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A detailed study of a room-temperature asymmetric Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes reports the series of 19 enol ethers bearing chiral auxiliaries with many providing highly diastereoselective reactions, largely the result of an exquisitely organized (4+2) cycloaddition transition site. Three readily accessible and unexplored auxiliaries rationally emerged from the studies and provide remarkable selectivities that promise to be useful in systems.

Synthesis process is described for a short and highly efficient manufacturing process of coenzyme Q10 (CoQ10). Synthetic CoQ10 was identical to authentic material in all respects and the typical impurities were completely averted during the synthetic process.