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Your search keyword '"Muttenthaler, Markus"' showing total 3 results
Start Over Author "Muttenthaler, Markus" Journal journal of the american chemical society
3 results on '"Muttenthaler, Markus"'

1. Solving the [alpha]-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists

Author

Muttenthaler, Markus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan. T., Peng T. Choy, Daly, Norelle L., Shu-Hong Hu, Armishaw, Christopher J., Ching-I. A. Wang, Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J., and Alewood, Paul F.

Subjects
Cysteine -- Chemical properties, Nicotinic receptors -- Structure, Nicotinic receptors -- Chemical properties, Protein folding -- Analysis, Xenopus -- Physiological aspects, Chemistry
Abstract

The application of selenocysteine in a supported phase method to direct native folding and produce [alpha]-conotoxins efficiently with improved biophysical properties is reported. The results obtained provide insight into the development of more stable and potent nicotinic antagonists suitable for new drug therapies, and highlight the application of selenocysteine technology more broadly to disulfide-bonded peptides and proteins.

Published
2010

3. Solving the α-Conotoxin Folding Problem: Efficient Selenium-Directed On-Resin Generation of More Potent and Stable Nicotinic Acetylcholine Receptor Antagonists

Author

Muttenthaler, Markus, primary, Nevin, Simon T., additional, Grishin, Anton A., additional, Ngo, Shyuan. T., additional, Choy, Peng T., additional, Daly, Norelle L., additional, Hu, Shu-Hong, additional, Armishaw, Christopher J., additional, Wang, Ching-I. A., additional, Lewis, Richard J., additional, Martin, Jennifer L., additional, Noakes, Peter G., additional, Craik, David J., additional, Adams, David J., additional, and Alewood, Paul F., additional

Published
2010
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