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Start Over Author "Nicholson, Lawrence" Journal journal of the american chemical society
1 results on '"Nicholson, Lawrence"'

1. An enzyme library approach to biocatalysis: Development of nitrilases for enantioselective production of carboxylic acid derivatives

Author

DeSantis, Grace, Hanson, Sarah R., Robertson, Dan E., Zhu, Zuolin, Farwall, Bob, Burk, Mark J., Greenberg, William E., Nicholson, Lawrence W., Wong, Kelvin, Rand, Cynthia L., Chaplin, Jenny, and Weiner, David P.

Subjects
Catalysis -- Methods, Carboxylic acids -- Chemical properties, Chemistry
Abstract

The discovery of a large and diverse set of nitrilases and the utility of this nitrilase library for identifying enzymes that catalyze efficient enantioselective production of valuable hydroxy carboxylic acid derivatives is reported. It is revealed that nitrilases that furnish mandelic and aryllactic acid derivatives as well as either enatiomer of 4-cyano-3-hydroxybutyric acid in high yield and enantiomeric excess.

Published
2002

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