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Start Over Author "Parker, Anna" Journal journal of the american chemical society
4 results on '"Parker, Anna"'

1. Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging

Author

Gierse, Martin, primary, Nagel, Luca, additional, Keim, Michael, additional, Lucas, Sebastian, additional, Speidel, Tobias, additional, Lobmeyer, Tobias, additional, Winter, Gordon, additional, Josten, Felix, additional, Karaali, Senay, additional, Fellermann, Maximilian, additional, Scheuer, Jochen, additional, Müller, Christoph, additional, van Heijster, Frits, additional, Skinner, Jason, additional, Löffler, Jessica, additional, Parker, Anna, additional, Handwerker, Jonas, additional, Marshall, Alastair, additional, Salhov, Alon, additional, El-Kassem, Bilal, additional, Vassiliou, Christophoros, additional, Blanchard, John W., additional, Picazo-Frutos, Román, additional, Eills, James, additional, Barth, Holger, additional, Jelezko, Fedor, additional, Rasche, Volker, additional, Schilling, Franz, additional, Schwartz, Ilai, additional, and Knecht, Stephan, additional

Published
2023
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2. Hyperpolarized Solution-State NMR Spectroscopy with Optically Polarized Crystals

Author

Eichhorn, Tim R., primary, Parker, Anna J., additional, Josten, Felix, additional, Müller, Christoph, additional, Scheuer, Jochen, additional, Steiner, Jakob M., additional, Gierse, Martin, additional, Handwerker, Jonas, additional, Keim, Michael, additional, Lucas, Sebastian, additional, Qureshi, Mohammad Usman, additional, Marshall, Alastair, additional, Salhov, Alon, additional, Quan, Yifan, additional, Binder, Jan, additional, Jahnke, Kay D., additional, Neumann, Philipp, additional, Knecht, Stephan, additional, Blanchard, John W., additional, Plenio, Martin B., additional, Jelezko, Fedor, additional, Emsley, Lyndon, additional, Vassiliou, Christophoros C., additional, Hautle, Patrick, additional, and Schwartz, Ilai, additional

Published
2022
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3. Parahydrogen-Polarized Fumarate for Preclinical in VivoMetabolic Magnetic Resonance Imaging

Author

Gierse, Martin, Nagel, Luca, Keim, Michael, Lucas, Sebastian, Speidel, Tobias, Lobmeyer, Tobias, Winter, Gordon, Josten, Felix, Karaali, Senay, Fellermann, Maximilian, Scheuer, Jochen, Müller, Christoph, van Heijster, Frits, Skinner, Jason, Löffler, Jessica, Parker, Anna, Handwerker, Jonas, Marshall, Alastair, Salhov, Alon, El-Kassem, Bilal, Vassiliou, Christophoros, Blanchard, John W., Picazo-Frutos, Román, Eills, James, Barth, Holger, Jelezko, Fedor, Rasche, Volker, Schilling, Franz, Schwartz, Ilai, and Knecht, Stephan

Abstract

We present a versatile method for the preparation of hyperpolarized [1-13C]fumarate as a contrast agent for preclinical in vivoMRI, using parahydrogen-induced polarization (PHIP). To benchmark this process, we compared a prototype PHIP polarizer to a state-of-the-art dissolution dynamic nuclear polarization (d-DNP) system. We found comparable polarization, volume, and concentration levels of the prepared solutions, while the preparation effort is significantly lower for the PHIP process, which can provide a preclinical dose every 10 min, opposed to around 90 min for d-DNP systems. With our approach, a 100 mM [1-13C]-fumarate solution of volumes up to 3 mL with 13–20% 13C-hyperpolarization after purification can be produced. The purified solution has a physiological pH, while the catalyst, the reaction side products, and the precursor material concentrations are reduced to nontoxic levels, as confirmed in a panel of cytotoxicity studies. The in vivousage of the hyperpolarized fumarate as a perfusion agent in healthy mice and the metabolic conversion of fumarate to malate in tumor-bearing mice developing regions with necrotic cell death is demonstrated. Furthermore, we present a one-step synthesis to produce the 13C-labeled precursor for the hydrogenation reaction with high yield, starting from 13CO2as a cost-effective source for 13C-labeled compounds.

Published
2023
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