopeptide A
- Author
-
Ettore Benedetti, Benedetto Di Blasio, Michele Saviano, Filomena Rossi, Giancarlo Zanotti, Carlo Pedone, Teodorico Tancredi, and Vincenzo Pavone
- Subjects
chemistry.chemical_classification ,Stereochemistry ,Hydrogen bond ,X-ray ,Peptide ,General Chemistry ,Crystal structure ,Nuclear magnetic resonance spectroscopy ,Ring (chemistry) ,Biochemistry ,Catalysis ,Colloid and Surface Chemistry ,chemistry ,Cyclolinopeptide A ,Orthorhombic crystal system - Abstract
The conformational analysis of [Aib 5,6 -D-Ala 8 ]cyclolinopeptide A, in the solid state and solution, has been carried out by X-ray diffraction and NMR spectroscopy. The structure of the orthorhombic form, obtained from methanol-water mixture [a=29.92 (3) A b=19.85 (3) A, c=9.90 (1) A, space group P2 1 2 1 2 1 Z=4], shows the presence of five in N-H...O=C hydrogen bonds, with formation of one C 17 ring structure, one α-turn (C 13 ), one γ-turn (C 7 ), and two β-turns (C 10 , one of type III and one of type I)
- Published
- 1992